The infrapatellar fat pad in knee osteoarthritis: An important source of interleukin‐6 and its soluble receptor

Distel, Emilie; Cadoudal, Thomas; Durant, Sylvie; Poignard, Alexandre; Chevalier, Xavier; Benelli, C

doi:10.1002/art.24881

Cited by 201 publications

(182 citation statements)

References 13 publications

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“…When the subcutaneous fat tissue (SCFT) and fat pad tissue (FPT)-derived cells were compared, IPFP adipocytes showed a twofold increase in IL-6 gene expression and in IL-6 release. Interestingly, leptin secretion was 40 % lower and adiponectin was increased by 70 % in IPFP cells compared with the subcutaneous adipose tissue [73]. Moreover, it was demonstrated that the culture media from OA patients' IPFP adipocytes induced MMP13 and MMP1 expression in articular chondrocytes and that the leptin level positively correlated with the expression of both MMPs and cartilage collagen destruction [20].…”

Section: Adipocytokines Secretion By Infrapatellar Fat Padmentioning

confidence: 98%

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Richter

Trzeciak

Owecki

et al. 2015

International Orthopaedics (SICOT)

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Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.

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Section: Adipocytokines Secretion By Infrapatellar Fat Padmentioning

confidence: 98%

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Richter

Trzeciak

Owecki

et al. 2015

International Orthopaedics (SICOT)

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“…Likewise, in cultured chondrocytes, as already mentioned for RA, adiponectin also induces the production of proinflammatory and matrix catabolic factors (96). In keeping with all of these activities for adiponectin in OA, it has been determined that the infrapatellar fat pad of knee OA has an increased synthesis of adiponectin that suggests the infrapatellar fat pad as a possible source of joint adiponectin (105).…”

Section: Adiponectin and Rheumatic Diseasesmentioning

confidence: 61%

Cardiometabolic comorbidities and rheumatic diseases: Focus on the role of fat mass and adipokines

Lago¹,

Gómez²,

Conde³

et al. 2011

Arthritis Care & Research

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“…The knee joint is the only joint in which there is localized adipose tissue, recognized also as being metabolically active [20][21][22][23]25], and the joint most often affected by OA. While previous…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the knee likely provides an ideal setting in which to examine any potential role(s) of fat on OA development/progression, particularly as it is the only joint to contain a large intra-articular deposit of adipose tissue. The infrapatellar fat pad (IFP) is an intracapsular and extrasynovial structure, distinguishable from SAT and VAT by its unique location and relative size [19][20][21][22][23][24]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gene Expression Profiles of the Subcutaneous Fat and Infrapatellar Fatpad in Individuals with Early and Endstage Knee Osteoarthritis: A Cross-sectional Analysis

Weston¹

2015

J Arthritis

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IntroductionThere is now compelling evidence that adipose tissue is metabolically active and that adipose derived metabolic factors can have physiological effects [1,2]. In adults, fat exists primarily as white adipose tissue. This tissue is widely distributed throughout the body with the two most prevalent forms being subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT).SAT accounts for the vast majority of all the fat in the body [3,4] and potentially is a major source of adipose derived factors in the systemic circulation [5]. Each type of adipose tissue displays unique phenotypic and genotypic characteristics [6]. Some have suggested that each fat type may have differing developmental lineages that play a role in body fat distribution, obesity and the variety of functional properties of various adipose tissue sites in the body [7]. Previous work has shown that inflammatory hormones secreted by adipocytes and macrophages can significantly affect expression levels of leptin, adiponectin, tumour necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in SAT [1,[8][9][10]. The systemic release of these adipose-derived hormones is thought to be responsible for the low-grade inflammatory state commonly observed in obese individuals [6,11,12].The link between obesity and osteoarthritis (OA) has long been established [13]. This link is in part believed to be a metabolic one [13], in addition to the recognized impact of increasing mechanical forces on weight-bearing joints [12]. Many individuals experience OA symptoms in non-weight bearing joints as well [14][15][16]. Indeed, studies are revealing associations between levels of adipose-derived factors in blood and/or synovial fluid and the presence or severity of osteoarthritis, particularly the knee [17,18].Osteoarthritis is most prevalent in the knee [15], and association between OA and obesity has been particularly marked for this joint [16]. Thus, the knee likely provides an ideal setting in which to examine any potential role(s) of fat on OA development/progression, particularly as it is the only joint to contain a large intra-articular deposit of adipose tissue. The infrapatellar fat pad (IFP) is an intracapsular and extrasynovial structure, distinguishable from SAT and VAT by its unique location and relative size [19][20][21][22][23][24]. AbstractObjective: Previous research has examined gene expression of the IFP from individuals with early and endstage knee OA. However, there is little understanding of whether the differential expression that was found is a local effect associated with OA disease severity. The objective of this study was to compare gene expression of the SAT and IFP both within individuals with early and late stage knee OA.Methods: Knee SAT and corresponding IFP samples were harvested from twenty-nine patients with endstage and five patients with early stage OA at the time of knee surgery. Total RNA was then extracted, labelled and hybridized to Illumina whole genome expression arrays. Arrays were scanned and intensity of hybridi...

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The infrapatellar fat pad in knee osteoarthritis: An important source of interleukin‐6 and its soluble receptor

Cited by 201 publications

References 13 publications

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Cardiometabolic comorbidities and rheumatic diseases: Focus on the role of fat mass and adipokines

Gene Expression Profiles of the Subcutaneous Fat and Infrapatellar Fatpad in Individuals with Early and Endstage Knee Osteoarthritis: A Cross-sectional Analysis

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