“…51,52 The following criteria are typically taken into consideration for the determination of exogenous mediators: (i) widely accessible or simply producible via electrochemistry, (ii) electropositive enough to reduce NAD(P)H directly for effective energy transfer to cellular metabolism, and (iii) highly soluble in aquatic solution and non-highly toxic. 53 As increasingly sophisticated extracellular electron transfer mechanisms are investigated in the biotechnology application of electromicrobiology, 54,55 the e-BNF routes provide an alternative avenue to synthesize ammonia. Compared to other approaches, e-BNF empowers unique merits of potentially sustainable, widespread scopes of the feed substrates, ambient reaction conditions, high selectivity, and high energy efficiency.…”