The influence of vitamin C on the interaction between acute mental stress and endothelial function

Plotnick, Meghan; D'Urzo, Katrina A; Gurd, Brendon J.; Pyke, Kyra E.

doi:10.1007/s00421-017-3655-4

Cited by 13 publications

(19 citation statements)

References 49 publications

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“…However, Vitamin C insufficiencies (including not only deficiency but hypovitaminosis and inadequate plasma levels) may partly explain the increased incidence of chronic inflammation common to numerous chronic diseases as well as highlight potential hindrances in immune system defense. There are multiple known Vitamin C-lowering components including stress [31,32], poverty [4,33], obesity [34,35], and smoking [36][37][38]. Coupled with Western low nutritionally dense, the need for plasma Vitamin C assessment in routine screenings as well as admission to inpatient settings becomes more apparent.…”

Section: Introductionmentioning

confidence: 99%

Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003–2006

et al. 2021

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Vitamin C, well-established in immune function and a key factor in epigenetic inflammatory modifications, is only obtained through consistent dietary intake. Identifying individuals at risk for Vitamin C insufficiency may guide prevention and treatment, however, national surveillance has not been evaluated in the United States since 2006. A descriptive, cross-sectional secondary analysis was performed utilizing data from the 2003–2006 National Health and Nutrition Examination Surveys (NHANES) assessing non-institutionalized adults. Five categories of plasma Vitamin C were delineated: deficiency (<11 μmol/L), hypovitaminosis (11–23 μmol/L), inadequate (23–49 μmol/L), adequate (50–69 μmol/L), and saturating (≥70 μmol/L). Results indicated 41.8% of the population possessed insufficient levels (deficiency, hypovitaminosis, and inadequate) of Vitamin C. Males, adults aged 20–59, Black and Mexican Americans, smokers, individuals with increased BMI, middle and high poverty to income ratio and food insecurity were significantly associated with insufficient Vitamin C plasma levels. Plasma Vitamin C levels reveal a large proportion of the population still at risk for inflammatory driven disease with little to no symptoms of Vitamin C hypovitaminosis. Recognition and regulation of the health impact of Vitamin C support the goal of Nutrition and Healthy Eating as part of the Healthy People 2030.

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Section: Introductionmentioning

confidence: 99%

Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003–2006

et al. 2021

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“…The suggested mechanism is that this may be an indirect effect of the signi cant increased NO plasma level or directly due to the signi cant elevated level of ROS and RNS. Meanwhile, the previous study [27] has not proved the tightly bound to that hypothesized subcellular event. In our study, we proved these suggestions through nding the dose-dependent response according to the plasma NO levels.…”

Section: Discussionmentioning

confidence: 85%

“…Moreover, it has been previously published that SHR rats showed increased NO synthase activity (NOS) III in the cardiac and aortic endothelia. Both of these two enzymes helps in regulating the vasoreactivity in the SHR rats [27].…”

Section: Discussionmentioning

confidence: 99%

“…We chose the rat model since rats are more similar to human physiology over mice model, making them better models for the studying pathological conditions in pre-clinical trials [37,38]. Moreover, high sucrose/fat diet (HSF) induces hypertension rats; called spontaneously hypertensive rats (SHR) which are extensively used as an in vivo model for essential hypertension and cardiovascular disease [27]. This SHR rat model has elevated basal myocardial NO content which may be due to an Loading [MathJax]/jax/output/CommonHTML/jax.js increase in the protein-bound of dinitrosyl nonheme iron complexes which liberates the NO to the peripheral circulation that helps in treating the hypertensive state.…”

Section: Discussionmentioning

confidence: 99%

“…As previously described in [27], Forty-two 14-week-old male Wistar rats High Sucrose/Fat (HSF) fed (body weight, 403.19±18.12 g) obtained from the Animal House facilities, University of Tabuk, Saudi Arabia were divided into seven groups in a random manner. Rats were placed in conventional cages (3 rats/cage).…”

Section: Animal Treatmentmentioning

confidence: 99%

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Preclinical Study on the Ameliorating Effect of L-Ascorbic Acid for the Oxidative Stress of Caused by Chronic Administration of Organic Nitrates in Cardiovascular Diseases

Hamdan

Mohammedsaleh

Aboelnour

et al. 2021

Preprint

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PurposeThe therapeutic activity of Glyceryl trinitrate (GTN) is mainly regulated by liberating nitric oxide (NO) and reactive nitrogen species (RNS). During this biotransformation, oxidative stress and lipid peroxidation inside the red blood cells (RBCs) occur. The principal objective of our research is to explain the ameliorating effect of L-ascorbic acid for the deleterious effects of chronic administration of nitrovasodilator drugs. MethodsWe studied some biochemical parameters for the oxidative stress using groups of high sucrose/fat (HSF) diet Wistar male rats chronically orally administered ISMN. Afterwards, we evaluated the role of L-ascorbic acid against these biochemical changes. ResultsChronic treatment with organic nitrates caused elevated serum levels of lipid peroxidation, hemoglobin derivatives as methemoglobin and carboxyhemoglobin, rate of hemoglobin autoxidation, the cellular levels of pro-inflammatory cytokines marker (NF-κB) and apoptosis markers (caspase-3) in myocardium muscles in a dose dependent manner. Meanwhile, such exposure caused decline in the enzymatic effect of superoxide dismutase (SOD), glutathione (GSH) and catalase activity (CAT) accompanied with a decrease of in the level of mitochondrial oxidative stress marker (nrf2) in myocardium muscles and decrease in the serum iron and total iron binding capacity (TIBC) in a dose dependent manner. Concomitant treatment with L-ascorbic acid significantly diminished these changes for all examined parameters.ConclusionChronic administration of organic nitrates leads to the alteration of the level of oxidative stress factors in the myocardium tissue due to generation of reactive oxygen species. Using vitamin C can effectively ameliorate such intoxication to overcome the nitrate tolerance.

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The impact of acute mental stress on brachial artery flow-mediated dilation in women diagnosed with depression

D'Urzo

Rocque

Williams

et al. 2019

International Journal of Psychophysiology

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The influence of vitamin C on the interaction between acute mental stress and endothelial function

Cited by 13 publications

References 49 publications

Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003–2006

Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003–2006

Preclinical Study on the Ameliorating Effect of L-Ascorbic Acid for the Oxidative Stress of Caused by Chronic Administration of Organic Nitrates in Cardiovascular Diseases

The impact of acute mental stress on brachial artery flow-mediated dilation in women diagnosed with depression

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