The Influence of the Thyroids on the Functions of the Suprarenals

Herring, P. T.

doi:10.1210/endo-4-4-577

Cited by 10 publications

(2 citation statements)

References 31 publications

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“…It is long known that thyroid hypo-and hyperfunction alfect adrenal weight in rats [15]; furthermore, there are structural changes in the adrenals of genetically hypo thyroid mice [26]. Many metabolic interactions between thyroid and adrenocortical hormones have been also reported, the most striking of which is an increased catabolism of corticosteroids in hyperthyroid humans or Tj-treated rats, while the opposite oc curs in hypothyroidism [11,12, 23].…”

Section: Discussionmentioning

confidence: 99%

Effects of Neonatal and Adult Thyroid Dysfunction on Thymic Oxytocin

Argiolas¹,

Gl²,

Melis³

et al. 1990

Neuroendocrinology

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Prenatal plus neonatal administration of methimazole (MMI), a procedure provoking marked hypothyroidism in rats, increased by about 100% the thymic content of oxytocin and severely (by approximately 80%) decreased the thymus weight, compared to euthyroid counterparts. Adult-onset, propylthiouracyl (PTU)-induced hypothyroidism, while provoking thymic involution, or thyroxine (T4) hyperthyroidism, did not affect oxytocin concentrations. Thymic involution and increases in thymus oxytoxin could also be obtained with repeated administration of the potent glucocorticoid dexamethasone. However, since corticosterone, unless subchronically injected at largely supraphysiological doses, was previously shown to have no influence on thymic parameters of young adult rats, a major involvement of the neonatal adrenal axis in oxytocin alterations could be excluded. It is suggested that the ontogenesis of thymic oxytocin production is under thyroid control.

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Section: Discussionmentioning

confidence: 99%

Effects of Neonatal and Adult Thyroid Dysfunction on Thymic Oxytocin

Argiolas¹,

Gl²,

Melis³

et al. 1990

Neuroendocrinology

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“…Third, the persistence of a TR␤1-positive zone in adult females after pregnancy contrasts with the pregnancy-induced loss of a histological X-zone (12) and loss of 20␣HSD expression (14), suggesting that TR␤1 marks a novel cell population. Interestingly, it has been reported that thyroid gland extracts induce adrenocortical hypertrophy in species that lack a histologically identifiable X-zone, such as the guinea pig, rabbit, and cat (37). We speculate that in these species, a conserved TR␤1-positive cortical zone, rather than a histologically identified X-zone, may determine sensitivity to T 3 .…”

Section: A Tr␤1-positive Zone Of the Adrenal Inner Cortexmentioning

confidence: 77%

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1

et al. 2015

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The development of the adrenal cortex involves the formation and then subsequent regression of immature or fetal inner cell layers as the mature steroidogenic outer layers expand. However, controls over this remodeling, especially in the immature inner layer, are incompletely understood. Here we identify an inner cortical cell population that expresses thyroid hormone receptor-β1 (TRβ1), one of two receptor isoforms encoded by the Thrb gene. Using mice with a Thrb(b1) reporter allele that expresses lacZ instead of TRβ1, β-galactosidase was detected in the inner cortex from early stages. Expression peaked at juvenile ages in an inner zone that included cells expressing 20-α-hydroxysteroid dehydrogenase, a marker of the transient, so-called X-zone in mice. The β-galactosidase-positive zone displayed sexually dimorphic regression in males after approximately 4 weeks of age but persisted in females into adulthood in either nulliparous or parous states. T3 treatment promoted hypertrophy of inner cortical cells, induced some markers of mature cortical cells, and, in males, delayed the regression of the TRβ1-positive zone, suggesting that TRβ1 could partly divert the differentiation fate and counteract male-specific regression of inner zone cells. TRβ1-deficient mice were resistant to these actions of T3, supporting a functional role for TRβ1 in the inner cortex.

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Studies of the thyroid apparatus. XIV. The effects of thyro‐parathyroidectomy and parathyroidectomy at 100 days of age on the growth of the glands of internal secretion of male and female albino rats

Hammett

1923

Am. J. Anat.

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The Influence of the Thyroids on the Functions of the Suprarenals

Cited by 10 publications

References 31 publications

Effects of Neonatal and Adult Thyroid Dysfunction on Thymic Oxytocin

Effects of Neonatal and Adult Thyroid Dysfunction on Thymic Oxytocin

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1

Studies of the thyroid apparatus. XIV. The effects of thyro‐parathyroidectomy and parathyroidectomy at 100 days of age on the growth of the glands of internal secretion of male and female albino rats

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