The Influence of the λ Prophage on the Action of the Inducible Inhibitor of Postirradiation DNA Degradation

Induction of radioresistance in Escherichia coli

“…Since strains in which endolysin production was marginal still showed good inhibition it was suggested that the defective prophage is not necessary and that the inhibitor is induced independently of the prophage. This is further confirmed by work by Pollard et al (1975) where strains containing X-prophage and those without it are compared. The conclusion reached is that the inhibitor is a property with characteristics similar to phage induction but not the same as phage induction.…”

“…There is no sign of protection; no induction can occur. Postirradiation DNA degradation is extensive; no inducible inhibition is apparent (Pollard et al, 1975). Fig.…”

“…havior with a shoulder and a less negative slope appears. AB 1157 shows inhibited postirradiation DNA degradation which is increased by rifampin treatment and decreased by predoses of UV (Pollard et al, 1975).…”

“…Possibly the potentiation is related to this fact. Postirradiation DNA degradation has been observed to be extensive; no inducible inhibition is apparent (Pollard et al, 1975). FIGURE 5 CFA plots for strain AB2470 (recB-).…”

“…The phenomenon of radiation induction of factors involved with cellular response to radiation has been the subject of considerable study recently. In addition to the radiation induction of prophage, induction of filament formation (Witkin, 1967), reactivation of irradiated phage (Weigle, 1953;George et al, 1974), an error-prone repair system related to mutation (Witkin and George, 1973;Witkin, 1974), and the inducible inhibition of postirradiation DNA degradation (Grady and Pollard, 1968;Pollard and Randall, 1973;Marsden et al, 1974;Pollard et al, 1974;Pollard et al, 1975) have been observed.…”