The inhibitory effect of granisetron on ventrolateral medulla neuron responses to colorectal distension in rats

Panteleev, S. S.; Martseva, A. A.; Lyubashina, O. A.

doi:10.1016/j.ejphar.2015.01.002

Cited by 12 publications

(3 citation statements)

References 56 publications

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“…In these animals, a different mechanism, other than duodenal serotonin release and vagal 5‐HT 3 receptors activation, must be involved in visceral pain inhibition. Recently, 5‐HT 3 receptors were demonstrated to be involved in abdominal pain transmission within the ventrolateral medulla, occurring in response to noxious colorectal distension . Although the origin of serotonin released in those experiments was not determined, in conditions of colonic hypersensitization, like irritable bowel syndrome (IBS), serotonin may be released from intestinal mast cells, contributing to abdominal pain .…”

Section: Discussionmentioning

confidence: 99%

Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron

Martín‐Ruíz

Uranga

Mosińska

et al. 2018

Neurogastroenterology Motil

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Background Cisplatin is a highly emetogenic antineoplastic drug and induces peripheral neuropathy when given in cycles. Granisetron, a 5‐HT3 antagonist, is clinically used to prevent chemotherapy‐induced nausea/emesis and abdominal pain in irritable bowel syndrome. The effects of cisplatin on visceral sensitivity and those of granisetron in the context of cancer chemotherapy are not well known. Methods Adult male Wistar rats received two intraperitoneal injections 30 minutes apart: granisetron (1 mg kg−1)/vehicle and cisplatin (6 mg kg−1)/vehicle. Thereafter, nausea‐like behavior was measured as bedding intake for 4 hours, and gastric dysmotility was measured radiographically for 8 hours. Gastric weight and size were determined ex vivo and samples of the forestomach, corpus, ileum, and colon were obtained for histological analysis at 4 and 30 hours after cisplatin/vehicle. Visceral sensitivity was measured as abdominal contractions in response to mechanical intracolonic stimulation 2 hours after cisplatin/vehicle. Key Results Cisplatin‐induced bedding intake and gastric dysmotility, and granisetron blocked these effects, which occurred in the absence of frank mucositis. Visceral sensitivity was reduced to a similar extent by both drugs alone or in combination. Conclusions and Inferences Cisplatin‐induced bedding intake and gastric dysmotility were blocked by granisetron, confirming the involvement of serotonin acting on 5‐HT3 receptors. Unexpectedly, visceral sensitivity to colonic distension was reduced, to the same extent, by cisplatin, granisetron, and their combination, suggesting important mechanistic differences with nausea and gastric dysmotility that warrant further investigation.

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Section: Discussionmentioning

confidence: 99%

Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron

Martín‐Ruíz

Uranga

Mosińska

et al. 2018

Neurogastroenterology Motil

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“…For example, there are clinical data demonstrating that setrons exert analgesic effect on both extracranial pain syndromes and various orofacial pain . Setrons have been reported to display analgesic, anti‐allodynic and anti‐hyperalgesic activities in animal models not only of non‐trigeminal, but also of trigeminal nociception . The latter is of particular interest since the trigeminal nerve, being functionally integrated together with the cranial blood vessels into the trigeminovascular system, plays a pivotal role in the pathogenesis of every cephalalgia .…”

Section: Introductionmentioning

confidence: 99%

“…For example, there are clinical data demonstrating that setrons exert analgesic effect on both extracranial pain syndromes 5,6 and various orofacial pain. 7,8 Setrons have been reported to display analgesic, anti-allodynic and anti-hyperalgesic activities in animal models not only of non-trigeminal, 9,10 but also of trigeminal nociception. [11][12][13] The latter is of particular interest since the trigeminal Summary One way to expand the existing range of anti-migraine drugs seems to be the search for pharmacological agents with anti-cephalalgic properties among medicines approved for clinical indications other than migraine.…”

Section: Introductionmentioning

confidence: 99%

Blockade of 5‐HT3 receptors with granisetron does not affect trigeminothalamic nociceptive transmission in rats: Implication for migraine

Sokolov

Sivachenko

Panteleev

et al. 2017

Clin Exp Pharma Physio

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Summary One way to expand the existing range of anti‐migraine drugs seems to be the search for pharmacological agents with anti‐cephalalgic properties among medicines approved for clinical indications other than migraine. Numerous experimental and clinical data imply that selective serotonin 5‐HT3 receptor antagonists can be considered as potential anti‐migraine agents. Therefore, the objective of our work was to examine the impact of selective 5‐HT3 receptor blockade with granisetron on migraine‐related nociceptive transmission within the spinal trigeminal nucleus (STN) and the ventroposteromedial nucleus of the thalamus (VPM). Using an electrophysiological model of trigemino‐durovascular nociception in anaesthetised male Wistar rats, we evaluated the effects of intravenous administration of granisetron on ongoing firing and dural electrical stimulation‐evoked responses of the spinal trigeminal and thalamic cells. Granisetron did not substantially affect responses of the STN and VPM neurons to electrical stimulation of the dura mater as well as did not cause steady changes in ongoing firing of the spinal trigeminal cells. The results obtained argue against the use of 5‐HT3 receptor antagonists for treating migraine. These data also lead to the conclusion that in the absence of sustained sensitisation of neurons along the trigemino‐thalamo‐cortical pathway the role of 5‐HT3 receptor‐dependent mechanisms in serotonergic modulation of trigeminovascular nociceptive transmission can hardly be considered crucial.

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Supraspinal Mechanisms of Intestinal Hypersensitivity

2020

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The inhibitory effect of granisetron on ventrolateral medulla neuron responses to colorectal distension in rats

Cited by 12 publications

References 56 publications

Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron

Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron

Blockade of 5‐HT3 receptors with granisetron does not affect trigeminothalamic nociceptive transmission in rats: Implication for migraine

Supraspinal Mechanisms of Intestinal Hypersensitivity

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