The influence of standardized dry ivy leaf extract on the proportion of nasal secretion after post-septoplasty nasal packing removal

Savovic, Slobodan; Kusturica, Milica Paut; Kljajić, Vladimir; Cupic, Maja Buljcik; Jovančević, Ljiljana; Pavlović, Vedrana; Rašković, Aleksandar

doi:10.1016/j.bjorl.2018.05.005

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…Several supplements administered to septoplasty patients demonstrated beneficial effects. Postoperative septoplasty patients treated with topical dry ivy leaf extract demonstrated significantly less nasal excretion than the control group 13 . In another study, patients were splinted postoperatively with Nazalzem ointment, consisting of vitamin A and dexpanthenol.…”

Section: Resultsmentioning

confidence: 97%

“…Postoperative septoplasty patients treated with topical dry ivy leaf extract demonstrated significantly less nasal excretion than the control group. 13 In another study, patients were splinted postoperatively with Nazalzem ointment, consisting of vitamin A and dexpanthenol. This combination reduced nasal crusting and congestion.…”

Section: Beneficial Healing Effectsmentioning

confidence: 99%

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Healing Adjuncts in Craniofacial Surgery: Review of Dietary Vitamins and Supplements

Spielman

Epstein

Jabori

et al. 2020

Journal of Craniofacial Surgery

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Background: In the United States, the use of herbal supplements on a regular basis ranges from 32% to 97%. Prevalence of supplement use is particularly elevated after facial surgery. It has been reported as high as 50%. Unfortunately, there is a paucity of literature on the dietary use of supplements. They are not regulated by the FDA. Often, they are not reported by patients. This study examines the role of dietary supplements as adjuncts to healing in craniofacial and facial aesthetic surgeries. Methods: A comprehensive literature review was conducted using MEDLINE, PubMed, and EMBASE. Databases were screened for papers describing the use of supplements in craniofacial procedures in adult patients using relevant search terms. Data on criteria, outcomes, and patient satisfaction were collected. Results: A total of 19 articles were selected from the 806 identified. Fifteen different supplements or combinations of supplements have been studied for use in facial surgeries. Of these 15 supplements, the following demonstrated potential healing benefits: dry ivy leaf extract, Nazalzem ointment (vitamin A and dexpanthenol), combination nasal sprays (phospholipids, fatty acids, vitamin A, and vitamin E), Saireito pills, topical olive oil, yunnan baiyao, melilotus extract, arnica, and combination arnica and ledum. Arnica is the most commonly studied supplement in a variety of facial operations. Conclusions: There is ample evidence to support a role for the use of certain dietary supplements to optimize wound healing in craniofacial and facial aesthetic surgery. Controlled diet and use of appropriate supplements may have a synergistic beneficial effect on wound healing following craniofacial surgery. However, there is a need for additional reporting to allow for the creation of stronger guidelines and increased patient screening, reporting, and compliance.

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Section: Resultsmentioning

confidence: 97%

Section: Beneficial Healing Effectsmentioning

confidence: 99%

Healing Adjuncts in Craniofacial Surgery: Review of Dietary Vitamins and Supplements

Spielman

Epstein

Jabori

et al. 2020

Journal of Craniofacial Surgery

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“…According to the study performed by Savović et al, 14 sample size calculation was based on expectation that therapy leads to transition from severe to moderate degree in endoscopically evaluated mucosal edema. The sufficient total sample sizes of 25 participants in each group provided at least 80% study power, at 0.05 significance level, to reveal an average difference in mucosal edema score of 1 between two treatment options.…”

Section: Methodsmentioning

confidence: 99%

Herbal Drug EPs 7630 versus Amoxicillin in Patients with Uncomplicated Acute Bacterial Rhinosinusitis: A Randomized, Open-Label Study

