The influence of small oligosaccharides on the immune system

Bland, Elliot James; Keshavarz, Tajalli; Bucke, C.

doi:10.1016/j.carres.2004.05.009

Cited by 55 publications

(42 citation statements)

References 24 publications

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“…The immunostimulatory effects of prebiotics have been widely documented in recent years (Bland et al 2004. Hoyles and Vulevic 2008, Gu et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The ability of prebiotics to stimulate phagocytosis has been well documented (Tzianabos 2000, Bland et al 2004), therefore, a phagocytosis assay should be the first test to investigate the immunological characteristics of Biolex-MB40. In this experiment, a significant increase in the phagocytic activity, expressed as the percentage of phagocytes, and a significant increase in the average number of bacteria eliminated by one phagocyte, expressed as average fluorescence intensity of monocytes and granulocytes, were observed in the experimental animals administered Biolex-MB40 in comparison with the control lambs.…”

Section: Discussionmentioning

confidence: 99%

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The effect of Biolex-MB40 on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in lambs

Wójcik¹

2014

Polish Journal of Veterinary Sciences

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The objective of this study was to determine the effect of Biolex-MB40 on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in lambs. The experimental material comprised 32 lambs aged 30 ± 3 days, divided into two equal groups: control and experimental. Experimental group animals were fed a diet supplemented with the Biolex-MB40 (Saccharomyces cerevisiae) in the amount of 3 g/kg of the concentrate. At the beginning of the experiment (day 0) and on experimental days 15, 30 and 60, blood was sampled from the jugular vein to determine and compare the phagocytic activity (PHAGOTEST) and oxidative metabolism (BURSTTEST) of peripheral blood granulocytes and monocytes by flow cytometry. Based on the results of an analysis of granulocyte and monocyte phagocytic activity, statistically higher levels of phagocytic activity were observed in the group of lambs administered Biolex-MB40 than in the control animals, expressed in terms of the percentage of phagocytic cells as well as mean fluorescence intensity. Biolex-MB40 also had a positive effect on the oxidative metabolism of both granulocytes and monocytes after stimulation with Escherichia coli bacteria and with PMA (4-phorbol-12-β-myristate-13-acetate), expressed in terms of the percentage of oxidative metabolism as well as mean fluorescence intensity.

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“…The immunostimulatory effects of prebiotics have been widely documented in recent years (Bland et al 2004. Hoyles and Vulevic 2008, Gu et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of Biolex-MB40 on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in lambs

Wójcik¹

2014

Polish Journal of Veterinary Sciences

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“…Em anos mais recentes verificou-se que muitos oligossacarídeos, principalmente aqueles com seis ou mais unidades monossacarídicas, conservam ou até mesmo potencializam as propriedades biológicas apresentadas por seus polissacarídeos. Uma possível explicação para essa constatação é a maior solubilidade dos oligossacarídeos, uma menor massa molecular e a manutenção da conformação quando comparados às suas moléculas nativas (BLAND; KESHAVARZ;BUCKE, 2004).…”

Section: Obtenção De Oligossacarídeos Por Métodos Físicos E Químicosunclassified

“…A laminariheptose tem sido descrita por possuir atividade biológica distinta da laminarihexose devido à conformação espacial que a presença de uma molécula de glucose a mais confere ao oligossacarídeo, o que parece favorecer a sua interação com as células imunes humanas (LOWE et al, 2001;BLAND;KESHAVARZ, T.;BUCKE, 2004).…”

