The initial manifestations and final diagnosis of patients with high and low titers of antinuclear antibodies after 6 months of follow-up

Wang, Kun-Yi; Yang, Yao‐Hsu; Chuang, Ya Hui; Chan, Pei-Jung; Yu, Hsin-Hui; Lee, Jyh‐Hong; Wang, Li‐Chieh; Chiang, Bor‐Luen

doi:10.1016/j.jmii.2011.01.019

Cited by 24 publications

(23 citation statements)

References 20 publications

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“…Although ANA may be influenced by nonimmune factors, several articles show that the positive frequency is no more than 5% at a dilution titer of 1:160 in the general population. 10,15 In our study, at the cutoff value of 1:320 titer, we found a similar result to previous studies in that older people were prone to higher frequency of ANA positivity than younger people ( Figure 2 ).…”

Section: Discussionsupporting

confidence: 90%

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The Prevalence of Antinuclear Antibodies in the General Population of China: A Cross-Sectional Study

Guo¹,

Wang²,

Liu³

et al. 2014

Current Therapeutic Research

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BackgroundThe incidence of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and primary biliary cirrhosis has increased significantly in China. Information about the susceptibility or potential of autoimmune diseases in the general population is lacking.ObjectiveTo explore the prevalence of antinuclear antibody (ANA) and its specificities in the general population in China.MethodsTwenty thousand nine hundred seventy sera samples were taken from the physical examination center in Baoding, China. Indirect immunofluorescence and line immunoassays were used to detect ANA and its specificities, respectively.ResultsSamples from females had a higher prevalence of ANA than samples from males (χ2 = 278.55; P < 0.01). For both sexes, the prevalence of ANA positively correlated with age and there were significant differences among different age groups at 10-year intervals, except the 80 years group (P < 0.05). One thousand two hundred forty-three ANA-positive samples were further analyzed with line immunoassays. There was a significant difference among age groups and between sex groups in terms of the specific autoantibodies (P < 0.01). The autoantibodies with the top-3 positive frequencies were anti-Ro-52, anti-M2, and anti-SSA.ConclusionsThere was a high prevalence of ANA positivity in the general Chinese population that seemed to be influenced by sex and age and correlated with specific autoantibodies.

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Section: Discussionsupporting

confidence: 90%

“…Ro-52/SSA is a useful serologic marker for SLE and Sjogren syndrome, myositis, systemic sclerosis, and PBC. 15 Anti-Ro/SSA and antichromatin had the highest predictive value for SLE diagnosis. 16,17 In our study the positive rate of anti-M2 reached 12.7%.…”

Section: Discussionmentioning

confidence: 93%

The Prevalence of Antinuclear Antibodies in the General Population of China: A Cross-Sectional Study

Guo¹,

Wang²,

Liu³

et al. 2014

Current Therapeutic Research

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“…IIF was compared with immunodot assay to predict the specific antibodies associated with a specific pattern. 3%), and nucleolar (7.9%) except nucleolar prevalence which was similar to our study (25)(26). These differences may be due to the ethnic variations and biological heterogeneity of serological immune…”

Section: Discussionsupporting

confidence: 88%

The incidence of immunofluorescence patterns and specific autoantibodies observed in autoimmune patients in a tertiary care centre

