The Influence of the Sennosides on Absorption of Glycyrrhetic Acid in Rats

Mizuhara, Yasuharu; Takizawa, Yukiho; Ishihara, Kazuhisa; Asano, Takayuki; Morota, Takashi; Kase, Yoshio; Takeda, Susumu; Aburada, Masaki; Nomura, Masatoshi; Yokogawa, Koiçhi

doi:10.1248/bpb.28.1897

Cited by 14 publications

(9 citation statements)

References 32 publications

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“…Moreover, we should discuss the absorptive efficiency of Kampo medicine. However, it is not well known, although pharmacokinetics of some of compounds was investigated in clinical and basic researches [8, 9]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxygen Radical Absorbance Capacity in Kampo Medicine

Nishimura

Osawa

Watanabe

2011

Evidence-Based Complementary and Alternative Medicine

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Antioxidant capacity of food has come to be shown in terms of oxygen radical absorbance capacity (ORAC) mainly on vegetables or fruit. However, the evaluation of Kampo in terms of ORAC has not yet been accomplished. It is important that such an investigation is also conducted for Kampo medicine. We measured the ORAC value of almost all the available Kampo formulas used in the Japanese National health insurance system and examined the ORAC value both for the daily prescription, and also the crude herb ingredients. The ORAC value of Kampo medicine ranged 4.65–5913 units/day. The ORAC value was high in Kampo formulas including Rhei Rhizoma, and was relatively high in Kampo formulas including anti-inflammatory herbs other than Rhei Rhizoma. The ORAC value was also high in Kampo formulas including crude herbs that have relaxation effects. The ORAC value of a crude herb would seem to not be fixed but be dependent on combination with other crude herbs from the comparison of different herbs added to the basic Kampo medicine. These results suggest variability and complexity of the antioxidant capacity of Kampo medicine within the similar range of food. On the other hand, investigation of the compound changes of various crude herbs with ORAC may lead to the elucidation of the action mechanism of Kampo medicine.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Oxygen Radical Absorbance Capacity in Kampo Medicine

Nishimura

Osawa

Watanabe

2011

Evidence-Based Complementary and Alternative Medicine

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“…The aldosterone effects of licorice root may counteract antihypertensive action of prescribed medications (Cassileth and Barazzuol, 2001). Recently, a direct interaction of glycyrrhetinic acid absorption with sennosides and its derivatives has been studied in humans (Mizuhara et al, 2005). Some drug interactions of licorice which have been reported are summarized in Table 9.…”

Section: G Glabramentioning

confidence: 99%

Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

Nassiri‐Asl

Hosseinzadeh

2008

Phytotherapy Research

1,020

689

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The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener. Licorice root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, and pulmonary and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective and cardioprotective effects. A large number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoids and chalcones, with glycyrrhizic acid normally being considered to be the main biologically active component. This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components.

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“…Compared with glycyrrhizin, LLE pretreatment is a priority for the determination of glycyrrhetic acid with HPLC‐UV or LC‐MS systems (Ching et al ., 2002; Gao et al ., 2004; Ding et al ., 2006; Zhao et al ., 2008; Lin et al ., 2009; Zou et al ., 2009). A study employing enzyme immunoassay to detect glycyrrhetic acid in rat blood obtained good sensitivity and specificity (Mizuhara et al ., 2005). Both blood and liver concentration of glycyrrhizin were measured in two studies (Shibata et al ., 2000; Koga et al ., 2008), providing direct evidence that glycyrrhizin can reach liver tissue.…”

Section: Pharmacokinetic Application Of Herbal Medicines For the Treamentioning

confidence: 99%

Biological analysis of herbal medicines used for the treatment of liver diseases

Chien¹,

Wu²,

Tsai

2010

Biomedical Chromatography

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Herbal medicines have been used to treat liver disorders for thousands of years in the East and have now become a promising therapy internationally for pathological liver conditions. Biological analysis of hepatoprotective herbs is an important issue from the pharmacokinetic perspective in developing new therapeutic managements for liver disease. The biological analysis focuses on the pretreatment methods, separation and quantification of herbal medicines in biological samples. We have compiled and discuss the biological analytical method of six herbal medicines for liver protection containing Silybum marianum(silymarin), Glycyrrhiza glabra, Scutellaria baicalensis, Schisandra chinensis, Salvia miltiorrhiza and Astragalus membranaceus. This review provides a convenient reference for researchers to reduce time-consuming method optimization.

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The Influence of the Sennosides on Absorption of Glycyrrhetic Acid in Rats

Cited by 14 publications

References 32 publications

Evaluation of Oxygen Radical Absorbance Capacity in Kampo Medicine

Evaluation of Oxygen Radical Absorbance Capacity in Kampo Medicine

Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

Biological analysis of herbal medicines used for the treatment of liver diseases

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