The influence of Ringer's lactate or HES 130/0.4 administration on the integrity of the small intestinal mucosa in a pig hemorrhagic shock model under general anesthesia

Ortiz, A.; Vala, Helena; Venâncio, Carlos; Mesquita, João R.; Silva, Aura; Orden, José Manuel Gonzalo; Ferreira, D.

doi:10.1111/vec.12560

Cited by 4 publications

(8 citation statements)

References 35 publications

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“…There are many reports on the effects of HES130 administration in patients with massive hemorrhages; HES130 has been shown to shorten the recovery time from shock [12], improve peripheral circulation and vascular permeability, improve the symptoms of edema in small intestinal mucosa [30], and decrease the concentrations of GCX fragmentation products (syndecan-1, heparanase, and hyaluronic acid) [31]. In addition, in a clinical study of HES130 treatment in trauma patients, an improvement of base excess [32] and lactic acid levels was reported.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of hydroxyethyl starch solution on the glycocalyx layer in an acute hemorrhage mouse model

et al. 2019

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Purpose Fluid therapy focused on glycocalyx (GCX) protection in hemorrhagic shock is a current focus of research. Hydroxyethyl starch (HES) solution is commonly used for fluid resuscitation; however, its effects on the GCX remain unclear. The primary aim of this study was to explore the protective effect of HES130 in maintaining GCX thickness and reducing plasma syndecan-1 expression. Methods An acute hemorrhage murine model with the dorsal skin chambers was used to measure GCX thickness and to evaluate vascular permeability. Groups of mice were treated with normal saline (NS), albumin (NS-A), HES130 (NS-V), or no exsanguination or infusion (C). We measured syndecan-1 plasma concentrations, performed blood gas analysis, and analyzed the 7-day cumulative mortality. Results GCX thickness in NS mice was significantly reduced compared to that in group C, but no other groups showed a difference compared to group C. The plasma concentration of syndecan-1 was significantly higher in NS mice than in group C. There were no significant differences in the fluorescence intensity of dextran in the interstitial space. HES70 leakage was suppressed in NS-V mice compared to those in other groups. HES70 was localized to the inner vessel wall in C, NS, and NS-A mice, but not in group NS-V. Blood gas analysis indicated that pH and lactate showed the greatest improvements in NS-V mice. The 7-day cumulative mortality rate was the highest in group NS. Conclusion Resuscitation with HES130 protected the GCX and suppressed vascular permeability of HES70 during early stages of acute massive hemorrhage.

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Section: Discussionmentioning

confidence: 99%

The protective effect of hydroxyethyl starch solution on the glycocalyx layer in an acute hemorrhage mouse model

et al. 2019

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“…All pigs in this study were also used in the Ortiz et al's study [ 28 ]. Additionally, twelve randomly selected pigs from this group were also included in two other studies by the same authors [ 32 33 ] in which pigs received an intravenous 5 µg/kg remifentanil bolus before the bleeding period had started.…”

Section: Methodsmentioning

confidence: 99%

“…The material and methods related to experimental procedures of the present manuscript (anesthesia, monitoring procedures, study periods, and data collection), and the data comparing all groups (demographic, hemodynamic, body temperature, duration of the study periods, and gas analysis) are described in detail in a report by Ortiz et al [ 28 ] and reports by Silva et al [ 32 33 ].…”

Section: Methodsmentioning

confidence: 99%

“…In brief, we summarize the methodology relevant to the present study, as originally described by Ortiz et al [ 28 ]. Pigs were fasted overnight but they were allowed free access to water.…”

Section: Methodsmentioning

confidence: 99%

“…The 25 mL/kg RL solution dose used was the minimum dose necessary to obtain a similar hemodynamic response to that of HES 130/0.4 administration during volume replacement (hemodynamic response of Group 1 and Group 2 is reported in detail in Ortiz et al's study [ 28 ]), as determined during pretrial testing in pigs. After the end of volume replacement, pigs from Groups 1 and 2 were maintained under general anesthesia for an additional hour.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

et al. 2018

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This work aimed to evaluate the effects on renal tissue integrity after hydroxyethyl starch (HES) 130/0.4 and Ringer's lactate (RL) administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. After bleeding, Group 1 (n = 11) received RL solution (25 mL/kg) and Group 2 (n = 11) received HES 130/0.4 solution (20 mL/kg). Additionally, Group 3 (n = 6) was not submitted to bleeding or volume replacement. Pigs were euthanized and kidneys were processed for histopathological and immunohistochemical analyses. Minimal to moderate glomerular, tubular, and interstitial changes, as well as papillary necrosis, were observed in all experimental groups. Pre-apoptosis and apoptosis indicators were higher in pigs that received HES 130/0.4, indicating a higher renal insult. Both HES 130/0.4 and RL administration may cause renal injury, although renal injury may be more significant in pigs receiving HES 13/0.4. Results also suggest that total intravenous anesthesia with propofol and remifentanil may cause renal injury, and this effect can be dose related.

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Characteristics of New Oxygen-Carrying Plasma and Its Application Prospects in the Treatment of Severe Acute Pancreatitis

et al. 2023

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Oxygen-carrying plasma, a new type of colloid substitute, is composed of hydroxyethyl starch and acellular hemoglobin-based oxygen carriers. It can supplement colloidal osmotic pressure and rapidly improve the body's oxygen supply. The resuscitation effect of the new oxygen-carrying plasma in animal shock models is better than that of hydroxyethyl starch or hemoglobin-based oxygen carriers alone. It can reduce the histopathological damage and mortality associated with severe acute pancreatitis, and it is expected to become an interesting treatment method for severe acute pancreatitis. This article reviews the characteristics of the new oxygen-carrying plasma, its role in fluid resuscitation, and its application prospects in the treatment of severe acute pancreatitis.

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The influence of Ringer's lactate or HES 130/0.4 administration on the integrity of the small intestinal mucosa in a pig hemorrhagic shock model under general anesthesia

Cited by 4 publications

References 35 publications

The protective effect of hydroxyethyl starch solution on the glycocalyx layer in an acute hemorrhage mouse model

The protective effect of hydroxyethyl starch solution on the glycocalyx layer in an acute hemorrhage mouse model

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

Characteristics of New Oxygen-Carrying Plasma and Its Application Prospects in the Treatment of Severe Acute Pancreatitis

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