Chauhan

Jain

Dorwal

et al. 2019

Eur Ann Allergy Clin Immunol

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Objectives. Testing for antinuclear antibodies (ANA) facilitates the diagnosis of autoimmune diseases (ADs). Here, we report an incidence of ANA positivity and its patterns by indirect immunofluorescence (IIF) and specific autoantibodies through immunodot assay. Methods. Sera from 993 patients presenting with various ADs were tested by IIF and immunodot assay. Results. ANAs were detected in 39.7%, of which speckled pattern was predominantly observed (50.8%). 56.8% of samples were positive on the immunodot assay, with SSA Ro 60 antibody being the most prevalent (30.7%). Discussion. A significant correlation (p < 0.0001) was observed between patterns and auto-antibodies. Coarse speckled (CS) and homogeneous were overly represented by antibodies SSA Ro 60 (13%) and nucleosomes (5.8%), respectively. Mi-2, PL-7, PL-12, and SP-100 were the rarest autoantibodies specificities found. Conclusions. The presence of a particular IIF pattern is predictive of a specific autoantibody in the sample. Association of IIF patterns and specific autoantibody are relevant for a more accurate diagnosis of disease. ADs from 7.5 to 12%, which indicated a significant health care burden (12). Serum antibodies against nucleus and anti-extractable nuclear antigens (ENA) are widely used in clinical practice and are included in the diagnosis of ADs (13,14). The most common autoantibodies are ANAs, which are conventionally assessed by IIF and include antibodies to both nuclear and cytoplasmic components (15). The immunofluorescence staining patterns and specific autoantibodies are clinically relevant as they are associated with particular ADs (16). Due to the ethnic variations, genetic and environmental factors, there is a significant variation in incidence and disease-specific autoantibodies (17,18). Nonetheless, ANA is frequently found in a considerable proportion of healthy subjects although studies are generally performed in selected populations, such as blood donors or employees, while data on ANA prevalence (19-21) and clinical significance over time (22) in an unselected general population, are limited.

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“…The highlighting of ANA in the general population is common and estimated between 5.92 and 30.8% ( 4 – 13 ) with a lower prevalence in the Chinese population ( 4 ) and a higher prevalence in the Afro-American population ( 13 ) (Table 1 ). In addition, ANAs are more commonly detected in women than in men ( 4 – 8 , 10 – 14 ), and the prevalence of such ANA increases with aging, as it reaches up to 24% in subjects older than 85 years ( 14 ). ANAs are commonly detected by indirect immunofluorescence (IIF) on HEp2 cells, a human HELA-derivative cell line.…”

Section: Aab In Healthy Population and In Non-autoimmune Diseasesmentioning

confidence: 99%

Autoantibodies Associated With Connective Tissue Diseases: What Meaning for Clinicians?

Didier¹,

et al. 2018

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Connective tissue diseases (CTDs) such as systemic lupus erythematosus, systemic sclerosis, myositis, Sjögren’s syndrome, and rheumatoid arthritis are systemic diseases which are often associated with a challenge in diagnosis. Autoantibodies (AAbs) can be detected in these diseases and help clinicians in their diagnosis. Actually, pathophysiology of these diseases is associated with the presence of antinuclear antibodies. In the last decades, many new antibodies were discovered, but their implication in pathogenesis of CTDs remains unclear. Furthermore, the classification of these AAbs is nowadays misused, as their targets can be localized outside of the nuclear compartment. Interestingly, in most cases, each antibody is associated with a specific phenotype in CTDs and therefore help in better defining either the disease subtypes or diseases activity and outcome. Because of recent progresses in their detection and in the comprehension of their pathogenesis implication in CTD-associated antibodies, clinicians should pay attention to the presence of these different AAbs to improve patient’s management. In this review, we propose to focus on the different phenotypes and features associated with each autoantibody used in clinical practice in those CTDs.

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The initial manifestations and final diagnosis of patients with high and low titers of antinuclear antibodies after 6 months of follow-up

Abstract: A high ANA titer seems to be a useful biomarker for the diagnosis of autoimmune diseases, especially for patients presenting with joint pain, fever, abnormal urinalysis, or skin rash/skin tightness.

Cited by 24 publications

References 20 publications

The Prevalence of Antinuclear Antibodies in the General Population of China: A Cross-Sectional Study

The Prevalence of Antinuclear Antibodies in the General Population of China: A Cross-Sectional Study

The incidence of immunofluorescence patterns and specific autoantibodies observed in autoimmune patients in a tertiary care centre

Autoantibodies Associated With Connective Tissue Diseases: What Meaning for Clinicians?

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