Section: Atividades Biológicas Dos Oligossacarídeosunclassified

Produção, propriedades e aplicações de oligossacarídeos

et al. 2011

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ResumoOs oligossacarídeos participam da constituição da fibra alimentar e são principalmente utilizados como prebióticos. Esta revisão apresenta as vias de obtenção destes açúcares, os quais podem ser produzidos por síntese (química ou enzimática) ou da despolimerização de polissacarídeos (física, química ou enzimática), como descrito na presente revisão. Os oligossacarídeos vêm sendo utilizados comercialmente como ingredientes de cosméticos, medicamentos, produtos agrícolas e principalmente na indústria alimentícia. O potencial de aplicações dos oligossacarídeos nessas áreas nas mais diversas áreas tais como alimentos, rações animais, fármacos e cosméticos tem contribuído para o aumento das investigações científicas. O uso de oligossacarídeos como agentes imunomoduladores e modificadores de respostas biológicas foi recentemente descrito, assim como seus efeitos como compostos antiinflamatórios e hipocolesterolêmicos. Uma visão geral sobre as diversas funções nutracêuticas e biológicas destes oligômeros de carboidratos visando benefícios para a saúde humana também foi reportada. Palavras-chave: Oligossacarídeos. Fibras da dieta. Saúde humana. AbstractOligosaccharides participate in the formation of dietary fiber and are mainly used as prebiotic agents. This review presents ways of obtaining these sugars, which can be produced by synthesis (chemical or enzymatic), or through depolymerization of polysaccharides (physical, chemical or enzymatic). Oligosaccharides have also been used commercially as an ingredient in cosmetics, pharmaceuticals, agricultural products and especially in the food industry because of their physical properties. The potential applications of oligosaccharides in several areas such as food, animal feed, pharmaceuticals and cosmetics have contributed to the increase in scientific research on these carbohydrates. The use of oligosaccharides as immuno-modulatory agents and biological response modifiers has been recently described, and their effects as anti-inflammatory and in reducing cholesterol. An overview of the various nutraceutical and biological functions of these carbohydrates in order to benefit human health is also reported.

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“…The control of both food borne pathogens and pathogens causing mortality and growth suppression in production animals is especially important for economic livestock production. For the incidence of Salmonella, strict limits have been proposed by EU regulatory authorities [2,3].…”

Section: Introductionmentioning

confidence: 99%

Morphological Characterization of Pichia guilliermondii and Saccharomyces cerevisiae Yeast and their Effects on Adherence of Intestinal Pathogens on Piglet and Chicken Epithelium In-vitro

Peisker¹,

Stensrud²,

Apajalahti³

et al. 2017

J Anim Res Nutr

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Intestinal pathogen binding effects are related to mannanoligocaccharides that occur in several micro-organism species e.g. fungi and yeasts. Binding varies between species depending on their size, structure and cell wall properties. The purpose of the study was to elucidate differences in adherence potential of commercially used yeast cells and possibly determine causative elements for the observed differences. Electron microscopy and surface hydrophobicity measurements reveal that Pichia guilliermondii yeast possesses distinguished traits compared to Saccharomyces cerevisiae that may account for observed differences in pathogen binding efficiency. Pichia guilliermondii significantly inhibited adherence of pathogenic strains of Escherichia coli and Salmonella enterica in small intestinal epithelium of swine and broiler chicken. Treatment of Pichia yeast with digestive fluids significantly increased this effect. In-vivo, gastric activation occurs naturally as verified by broiler assays with P. guilliermondii. P. guilliermondii and S. cerevisiae retained their inhibitory effects on pathogenic E. coli adherence after passing through the upper digestive tract. Jejunal digesta recovered from birds treated with P. guilliermondii showed higher inhibitory effect than digesta from birds treated with the S. cerevisiae yeast. The inhibitory effect was still detectable in ileal digesta. Intact, non-gastric treated P. guilliermondii was as effective as the gastric pre-treated yeast, suggesting that digestive enzymes of broiler chicken were capable of activating yeast cells in-situ.

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The influence of small oligosaccharides on the immune system

Cited by 55 publications

References 24 publications

The effect of Biolex-MB40 on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in lambs

The effect of Biolex-MB40 on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in lambs

Produção, propriedades e aplicações de oligossacarídeos

Morphological Characterization of Pichia guilliermondii and Saccharomyces cerevisiae Yeast and their Effects on Adherence of Intestinal Pathogens on Piglet and Chicken Epithelium In-vitro

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