“…A critical note has to be made on pooling data from separate studies. During the search, we found several studies which used inappropriate randomization techniques or did not claim to be randomized, and they were thus excluded (Dorr et al 1988, Becker et al 1991, Maloney and Schurman 1992, Hirsch et al 1994, Vinciguerra et al 1994, Cash et al 1996, Laskin 1996, Simmons et al 1996, Stiehl et al 1997, Ishii et al 1998, Pereira et al 1998, Udomkiat et al 2000, Cope et al 2002. In all of these studies, we cannot rule out selection bias, so the results should be interpreted with less certainty than the results from the meta-analysis and bestevidence synthesis.…”