THE INFLUENCE OF VARIOUS METABOLITES UPON THE p -AMINOBENZOATE-PANTOTHENATE INTERACTION IN BACTERIUM LINENS

Abstract

The nutritional equivalence of pantothenate and p-aminobenzoate for the growth of Bacterium linens and the reversal of growth inhibition by sulfanilamide and salicylate has indicated a biochemical relationship between pantothenate and p-aminobenzoate (Purko et al., 1953). Recently, Pomper (1952) observed that the pantothenate, as well as the methionine, histidine, and adenine requirements of a mutant of Saccharomyces cerevisiae, could be replaced by high p-aminobenzoate concentrations and also has

Biosynthesis of pantothenate

“…35 This activity was stimulated by the addition of divalent metal ions and to some extent by the addition of tetrahydrofolate. This finding was supported by earlier data that p-aminobenzoic acid (PABA) was involved in pantothenate metabolism [36][37][38] and suggested a mechanism analogous to that reported for serine hydroxymethyltransferase. 39 The enzyme was purified to a greater level of homogeneity by Teller et al 40 and this purified enzyme preparation was found to be dependent on 5,10-methylenetetrahydrofolate.…”