The influence of traditional Chinese herbal drugs on serum 1,5-anhydroglucitol levels

Kawasaki, Terukazu; Yamanouchi, Toshikazu; Kashiwabara, Akiko; Inoue, Takato; Yoshimura, Tomoe; Fujimori, Sin; Tanabe, Toshio; Aiso, Y.

doi:10.1016/s0168-8227(00)00167-4

Cited by 24 publications

(15 citation statements)

References 7 publications

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“…Our results suggest that the 1,5‐AG concentration in vitreous humor provides useful information for indirect evaluation of the blood glucose level before death. However, the discrepancy between the 1,5‐AG concentrations in the vitreous humor and CSF indicates a need to take into account the influence of diet , race , age , sex , medication , and clinical history, especially in cases with severe renal disease (chronic kidney disease (CKD) stage 4–5 , although the acute renal failure is generally much less than that of kidney disease ) and other pathological conditions . Furthermore, because the 1,5‐AG concentration in vitreous humor was slightly higher than that in CSF, there may be a need to evaluate 1,5‐AG in vitreous humor separately from that in the CSF to determine whether blood glucose control was worsening before death.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Postmortem 1,5‐anhydroglucitol in Vitreous Humor for Forensic Diagnosis

Takata

Yamasaki

Kitao

et al. 2015

Journal of Forensic Sciences

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In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhydroglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean±SD: 20.2 ± 8.7 μg/mL) and CSF (16.8 ± 8.7 μg/mL) did not differ significantly and showed a strong correlation (r(2) = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.

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Section: Discussionmentioning

confidence: 99%

Measurement of Postmortem 1,5‐anhydroglucitol in Vitreous Humor for Forensic Diagnosis

Takata

Yamasaki

Kitao

et al. 2015

Journal of Forensic Sciences

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“…There is no published report on plasma 1,5‐AG concentrations in children with renal or hepatic dysfunction. The Chinese herbal medicine such as Kampo increases, while acarbose lowers, the plasma 1,5‐AG levels in adult patients with T2DM (30, 31). There is no report on the effects of angiotensin converting enzyme (ACE) inhibitors on plasma 1,5‐AG levels in children or adults.…”

Section: Discussionmentioning

confidence: 99%

Serum 1,5-anhydroglucitol (Glycomark?) levels in children with and without type 1 diabetes mellitus

et al. 2007

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Postprandial hyperglycemia associated with diabetes is a risk factor for cardiovascular disease. Currently, glycated hemoglobin A(1c) (HgbA(1c)) and glycated protein fructosamine are not sensitive markers for acute and short-term hyperglycemia. 1,5-Anhydroglucitol (1,5-AG) (Glycomark; Tomen America, New York, NY, USA) is reported in adults with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) as a marker for postmeal hyperglycemia. However, the reference ranges for 1,5-AG in normal children and children with T1DM are not known. We studied 1,5-AG levels in 10 control children (6 males and 4 females) and 10 children with T1DM (7 males and 3 females). The levels of 1,5-AG in the normal controls were higher than those in children with T1DM (24.60 +/- 3.99 microg/mL vs. 4.75 +/- 2.95 microg/mL; p < 0.0001). There were no gender differences noted. The 1,5-AG levels were negatively correlated with HgbA(1c) (r =-0.9366; p < 0.0001) and the peak postmeal plasma glucose concentrations (Pearson r =-7230; p = 0.0003). Our findings suggest that despite good glycemic control, postprandial glucose concentrations are elevated and that 1,5-AG showed a difference between controls and children with T1DM. The data are comparable with previous studies in normal adults and in those with T1DM and T2DM. They support the use of 1,5-AG concentrations, together with HgbA(1c), to evaluate therapy, especially to target postprandial hyperglycemia.

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“…In addition, serum 1,5-AG shows an abnormally low level in conditions such as chronic renal failure in which reabsorption of 1,5-AG decreases [38][39][40] , pregnancy [41] , oxyhyperglycemia in which urinary glucose is observed transiently [42] , patients receiving long-term hyperalimentation [43] , and liver cirrhosis [44,45] . One of the causes of an abnormally high level of 1,5-AG is oral administration of a kind of Chinese medicines such as Ninjin-yoei-to and Kami-kihi-to which contain large amounts of 1,5-AG [46] . It is known that serum 1,5-AG during the neonatal period shows an apparently low level [47] .…”

Section: 5-anhydroglucitol In Neonatesmentioning

confidence: 99%

Glycemic control indicators in patients with neonatal diabetes mellitus

Suzuki¹,

Koga²

2014

WJD

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Neonatal diabetes mellitus (NDM) is a type of diabetes mellitus caused by genetic abnormality which develops in insulin dependent state within 6 mo after birth. HbA1c is widely used in clinical practice for diabetes mellitus as the gold standard glycemic control indicator; however, fetal hemoglobin (HbF) is the main hemoglobin in neonates and so HbA1c cannot be used as a glycemic control indicator in NDM. Glycated albumin (GA), another glycemic control indicator, is not affected by HbF. We reported that GA can be used as a glycemic control indicator in NDM. However, it was later found that because of increased metabolism of albumin, GA shows an apparently lower level in relation to plasma glucose in NDM; measures to solve this problem were needed. In this review, we outlined the most recent findings concerning glycemic control indicators in neonates or NDM.

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The influence of traditional Chinese herbal drugs on serum 1,5-anhydroglucitol levels

Cited by 24 publications

References 7 publications

Measurement of Postmortem 1,5‐anhydroglucitol in Vitreous Humor for Forensic Diagnosis

Measurement of Postmortem 1,5‐anhydroglucitol in Vitreous Humor for Forensic Diagnosis

Serum 1,5-anhydroglucitol (Glycomark?) levels in children with and without type 1 diabetes mellitus

Glycemic control indicators in patients with neonatal diabetes mellitus

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