The Influence of the Gonads on the Functional Development of the Hypothalamo-Hypophysial System of the Male Rat

Marić, D.; Tadić, R; Miline, R.

doi:10.1159/000122297

Cited by 6 publications

(3 citation statements)

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“…There are numerous studies suggesting that it is initiated during the last week of gestation and is completed a few days after birth (1)(2)(3)(23)(24)(25)(26)(27). However, there are only a few reports dealing with levels of circulating testosterone in the two sexes throughout this period.…”

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confidence: 99%

Plasma Testosterone and Progesterone Titers of Pregnant Rats, Their Male and Female Fetuses, and Neonatal Offspring*

1980

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Testosterone and progesterone titers were determined by RIA in the plasma of pregnant rats and their male and female fetuses from day 17 of gestation through the day of birth and in male and female neonates on days 3 and 5 post partum. Males had significantly higher mean testosterone levels than females from day 18 of gestation through day 5 post partum. Sex differences in plasma testosterone concentrations were greatest in the fetuses on days 18 and 19 of gestation when testosterone levels peaked in the males. Instances in which female fetuses had testosterone titers equal to or greater than their male littermates were found on every day of gestation except day 18. Mean testosterone concentrations in plasma of female fetuses were high throughout gestation (greater than 1000 pcg/ml). Testosterone concentrations decreased in both sexes after birth. Differences between the sexes remained significant, and although there was an overlap in the values for males and females, testosterone concentrations in females exceeded those of their male littermates in only one out of nine pairs of samples on day 5 and in none of seven pairs on day 3 post partum. There were no significant differences in progesterone levels in plasma of males and females, either pre- or postnatally. Progesterone titers changed as a function of days post conception in both the fetuses and their mothers. In the fetuses, progesterone levels declined progressively from day 18 post conception through the day of birth, while in the mother they rose from days 18 to 19 then declined between days 20 and 21 of pregnancy. Fetuses had lower progesterone titers than their mothers. From these data, we conclude that day 18 and possibly day 19 post conception represent a critical period during which the central nervous system of the male is primed by high levels of testosterone. Thereafter, the process of masculinization is completed by exposure to testosterone levels that are relatively low and need not be consistently higher than those of female littermates.

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Plasma Testosterone and Progesterone Titers of Pregnant Rats, Their Male and Female Fetuses, and Neonatal Offspring*

1980

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“…Relying on years of high-quality research in the field of animal physiology, specifically in reproductive endocrinology e.g. [1][2][3][4][5][6][7][8][9], the activities of LECOTOX researchers were (and still are) focused on toxic impact of persistent organic pollutants (POPs) on biota with special emphasis on specific sublethal types of toxicity -endocrine disruption, reproductive toxicity, and "dioxin-like" toxicity [10][11][12][13][14][15][16]. Bio analyses based on molecular and cellular biomarkers of effects, such as cytochrome P450 (CYP) enzyme induction and parameters and markers of oxidative stress and early intoxication have been applied in assessment of freshwater ecosystems e.g.…”

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confidence: 99%

“…Four outstanding EU institutions have supported the project by offering their expertise and highquality trainings for LECOTOX young researchers: (1) …”

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confidence: 99%

REP-LECOTOX: an example of FP 6 INCO project to strengthen ecotoxicological research in WBC (Western Balkan countries)

et al. 2011

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FP6 (2007FP6 ( -2009) presented a crucial milestone for LECOTOX, both in terms of overall research performance and its visibility and presentation to international scientific community. The project enabled upgrading and renewal of S&T equipment, hiring new young researchers to reinforce human resources and it facilitated extensive networking -via workshops, exchange of scientific personnel and trainings of young scientists in some of the finest research institutions in the EU in the field of environmental research: Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany; School of Bioscience, University of Birmingham, UK and RECETOX, Masaryk University, Brno, Czech Republic. The project enabled LECOTOX, focusing mainly on two research topics, i.e. endocrine disruption/ reproductive toxicity, and identification and characterisation of aquatic toxicity, to form a functional competitive research team ready for combining transcriptomics with the established conventional toxicity tests and traditional function-based biomarkers. LECOTOX became well-equipped and experienced research group confident enough to join any FP or otherwise funded ecotoxicological research project and network.

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Sexual Behavior Differentiation

Ward

1985

Reproduction

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The Influence of the Gonads on the Functional Development of the Hypothalamo-Hypophysial System of the Male Rat

Cited by 6 publications

References 0 publications

Plasma Testosterone and Progesterone Titers of Pregnant Rats, Their Male and Female Fetuses, and Neonatal Offspring*

Plasma Testosterone and Progesterone Titers of Pregnant Rats, Their Male and Female Fetuses, and Neonatal Offspring*

REP-LECOTOX: an example of FP 6 INCO project to strengthen ecotoxicological research in WBC (Western Balkan countries)

Sexual Behavior Differentiation

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