The Influence of Supplementation of Anthocyanins on Obesity-Associated Comorbidities: A Concise Review

Abstract

Anthocyanins are water-soluble plant pigments, and based on their chemical structure (nature, position, and the number of sugar moieties attached; the number of hydroxyl groups; acylation of sugars with acids) about 635 different anthocyanins have been identified and reported from plants. Cyanidin, peonidin, pelargonidin, petunidin, and malvidin are the commonly found anthocyanidins (aglycon forms of anthocyanins) in edible plants out of almost 25 anthocyanidins that are identified (based on the position of methoxyl and hydroxyl groups in the rings) in nature. Anthocyanins are known for numerous health benefits including anti-diabetes, anti-obesity, anti-inflammatory bowel disease, anti-cancer, etc. Obesity can be defined as excessive or abnormal adipose tissue and body mass, which increases the risk of developing chronic diseases such as diabetes, cardiovascular diseases, cancers, etc. The manuscript summarizes the recent updates in the effects of anthocyanins supplementation on the health status of obese subjects, and briefly the results of in vitro and in vivo studies. Several studies confirmed that the consumption of anthocyanins-rich food improved obesity-associated dysbiosis in gut microbiota and inflammation in adipose tissue. Anthocyanin consumption prevents obesity in healthy subjects, and aids in maintaining or reducing the body weight of obese subjects, also improving the metabolism and energy balance. Though preclinical studies proved the beneficial effects of anthocyanins such as the fact that daily intake of anthocyanin rich fruits and vegetables might aid weight maintenance in every healthy individual, Juҫara pulp might control the inflammatory status of obesity, Queen garnet plum juice reduced the blood pressure and risk factors associated with metabolic disorders, and highbush organic blueberries improved the metabolism of obese individuals, we don’t have an established treatment procedure to prevent or manage the over-weight condition and its comorbidities. Thus, further studies on the optimum dose, duration, and mode of supplementation of anthocyanins are required to develop an anthocyanins-based clinical procedure.

ROS Modulating Effects of Lingonberry (Vaccinium vitis-idaea L.) Polyphenols on Obese Adipocyte Hypertrophy and Vascular Endothelial Dysfunction

“…Several in vitro and in vivo studies confirmed that ACN-rich food consumption prevents obesity-related consequences such as diabetes, inflammation and oxidative stress. ACN supplementation favorably alters genes involved in glucose, FA and lipid metabolism, immune and inflammatory system, antioxidant defense, and the antiangiogenic system [ 48 ].…”

Lesser Investigated Natural Ingredients for the Management of Obesity

“…Anthocyanins, the pigmented flavonoids, have anti-inflammatory, anti-diabetic and anti-obesity activities. In animals, anthocyanin supplementation reduced body weight gain, visceral fat and lipid levels, and alleviated leptin resistance [ 149 ]. Purified cyanidin-3-glucoside was found to induce thermogenesis by increasing mitochondrial UCP1 expression and activating AMPK phosphorylation [ 149 ].…”

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

“…Vital et al found that cyanidin and delphinidin glucosides are potent inductors of insulin secretion [ 9 ]. It was observed that the consumption of anthocyanidin-rich extracts prevents obesity in healthy subjects, and helps to reduce the body weight of obese subjects [ 10 ]. Silveira et al report that the daily intake of red orange juice (cyanidin glucosides as major active factors) [ 21 ] leads to an increase in serum antioxidant activity and reduction in the levels of C-reactive protein as well as total- and low-density lipoprotein cholesterol [ 22 ].…”