The influence of the S19W SNP of the APOA5 gene on triglyceride levels in southern Brazil: Interactions with the APOE gene, sex and menopause status

Andrade, Fabiana Michelsen de; Maluf, Sharbel Weidner; Schuch, Jaqueline Bohrer; Voigt, Francine; Barros, Alessandra C.; Lucatelli, Juliana F.; Hutz, Mara H.

doi:10.1016/j.numecd.2009.12.013

Cited by 24 publications

(27 citation statements)

References 31 publications

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“…In particular, a change to a potentially atherogenic profile is seen in women after menopause which can be corrected by hormone treatment Nerbrand et al, 2004). Genetic interactions have also focused on apolipoprotein E (APOE), a major determinant in lipoprotein metabolism and a risk factor for Alzheimer's disease, but rarely on other polymorphisms involved in dyslipidemia phenotype, such as APOA5 and cholesteryl ester transfer protein (CETP) promoting the exchange of triglyceride (TG) for cholesteryl ester in lipoprotein (De Andrade et al, 2011;Sanders et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Gender-specific associations between lipids and cognitive decline in the elderly

Ancelin

Ripoche

Dupuy

et al. 2014

European Neuropsychopharmacology

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The aim of this study was to examine the associations between serum lipid levels and cognitive function in a community-based sample of non-demented subjects aged 65 years and over.Participants were 2737 men and 4118 women from a population-based cohort recruited from three French cities. Visual memory, verbal fluency, psychomotor speed, and executive abilities were evaluated at baseline, and after 2, 4, and 7 years of follow-up. Lipid levels were evaluated at baseline. Multiadjusted Cox models stratified by gender were adjusted for sociodemographic and lifestyle characteristics, mental and physical health, and genetic vulnerability to dyslipidemia (apolipoprotein E and A, and cholesteryl ester transfer protein) and taking into account baseline vascular pathologies. In men, a hypercholesterolemic pattern in late-life (high total cholesterol (T-C), low HDL-C, high LDL-C levels) was associated with a 25 to 50% increased risk of decline over 7 years in psychomotor speed, executive abilities, and verbal fluency. Specific associations with low T-C and low LDL-C levels were also observed which may depend on genetic vulnerability to dyslipidemia (related to apolipoprotein A5 and cholesteryl exchange transfer protein). In contrast, in women, a 30% higher rate of decline was found in psychomotor speed with high HDL-C levels and in executive abilities with low levels of LDL-C and triglycerides, in interaction with hormonal treatment. For men and women, vascular pathologies only slightly outweighed the risk related to lipids. This suggests a complex gender-specific pattern of cognitive decline involving genetic vulnerability in men and hormonal status in women.

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Section: Introductionmentioning

confidence: 99%

Gender-specific associations between lipids and cognitive decline in the elderly

Ancelin

Ripoche

Dupuy

et al. 2014

European Neuropsychopharmacology

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“…APOA5, another apolipoprotein, has been reported to be an important regulator of TG levels (Hubacek et al, 2004). Polymorphisms in APOA1 and APOA5 genes have been associated with lipid alterations and CVD (Hubacek et al, 2004;de Andrade et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Short Communication Association of APOA1 and APOA5 polymorphisms and haplotypes with lipid parameters in a Brazilian elderly cohort

Furuya

Chen²,

Ota³

et al. 2013

Genet. Mol. Res.

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ABSTRACT.Apolipoproteins have an important role in lipid metabolism and transport. Polymorphisms in the APOA1/C3/A4/ A5 gene cluster have been associated with lipid alterations and cardiovascular diseases. We investigated APOA1 XmnI, APOA5 S19W, and APOA5 -1131T>C polymorphisms in 377 individuals from a cohort of a longitudinal Brazilian elderly study. Allele frequencies, genotype distribution, and association with major morbidities as well as with lipids, creatinine, albumin, urea, glycated hemoglobin, and fasting glucose serum levels were investigated. Linkage disequilibrium and haplotype associations were also analyzed. This is the first time that haplotypes involving these polymorphisms were evaluated. Genotyping was performed by PCR-RFLP. Minor allele frequencies were 0.119, 0.071, and 0.158 for XmnI, S19W, and -1131T>C polymorphisms, respectively. We found a significant association of the -1131C allele with low LDL-C levels. We also observed that XmnI and S19W polymorphisms were in linkage disequilibrium. The C/G haplotype, which is composed of the wild-type allele of XmnI and the minor allele of S19W, was associated with high total cholesterol serum levels in this elderly population. We conclude that the -1131T>C polymorphism and the C/G haplotype, including XmnI and S19W polymorphisms, are associated with alterations in lipid levels and may be risk factors for cardiovascular disease in the Brazilian elderly.

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“…Can Dermidöğen et al (2012) correlated the APOA5 S19W polymorphism with lipid parameters in a Turkish population. Also, the same rare allele was significantly associated with increased TG levels in a Spanish Mediterranean population (Ariza et al, 2010) and in Brazilians (De Andrade et al, 2011).…”

Section: Resultsmentioning

confidence: 81%

APOA5 polymorphisms associated with lipid metabolism in Brazilian children and adolescents

França¹,

Silva²,

Silva³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Single nucleotide polymorphisms in the APOA5 gene have been studied for their association with metabolic syndrome. Thus, elucidating the effect of the mechanism involved in APOA5 gene polymorphisms on lipid metabolism is of great importance. In this study we aimed to determine the allelic and genotypic frequencies of -1131T>C, Ser19Trp, and intergenic APOA4/A5 and to evaluate the association between these variants with plasma lipid levels in children and adolescents from Brazil. This study included 524 healthy children and adolescents from Mother and Child Hospital in Recife, Pernambuco, Brazil. Data were obtained on medical history, drug intake, lifestyle variables, and demography. DNA from collected samples was extracted and genotyped for the three polymorphisms. In this studied population, triglycerides and very low-density protein levels were significantly high in subjects carrying the 19WW genotype (P < 0.001), demonstrating the presence of this genetic risk factor in children and adolescents.

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The influence of the S19W SNP of the APOA5 gene on triglyceride levels in southern Brazil: Interactions with the APOE gene, sex and menopause status

Cited by 24 publications

References 31 publications

Gender-specific associations between lipids and cognitive decline in the elderly

Gender-specific associations between lipids and cognitive decline in the elderly

Short Communication Association of APOA1 and APOA5 polymorphisms and haplotypes with lipid parameters in a Brazilian elderly cohort

APOA5 polymorphisms associated with lipid metabolism in Brazilian children and adolescents

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