The Initial Oral Microbiota of Neonates Among Subjects With Gestational Diabetes Mellitus

He, Zhihai; Wu, Jiaman; Xiao, Bin; Xiao, Shanqiu; Li, Hongping; Wu, Keyue

doi:10.3389/fped.2019.00513

Cited by 19 publications

(38 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the new host-microbe homeostasis reshaped by short-term lincomycin administration does seem unfriendly to gut health. Genus Agathobacter can utilize acetate as a substrate to produce butyrate [26,27] and genus Lactobacillus produces numerous advantageous organic acids that can be converted into butyrate [53], which have bene cial effects on the host. Our results displayed that the attenuation of these two bene cial bacteria was observed in the whole experimental time.…”

Section: Discussionmentioning

confidence: 99%

Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine

Tang

Zhang

Zhong

et al. 2021

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Background: Increasing evidence suggests that antibiotic administration causes gut injury, nutrient digestion, immune regulation, and colonization resistance against pathogens due to the disruption of gut microbiota. However, the time-course effects of therapeutic antibiotics on alterations of gut microbes and short-chain fatty acid in young swine are still unknown. In this study, twenty piglets were assigned into two groups and fed commercial diets with or without lincomycin in the rst week for a 28-day trial period.Results: Data showed that one-week lincomycin exposure did reduce the body weight on day 14 (p = 0.0450) and 28 (p = 0.0362). The alpha-diversity notably reduced after one-week lincomycin treatment, then gradually raised and reached the control group level in the second week on cessation of lincomycin exposure, indicated by the variation of Sobs, Chao, Shannon, and ACE index (p < 0.05). Beta-diversity analysis revealed that the distinct microbial cluster existed persistently for the whole trial period between two groups (p < 0.001). The relative abundance of most microbes including ber-degrading (e.g., Agathobacter, Coprococcus, etc.), bene cial (e.g., Lactobacillus, Mitsuokella, etc.), or pathogenic bacteria (e.g., Terrisporobacter, Lachnoclostridium, etc.) decreased and the concentration of short-chain fatty acids also diminished in the feces of one-week lincomycin-administrated young swine (LDA score > 3).After the lincomycin administration stopped, the state of gut dysbiosis gradually recovered and formed new gut-microbe homeostasis distinct from microbial homeostasis of young pigs unexposed to lincomycin. The increased presence of potential pathogens, such as Terrisporobacter, Negativibacillus, Escherichia-Shigella, etc. and decreased bene cial bacteria such as Lactobacillus, Agathobacter were observed in new homeostasis reshaped by short-lincomycin administration (LDA score > 3 or p < 0.05), adversely affecting gut development and health of young pigs. Conclusion:Collectively, these results suggested that severe disruption of the commensal microbiota occurred after short-term lincomycin exposure or termination of lincomycin exposure in young swine. Our study depicts the change rule of gut microbiota in young animals under the condition of short-term lincomycin treatment, providing basic data for evaluating the harmful impact on gut microbe of young animals.

show abstract

Section: Discussionmentioning

confidence: 99%

Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine

Tang

Zhang

Zhong

et al. 2021

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

“…In recent years, research has increasingly shown that GDM altered the gut microbiota composition in the offspring [ 6 – 9 ]. However, the influences of GDM on the oral microbiota of the offspring were less studied [ 10 , 11 ]. He et al [ 11 ] found a distinct oral microbiota profile in neonates born to mothers with GDM.…”

