The empirical interpretation of cone penetration test (CPT) cone factors (
N
k
) can be subject to considerable variability for clays derived from weathered mudstones, leading to significant deviations in the estimation of undrained shear strength (
S
u
). This paper presents a comparison of triaxial and CPT data from a site investigation in clays derived from weathered mudstones in central England. Corrected cone factors (
N
kt,UU
) were derived from a one-to-one comparison of 94 pairs of unconsolidated, undrained triaxial and CPT data from equivalent depths. The performance of the cone factors was evaluated using a training set (75 pairs) and a test set (19 pairs). A parametric study was used to explore the variability of
N
kt,UU
, quantified using the coefficient of variation (COV
Nkt,UU
), for varied separation distance thresholds (
D
s
) between individual triaxial and CPT test data. The absolute deviation between the laboratory shear strength (
S
u(Lab)
) and that predicted from CPT profiles (S
u(
CPT)
) was not sensitive to
N
kt,UU
values in the range 25 <
N
kt,UU
< 31. The parametric study showed that
D
s
could be increased from 50 m to 250 m, to include more data pairs for estimates of
N
kt,UU
, without substantially increasing COV
Nkt,UU
.