The inhibitory effect of Zingiber corallinum Hance essential oil on drug-resistant bacteria and evaluation of its acute toxicity

Yang, Chen; Zhou, Lingsha; Wang, Haiyan; Huang, Suna; Liu, Qing; Shilin, Hu; Li, Ting-Rong; Chen, Yanbing; Jiang, Jianxin

doi:10.12659/msm.881760

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…Because all these positive interactions occur when components of essential oils are present, the results emphasize the potential of this class of phytochemicals for combinatorial therapy with antibiotics. In fact, this is supported by previous studies about the effects of essential oils and their constituents in the control of multidrug-resistant bacteria [21][22][23]. Kuroda et al demonstrated that farnesol at a sub-MIC inhibited S. aureus lipase (SAL) against 8 methicillin-susceptible and 31 methicillin-resistant S. aureus clinical isolates [24].…”

Section: Discussionmentioning

confidence: 77%

Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections

et al. 2022

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Diabetic foot ulcers (DFUs) are a common result of a complex secondary complication of diabetes mellitus. More than half of DFUs become infected due to frequent colonization with Staphylococcus aureus. The use of topical antibiotics is proposed, especially in combination with natural adjuvants, to minimize the negative impacts caused by generalized use of systemic antibiotics. In this study, 13 different phytochemicals—namely chalcone, juglone, cinnamic acid, trigonelline, Furvina—and four nitrovinylfuran derivatives—guaiazulene, α-bisabolol, farnesol and nerolidol—were selected to be tested as antibiotic enhancers. After minimum inhibitory and bactericidal concentration (MIC and MBC) determination of each molecule against different strains of S. aureus, including clinical isolates from diabetic foot wounds (CECT 976, Xu212, SA 1199B, RN4220, MJMC102, MJMC109, MJMC110 and MJMC111), their potentiation effects on the antibiotics fusidic acid, mupirocin, gentamicin, oxacillin and methicillin were evaluated through the disc diffusion method. Farnesol at sub-MIC was able to restore the activity of methicillin and oxacillin on the MJMC102 and MJMC111 strains, as well as two MRSA clinical isolates, and potentiated the effect of the remaining antibiotics. The results obtained demonstrate the great potential for the topical application of phytochemicals and derivatives as antibiotic resistance modifier agents to combat multidrug resistance in bacterial wound infections.

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Section: Discussionmentioning

confidence: 77%

Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections

et al. 2022

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“…MAC has been complete chemically defined and it was demonstrated that its antimicrobial activity could be principally attributed to terpinen-4-ol, the main active component [37,38,40,42,43,44]. Actually, terpinen-4-ol is the main bioactive antimicrobial component of essential oils derived from several aromatic plants [45,46,47]. On account of this, the interaction of terpinen-4-ol and the influenza virus haemagglutinin protein was predicted in silico to confirm the exact target and its active characteristics.…”

Section: Resultsmentioning

confidence: 99%

Melaleuca alternifolia Concentrate Inhibits in Vitro Entry of Influenza Virus into Host Cells

Duan

Chu

et al. 2013

Molecules

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Influenza virus causes high morbidity among the infected population annually and occasionally the spread of pandemics. Melaleuca alternifolia Concentrate (MAC) is an essential oil derived from a native Australian tea tree. Our aim was to investigate whether MAC has any in vitro inhibitory effect on influenza virus infection and what mechanism does the MAC use to fight the virus infection. In this study, the antiviral activity of MAC was examined by its inhibition of cytopathic effects. In silico prediction was performed to OPEN ACCESSMolecules 2013, 18 9551 evaluate the interaction between MAC and the viral haemagglutinin. We found that when the influenza virus was incubated with 0.010% MAC for one hour, no cytopathic effect on MDCK cells was found after the virus infection and no immunofluorescence signal was detected in the host cells. Electron microscopy showed that the virus treated with MAC retained its structural integrity. By computational simulations, we found that terpinen-4-ol, which is the major bioactive component of MAC, could combine with the membrane fusion site of haemagglutinin. Thus, we proved that MAC could prevent influenza virus from entering the host cells by disturbing the normal viral membrane fusion procedure.

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“…Our daily oral gavage doses were 8nL/g and 0.1nL/g diluted in purified water. These doses represent, respectively, 0.73% and 0.09% of the TP-4-ol Lethal dose (Yang et al 2011).…”

Section: Terpinen-4-ol Treatmentmentioning

confidence: 99%

Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model

Neto

Sorbo

Filho

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Our aim was to verify the modulative TP-4-ol capacity in 4-nitroquinoline-1-oxide induced oral rat cancer. Methods: The stereoisomers of TP-4-ol were used against the human tongue squamous cell line and the negative stereoisomer showed lower IC50. 31 Holtzman rats (120-130 grams) were cancer induced by 4-nitroquinoline-1-oxide (4-NQO/8 weeks/25 ppm) and 32 Holtzman rats (120-130 grams) were used to Healthy and TP-4-ol toxicity experiments. Six groups were used, healthy, 0.1nL/g of TP-4-ol, 8nL/g of TP-4-ol, 4-NQO, 4-NQO+0.1nL/g of TP-4-ol and 4-NQO+8nL/g of TP-4-ol. We performed the toxicity analysis by biochemical and histopathological analysis. The biochemistry analysis includes alkaline phosphatase [ALP], alanine aminotransferase [ALT], aspartate transaminase [AST], Urea and Creatinine and the histopathology analysis includes the liver, kidney, lung, and spleen. Specifically, for malign modulation we performed a macroscopic and microscopic analysis. Results: The group exposed to 0.1nL/g of TP-4-ol demonstrated a reduced risk of malignancy in dysplasia considering the criteria of architecture and cytology. Similarly, a drop of percentual rats with SCC diagnosis was observed in 4-NQO+0.1nL/g (41.6%) when compared to 4-NQO (87.5%). Moreover, the 4-NQO group presented a median of 2.62 SCC/rat and the 4-NQO+0.1nL/g demonstrated a median of 0.75 SCC/rat. For toxicity analysis, 4-NQO+0.1nL/g showed focal necrosis in the kidney and 4-NQO showed lung hemorrhagic areas. Conclusion: The concentration of 0.1nL/g was more effective in reducing the tongue induction of potentially malignant and malignant lesions by 4-NQO. A kidney toxicity was observed in healthy animals exposed to 0.1nL/g of TP-4-ol. Clinical relevance:The negative isoform of Terpinen-4-ol negatively modulates the development of potentially malignant and malignant lesions in rats (Rattus nonverdicts albinos, Holtzman) exposed to 4-NQO. (-)-Terpinen-4-ol reduced the mice percentual with squamous cell carcinoma, 87.5% to 41.6% and decreased the cancer/rat ratio of 2.62 in 4-NQO to 0.75 in 4-NQO+0.1nL/g. This represents 52.4% by group and 71.3% in the cancer/rat ratio.

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The inhibitory effect of Zingiber corallinum Hance essential oil on drug-resistant bacteria and evaluation of its acute toxicity

Cited by 9 publications

References 39 publications

Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections

Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections

Melaleuca alternifolia Concentrate Inhibits in Vitro Entry of Influenza Virus into Host Cells

Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model

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