The inhibitory effect of chitosan oligosaccharides on β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells

Dai, Xueling; Chang, Peng; Li, Xiaoxiao; Gao, Zhaolan; Sun, Yijian

doi:10.1016/j.neulet.2017.11.052

Cited by 15 publications

(13 citation statements)

References 27 publications

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“…Oligosaccharides play crucial roles in a wide range of biological processes, such as cellular communication, pathogenesis and prebiotic functions [ 1 , 2 , 3 , 4 , 5 ]. For this reason, they are also being developed for new drugs.…”

Section: Introductionmentioning

confidence: 99%

Structural Features of Sulfated Glucuronomannan Oligosaccharides and Their Antioxidant Activity

et al. 2018

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Glucuronomannan oligosaccharides (Gs) were derived from fucoidan, which was extracted from the brown alga Sargassum thunbergii. Sulfated glucuronomannan oligosaccharides (SGs) were obtained by the sulfation of Gs. NMR techniques were used to reveal that the order of sulfation was Man-C6 > Man-C4 > Man-C1R > GlcA-C3 > Man-C3 > GlcA-C2. Finally, the antioxidant activities (hydroxyl radical scavenging activity, superoxide radical scavenging activity, reducing power and DPPH radical scavenging activity) of Gs and SGs were determined. The findings showed that the higher the degree of polymerization, the better the activity, except for the hydroxyl radical scavenging activity. In addition, the higher the sulfate content, the lower the activities for the reducing power and DPPH radical scavenging activity. Opposite results were found for the superoxide radical scavenging activity. Finally, compared with fucoidan, most Gs and SGs had higher antioxidant activity, suggesting that they might be good candidates for antioxidants.

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Section: Introductionmentioning

confidence: 99%

Structural Features of Sulfated Glucuronomannan Oligosaccharides and Their Antioxidant Activity

et al. 2018

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“…Furthermore, caffeic acid conjugated chitosan oligosaccharide effectively inhibited β-site amyloid precursor protein-cleaving enzyme activity, which was the rate limiting step of Aβ peptide formation in Alzheimer's disease [39]. Interestingly, chitosan oligosaccharide at 500 µg/mL inhibited β-site amyloid precursor protein cleaving enzyme 1 (BACE1) activity and protein expression in HEK293 APPswe cells [40]. Chitosan oligosaccharide inhibited αβ aggregation, inhibited Aβ1-42 fibrils formation, and induced fibril destabilization in oligomeric Aβ-induced neurotoxicity and oxidative stress in rat hippocampal neurons [41].…”

Section: Neurological and Musculoskeletal Diseasesmentioning

confidence: 99%

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

Satitsri

Muanprasat

2020

Molecules

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Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.

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“…Besides, their results suggested that COS could disintegrate Aβ 1-42 fibrils formation, implying that COS has both anti-Aβ fibrillogenesis and fibril-destabilizing ability [111]. Recently, Dai et al proposed that COS exerted its neuroprotective effect partly through suppressing β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) expression and enzymatic activity [112]. Eom et al prepared various phenolic acid-conjugated COS like hydroxyl cinnamic acid and hydroxyl benzoic acid to explore their inhibitory effect on BACE, and the results indicated that caffeic acid-conjugated COS was most effective in repressing BACE and ameliorating AD [113].…”

Section: Biological Functions Of Cosmentioning

confidence: 99%

A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide

Liang

Sun

Dai

2018

IJMS

Self Cite

126

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Chitooligosaccharide (COS), which is acknowledged for possessing multiple functions, is a kind of low-molecular-weight polymer prepared by degrading chitosan via enzymatic, chemical methods, etc. COS has comprehensive applications in various fields including food, agriculture, pharmacy, clinical therapy, and environmental industries. Besides having excellent properties such as biodegradability, biocompatibility, adsorptive abilities and non-toxicity like chitin and chitosan, COS has better solubility. In addition, COS has strong biological functions including anti-inflammatory, antitumor, immunomodulatory, neuroprotective effects, etc. The present paper has summarized the preparation methods, analytical techniques and biological functions to provide an overall understanding of the application of COS.

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The inhibitory effect of chitosan oligosaccharides on β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells

Cited by 15 publications

References 27 publications

Structural Features of Sulfated Glucuronomannan Oligosaccharides and Their Antioxidant Activity

Structural Features of Sulfated Glucuronomannan Oligosaccharides and Their Antioxidant Activity

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide

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