Purpose. Development of a methodological approach to the assessment of the enterprise innovation strategy and its modeling. Methodology. During the research, we used general and special methods: systematization for generalization of theoretical bases, comparative analysis and synthesis in order to clarify concepts, formal-logistical for the formation of a methodological approach, graphic-analytical method for visual presentation of research results; empirical research for the study of innovation potential, simulation and multiple regression modeling for the formation of strategic guidelines. Findings. The methodical approach of assessment of the enterprises innovative potential was grounded and the initiative model of choosing the strategy of enterprises was created, which allows analyzing quantitative indicators of structural elements of potential, assessing the level of development of each component. In the course of the research a methodical approach to assessing the intellectual potential of industrial enterprises has been developed. Originality. In contrast to the existing ones, this methodological approach provides: a comprehensive assessment of the innovation potential of industrial enterprises; econometric models for determining the components of the innovation potential of enterprises; the model of innovation strategy selection, which is an informational and analytical tool for working out the variants of strategies and development orients. It is proved that the implementation of the developed methodological approach will allow adopting an effective innovative strategy of enterprise development taking into account financial and economic narratives. Practical value. The results of the research can be used by practitioners, scientists, government officials (the Ministry of Economic Development and its structural divisions, local self-government bodies in the field of economics) for the development and implementation of innovation strategies, as well as for the development of managerial decisions in the field of innovation, increasing the value added, capitalization and level of competitiveness.