The Innate Immune Response and Activation of Coagulation in . 1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients

Ezzelarab, Mohamed; Lin, Chin Chuen; Hara, Hideyuki; Ayares, D; Dorling, Anthony; Cooper, D. K. C.

doi:10.1097/01.tp.0000332754.63678.29

Cited by 22 publications

(34 citation statements)

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“…Xenogeneic activation also prompts neutrophils to secrete proinflammatory cytokines, such as IL-1a/b, IL-6, and IL-8, involved in cellular and humoral adaptive immune responses and platelet activation, crucial players in the rejection process. As shown in some studies, polymorphonuclear neutrophils appear to (Kirchhof et al 2004;Hisashi et al 2008;Ezzelarab et al 2009;Shimizu et al 2012). As shown in the majority of reports, however, this infiltration appears to be replaced by T cells and macrophages (Kirchhof et al 2004;Hisashi et al 2008;Ezzelarab et al 2009;Shimizu et al 2012 Sommaggio et al 2012).…”

Section: The Role Of the Cells Involved In The Innate Immune Responsementioning

confidence: 96%

“…As shown in some studies, polymorphonuclear neutrophils appear to (Kirchhof et al 2004;Hisashi et al 2008;Ezzelarab et al 2009;Shimizu et al 2012). As shown in the majority of reports, however, this infiltration appears to be replaced by T cells and macrophages (Kirchhof et al 2004;Hisashi et al 2008;Ezzelarab et al 2009;Shimizu et al 2012 Sommaggio et al 2012). The direct cytotoxic activity of NK cells, which is inhibited primarily by human MHC class I molecules through inhibitory NK receptors, is not blocked by SLA class I products.…”

Section: The Role Of the Cells Involved In The Innate Immune Responsementioning

confidence: 96%

“…The introduction of anti-CD154 monoclonal antibodies has contributed to a significantly longer solidorgan and islet xenograft survival (Kuwaki et al 2005;Yamada et al 2005;Cardona et al 2006;Hering et al 2006), while preventing elicited antibody responses ). These results have been severely penalized by thromboembolic events that have precluded further use of anti-CD154 antibodies and prompted researchers to explore other therapeutic options, such as anti-CD40 agents or CTLA4Ig-based strategies in combination with immunosuppressive drugs (Ezzelarab et al 2009;Thompson et al 2011b). Using an anti-CD40 antibody associated with belatacept extended neonatal porcine islet survival (Thompson et al 2011b), although further studies are needed to confirm this finding.…”

Section: Systemic Immunosuppressionmentioning

confidence: 98%

“…Third, NK cells rapidly infiltrate porcine xenografts perfused ex vivo with human blood (Kirk et al 1993;Inverardi and Pardi 1994). In explanted xenografts, on the other hand, NK cells were found in small numbers (Davila et al 2006;Hisashi et al 2008;Shimizu et al 2012) or were not reported (Ashton-Chess et al 2003;Cozzi et al 2003;McGregor et al 2005;Ezzelarab et al 2009), except for one case in which the particular features of the model may have heavily influenced the outcome (Itescu et al 1998). It is worth noting, however, that the in vivo studies conducted to date cannot definitely rule out the possibility of NK cells being directly implicated in the untimely failure of xenografts.…”

Section: The Role Of the Cells Involved In The Innate Immune Responsementioning

confidence: 99%

“…They appear to have a pivotal role in cellular graft rejection, and they have also been identified soon after solid organ xenografting. They continue to be detectable up until the graft is rejected (Ashton-Chess et al 2003;Cozzi et al 2003;Hisashi et al 2008;Ezzelarab et al 2009;Shimizu et al 2012), and they have been accused of contributing to the onset of graft failure and TM (Ezzelarab et al 2009). …”

Section: The Role Of the Cells Involved In The Innate Immune Responsementioning

confidence: 99%

See 4 more Smart Citations

Immunological Challenges and Therapies in Xenotransplantation

Vadori

2014

Cold Spring Harbor Perspectives in Medicine

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Section: The Role Of the Cells Involved In The Innate Immune Responsementioning

confidence: 96%

Section: The Role Of the Cells Involved In The Innate Immune Responsementioning

confidence: 96%

Section: Systemic Immunosuppressionmentioning

confidence: 98%

Section: The Role Of the Cells Involved In The Innate Immune Responsementioning

confidence: 99%

Section: The Role Of the Cells Involved In The Innate Immune Responsementioning

confidence: 99%

See 3 more Smart Citations

Immunological Challenges and Therapies in Xenotransplantation

Vadori

2014

Cold Spring Harbor Perspectives in Medicine

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Organ Transplantation in Times of Donor Shortage

Jox¹,

Assadi²,

Marckmann³

2016

International Library of Ethics, Law, and the New Medicine

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The book series International Library of Ethics, Law and the New Medicine comprises volumes with an international and interdisciplinary focus. The aim of the Series is to publish books on foundational issues in (bio) ethics, law, international health care and medicine. The 28 volumes that have already appeared in this series address aspects of aging, mental health, AIDS, preventive medicine, bioethics and many other current topics.This Series was conceived against the background of increasing globalization and interdependency of the world's cultures and governments, with mutual influencing occurring throughout the world in all fields, most surely in health care and its delivery. By means of this Series we aim to contribute and cooperate to meet the challenge of our time: how to aim human technology to good human ends, how to deal with changed values in the areas of religion, society, culture and the self-definition of human persons, and how to formulate a new way of thinking, a new ethic.We welcome book proposals representing the broad interest of the interdisciplinary and international focus of the series. We especially welcome proposals that address aspects of 'new medicine', meaning advances in research and clinical health care, with an emphasis on those interventions and alterations that force us to reexamine foundational issues.More information about this series at

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A solid-phase screening method for identification of glycan-binding cells

Kim

Hwang

et al. 2015

Biotechnol Bioproc E

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Glycan immobilization and epitope recognition on a solid support is useful for functional glycoproteomics and analysis of protein-protein interactions. However, the lack of high-throughput experimental methods for the examination of cell-glycan interactions means that identifying glycan-binding cells remains a challenge. Herein, we describe a tool which enables the screening of glycanbinding cells that specifically recognize the glycan epitopes released from the membrane glycoproteins of cells and tissues. Biotinylated pig kidney N-glycans were immobilized on streptavidin-conjugated solid supports and then incubated with human immune cell lines. U937 cells discriminated between the α-galactose (α-Gal) and non-Gal pig Nglycans on the solid support. This screening strategy could aid exploration of cell-protein or cell-cell interactions.

show abstract

The Innate Immune Response and Activation of Coagulation in . 1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients

Cited by 22 publications

References 0 publications

Immunological Challenges and Therapies in Xenotransplantation

Immunological Challenges and Therapies in Xenotransplantation

Organ Transplantation in Times of Donor Shortage

A solid-phase screening method for identification of glycan-binding cells

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