Infectious diseases often result in increased morbidity and mortality, as well as during the Corona Virus pandemic. Children and adolescents are one of the groups at risk for transmission. Transmission of covid-19 in children and adolescents is not too much. This is due to factors related to the behavior of adolescent to prevent the transmission of covid-19. This study aims to analyze factors related to the role and behavior of adolescents in preventing the transmission of covid-19 in terms of predisposing, enabling, reinforcing and environmental factors. The research method is observational with a cross sectional design. The population is adolescents aged 10 -21 years in Bareng and Tanjungrejo Sub-Districts, Malang City with a total of 551 people. Samples were taken by simple random technique of 139 respondents. Data analysis used linear regression test. Results: role strengthening factors include predisposing, enabling, reinforcing and the environment significantly influence adolescent behavior in preventing transmission of Covid-19 with a value (P-value) < α = 0.05. This shows that all the factors tested are related to the behavior of adolescents to comply in implementing health protocols. The role and behavior of adolescents in preventing infectious diseases needs to be continuously strengthened by various relevant factors so that they can actively participate in preventing its transmission and spread.