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The nutritional equivalence of pantothenate and p-aminobenzoate for the growth of Bacterium linens and the reversal of growth inhibition by sulfanilamide and salicylate has indicated a biochemical relationship between pantothenate and p-aminobenzoate (Purko et al., 1953). Recently, Pomper (1952) observed that the pantothenate, as well as the methionine, histidine, and adenine requirements of a mutant of Saccharomyces cerevisiae, could be replaced by high p-aminobenzoate concentrations and also has