Section: Introductionmentioning

confidence: 99%

Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old

Song

Xiao

Huang

et al. 2022

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

Background Maternal gestational diabetes mellitus (GDM) had long-term influences on the health of their children. However, the influences of GDM on the oral microbiota, which was closely related to oral and systemic health in offspring, were less documented. The present study aimed to explore the oral microbiota of neonates born to mothers with GDM is differentially colonized compared with those born to mothers without GDM, and whether any such differences persist to 1 month of age. Methods Oral samples were collected from children of mothers with (n = 20) and without GDM (n = 34) at birth and again at an average age of 1 month. The oral microbiota was characterized by 16S rRNA sequencing (V3-V4). Differences in diversity and composition according to maternal GDM status were assessed, and different metabolic functional pathways and microbial ecological networks were also analyzed. Results Although no significant differences were observed in diversity metrics between GDM and non-GDM groups (P > 0.05), we found significant differences in the taxonomic composition of oral microbiota from phylum to genus level between the two groups, with the GDM group exhibiting less abundance of Veillonella in both “Day 1” (P < 0.001) and “Day 30” (P < 0.05) phases. Metabolic pathways analysis showed that 5-aminoimidazole ribonucleotide biosynthesis and inosine-5'-phosphate biosynthesis were enriched in GDM subjects in the “Day 30” phase. Moreover, ecological network analysis revealed apparent differences between GDM and control groups, with the non-GDM group containing more high-degree nodes and microbial interactions compared with the GDM group. Conclusion Maternal GDM was associated with an altered oral microbial composition in neonates, although the distinct difference between GDM and non-GDM groups diminished in infancy. The oral microbiota functions and ecological networks differed dramatically between the two groups, highlighting the importance of maternal GDM status on initial oral microbiota in offspring.

show abstract

“…Our results were in concordance with the results obtained by He et al ., who also reported similar findings. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…Lipopolysaccharides are a significant component of cell wall of Gram-negative bacteria, and it plays a substantial pathogenetic role of certain bacterial infections. [ 8 ] Its enhancement in GDM patients may have significant effects on the health of neonates, and hence further exploration of results with higher parameters is necessary.…”

Section: Discussionmentioning

confidence: 99%

“…The exclusion criteria were mothers without preeclampsia, eclampsia, pregnancy-induced hypertension (PIH), maternal obesity and infections, and patients with a negative history of any antibiotic therapy in the past 1 month. [ 8 ] All patients were well informed regarding the study and their consent was taken. Data such as name, age of mother, gestational age, birth weight (grams), prepregnancy body mass index (BMI), and antepartum BMI were recorded.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of effect of gestational diabetes mellitus on composition of the initial oral microbiota of neonates

et al. 2020

View full text Add to dashboard Cite

Background: Gestational diabetes mellitus (GDM) is one of the commonly occurring high-risk obstetric complications that accounts for 4%–9% of total pregnancies. The present study was an attempt to assess the effect of GDM on composition of the neonatal oral microbiota. Materials and Methods: In this study, oral samples from 155 full-term vaginally delivered newborns were collected with sterile swabs. Seventy-five mothers diagnosed with GDM group and 80 were nondiabetic mothers (control). The oral microbiota was evaluated and analyzed by SPSS software. Results: The mean gestational age in Group I was 38.1 weeks and in Group II was 39.6 weeks. Firmicutes was present in 38.1% in Group I versus 77.6% in Group II patients, Actinobacteria was seen in 15.2% in Group I and 7.4% in Group II, Bacteroidetes in 27.6% in Group I and 7.9% in Group II, Proteobacteria in 9.5% in Group I and 3.8% in Group II, and Tenericutes in 9.6% in Group I and 3.3% in Group II. There was a significant difference in major genera Prevotella , Bacteroidetes , Bifidobacterium , Corynebacterium , Ureaplasma, and Weissella in both groups ( P < 0.05). Conclusion: There was increased bacterial microbiota in neonates born to mothers with GDM as compared to neonates born to nondiabetic mothers. Assessment of initial oral microbiota of neonates could help in assessing the early effect of GDM on neonatal oral microbial flora.

show abstract

The Initial Oral Microbiota of Neonates Among Subjects With Gestational Diabetes Mellitus

Cited by 19 publications

References 43 publications

Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine

Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine

Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old

Evaluation of effect of gestational diabetes mellitus on composition of the initial oral microbiota of neonates

Contact Info

Product

Resources

About