The influence of trace elements on the therapeutic success of suprachoroidal draining devices

Wörn, Maximilian; Laemmer, Robert; Lucio, Marianna; Michalke, Bernhard; Rühl, Eva; Hohberger, Bettina

doi:10.1016/j.jtemb.2023.127195

Cited by 2 publications

References 58 publications

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Zinc dampens anti-tumour immunity by promoting Foxp3+ regulatory T cells

Awasthi,

Narayan,

Dalal

et al. 2023

Preprint

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The role of zinc (Zn) in tumor development and immune modulation has always been paradoxical. This study redefines our understanding of the impact of Zn on cancer progression and therapeutic strategies. Our findings show that high dietary Zn promotes tumor progression by fostering a pro-tumorigenic environment mediated by T cells. In contrast, deficiency in dietary Zn and chelation of tissue Zn emerge as potent drivers of anti-tumor immunity. We elucidated that increased Zn intake facilitates tumor progression by fostering Foxp3 + regulatory T cells (Tregs) frequency. Remarkably, we have pinpointed FOXO1 as the master regulator governing the influence of Zn on Tregs, elucidating a novel mechanistic insight. Finally, we introduce a promising therapeutic approach by showing that administering Clioquinol (CQ) significantly enhances αPD-1 immunotherapy response, particularly in melanoma. These revelations transform our comprehension of multifaceted role of Zn in tumorigenesis and immune regulation, highlighting innovative possibilities for cancer therapy.

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Zinc dampens anti-tumour immunity by promoting Foxp3+ regulatory T cells

Awasthi,

Narayan,

Dalal

et al. 2023

Preprint

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Zinc dampens antitumor immunity by promoting Foxp3+ regulatory T cells

Narayan,

Dalal,

Rizvi

et al. 2024

Front. Immunol.

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IntroductionThe role of zinc (Zn) in tumor development and immune modulation has always been paradoxical. This study redefines our understanding of the impact of Zn on cancer progression and therapeutic strategies.MethodsWe investigated the effects of dietary Zn levels on tumor progression and immune responses. This included examining the impact of both high and deficient dietary Zn, as well as Zn chelation, on tumor growth and immune cell populations. Specifically, we analyzed the frequency of Foxp3+ regulatory T-cells (Tregs) and identified the role of FOXO1 in Zn-mediated effects on Tregs. Additionally, we explored the therapeutic potential of clioquinol (CQ) in enhancing α-PD-1 immunotherapy responses, particularly in melanoma.ResultsOur findings show that high dietary Zn promotes tumor progression by fostering a protumorigenic environment mediated by T cells. Increased Zn intake was found to facilitate tumor progression by increasing Foxp3+ Treg frequency. In contrast, deficiency in dietary Zn and chelation of tissue Zn emerged as potent drivers of antitumor immunity. We pinpointed FOXO1 as the master regulator governing the influence of Zn on Tregs.DiscussionThese results reveal a novel mechanistic insight into how Zn influences tumor progression and immune regulation. The identification of FOXO1 as a key regulator opens new avenues for understanding the role of Zn in cancer biology. Furthermore, we introduce a promising therapeutic approach by showing that administering clioquinol (CQ) significantly enhances α-PD-1 immunotherapy response, particularly in melanoma. These revelations transform our comprehension of the multifaceted role of Zn in tumorigenesis and immune regulation, highlighting innovative possibilities for cancer therapy.

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The influence of trace elements on the therapeutic success of suprachoroidal draining devices

Cited by 2 publications

References 58 publications

Zinc dampens anti-tumour immunity by promoting Foxp3+ regulatory T cells

Zinc dampens anti-tumour immunity by promoting Foxp3+ regulatory T cells

Zinc dampens antitumor immunity by promoting Foxp3+ regulatory T cells

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