Perić

Gaćeša²,

Barać

et al. 2020

Ann Otol Rhinol Laryngol

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Objective: Previous investigations suggest the use of extract from the root of Pelargonium sidoides (EPs 7630) for the therapy of uncomplicated acute upper airway inflammations, due to its strong antimicrobial and immunomodulatory effect. We aimed to compare clinical efficacy, safety and bactericidal effect of EPs 7630 and amoxicillin monotherapy in treatment of patients with mild to moderate acute bacterial rhinosinusitis (ABRS). Methods: Fifty ABRS patients were divided into two groups by randomization. Group 1 (n = 25) received EPs 7630 tablets, 3 × 20 mg/day per os for 10 days. Group 2 (n = 25) received amoxicillin tablets 3 × 500 mg/day per os, for 10 days. We assessed total symptom score (TSS), individual symptom scores for each symptom (nasal obstruction, rhinorrhea, postnasal drip, facial pain/pressure, loss of the sense of smell), endoscopic findings, including total endoscopic score (TES) and individual endoscopic signs (mucosal edema, mucopurulent secretion), before and after treatment. Samples of discharge taken from the middle meatus of all patients were cultivated for bacteria before and after therapy. Results: Higher absolute improvement after treatment was found for TSS, nasal obstruction, facial pain/pressure, impaired sense of smell, TES, mucosal edema and mucopurulent secretion in EPs 7630 group compared to amoxicillin group ( P < .001 for all parameters). However, there were no differences in absolute improvement of rhinorrhea score and postnasal drip score between groups ( P = .248; P = .679, respectively). Fewer types of bacteria grew on culture from middle meatal samples in EPs 7630 group compared to amoxicillin group. There were no reported adverse events from patients from either group. Conclusion: Our results demonstrated better clinical and antimicrobial efficacy of EPs 7630 than amoxicillin. EPs 7630 was shown as a potent agent and good alternative to antibiotic treatment of uncomplicated ABRS.

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“…A avaliação subjetiva de secreção nasal do grupo II se mostrou significativamente maior que a do grupo I, bem como valores estatisticamente relevantes de secreção foram encontrados também em relação aos pacientes tratados com xarope de H. helix. Também se observou que o grupo I não mostrou sinais de infecção local, diferentemente do controle, cujo maior volume de secreção nasal criou um ambiente propício para crescimento bacteriano (Savović et al, 2019). Esses resultados, além de confirmarem o potencial secretolítico da espécie já afirmado por autores supracitados (Song et al, 2015;Schaefer et al, 2020), também demonstram o forte potencial do uso do xarope na prática clínico-cirúrgica.…”

Section: Atividade Expectorante E Antitussígenaunclassified

“…A úlcera é uma das doenças mais comuns que atinge a população mundial, a qual é causada por um desequilíbrio entre os fatores endógenos de proteção da mucosa gástrica e os fatores agressivos (Savović et al, 2019). Com isso, devido às reações adversas, interações medicamentosas, incidência de recaídas e resistência advindas do tratamento para esta doença, o uso de medicamentos com atividade antiulcerosa, torna-se uma alternativa terapêutica (Mulkijanyan et al, 2013).…”

Section: Atividade Preventiva De úLcerasunclassified

Hedera helix L.: uma revisão dos recentes estudos de suas propriedades farmacológicas

Menezes,

Magalhães,

Andrade

et al. 2023

Revista JRG

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Objetivo: Buscar na literatura quais evidências científicas recentes corroboram para as propriedades farmacológicas da H. helix L. Método: Trata-se de uma revisão integrativa da literatura. Foram realizadas buscas nas bases de dados eletrônicas: Biblioteca Virtual em Saúde (BVS), EMBASE e SciVerse Scopus. O intervalo temporal escolhido abrangeu de 2013 a 2023. Resultados: Um total de 40 artigos foram encontrados na base de dados BVS, 27 na Scopus e 8 na Embase. Diante dos critérios de inclusão e exclusão, que responderam à questão norteadora, foram selecionados 13 artigos para análise integral. O uso do extrato da H. helix, como medicamento fitoterápico, é reconhecido pela Agência Nacional de Vigilância Sanitária (ANVISA) pela RE Nº 4.287, de 23 de setembro de 2011, e este uso terapêutico como agente expectorante e antitussígeno é validado cientificamente por publicações científicas. Dentre as atividades farmacológicas comprovadas, destacam-se: expectorante, antitussígena, anticancerígena, anti-inflamatória, antioxidante, antiangiogênicas, neuroprotetora e antiúlcera preventivo. Considerações finais: Diante da importância terapêutica da H. helix como uma planta medicinal promissora com ampla gama de atividades farmacológicas, podendo ser utilizada em diversas aplicações médicas devido à sua eficácia e segurança.

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The influence of standardized dry ivy leaf extract on the proportion of nasal secretion after post-septoplasty nasal packing removal

Abstract: The use of the standardized dry ivy leaf extract after nasal packing removal significantly lowers the proportion of nasal secretion.

Cited by 4 publications

References 23 publications

Healing Adjuncts in Craniofacial Surgery: Review of Dietary Vitamins and Supplements

Healing Adjuncts in Craniofacial Surgery: Review of Dietary Vitamins and Supplements

Herbal Drug EPs 7630 versus Amoxicillin in Patients with Uncomplicated Acute Bacterial Rhinosinusitis: A Randomized, Open-Label Study

Hedera helix L.: uma revisão dos recentes estudos de suas propriedades farmacológicas

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