The influence of the new hypoglycemic agent Limiglidol on the parameters of hemostasis in experimental diabetes mellitus

Abstract

Platelet aggregation was assessed by the method of G. Born modified as described by Z.A. Gabbasov. Blood viscosity was measured using an AKR-2 rotating-type viscometer - rheological blood analyzer at six shear rates (10 s-1, 20 s-1, 50 s-1, 100 s-1, 200 s-1, and 300 s-1) simulating different intensities of the blood flow through the vessels. The model of arterial thrombosis induced by electrical current was constructed based on the method of G. Guglielmi et al (1991). Gliclazide was used in the studies of Limiglidol antiaggregant and antithrombotic properties and pentoxifylline in the studies of the influence of Limiglidol on rheological blood properties. It was shown that Limiglidol inhibited platelet aggregation and prolonged the time of thrombus formation. It proved to be superior to gliclazide in terms of these activities and reduced blood viscosity to a higher degree than pentoxifylline.

Antidiabetogenic Features of Benzimidazoles

“…Diabenol reduced the aggregability and increased the erythrocyte deformability in normal conditions and, more profoundly, in experimental diabetes. Using fluorescent probes, it has been shown that diabenol was able to increase electronegativity and reduces the microviscosity of the red blood cells membrane, which results in the increase in their deformability [53][54][55][56].…”