The insect SNMP gene family

Vogt, Richard G.; Miller, Natalie E.; Litvack, Rachel; Fandino, Richard A.; Sparks, Jackson T.; Staples, Jon; Friedman, Robert M.; Dickens, Joseph C.

doi:10.1016/j.ibmb.2009.03.007

Cited by 240 publications

(235 citation statements)

References 41 publications

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“…5B ). As shown in previous studies ( 39,40 ), the insect proteins could be divided into three groups, while mammalian proteins formed a single, distinct group. SCRB15 and Cameo2 were somewhat removed from each other and fell into groups 1 and 2 , respectively.…”

Section: Expression Analysis Of Cameo2 Paralogs Near the F Locussupporting

confidence: 55%

“…Numbers at nodes indicate the percentage of bootstrap values of 10,000 replicates. Groups are based on previous reports ( 39,40 ). Although 21 homologs were found in the gene database of Danaus plexippus ( 38 ), only 11 of those more than 368 amino acids long were included in this tree; the other 10 homologs were shorter than 288 amino acids.…”

Section: Expression Analysis Of Cameo2 Paralogs Near the F Locusmentioning

confidence: 99%

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CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori

Sakudoh

Kuwazaki²,

Iizuka

et al. 2013

Journal of Lipid Research

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Section: Expression Analysis Of Cameo2 Paralogs Near the F Locussupporting

confidence: 55%

Section: Expression Analysis Of Cameo2 Paralogs Near the F Locusmentioning

confidence: 99%

CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori

Sakudoh

Kuwazaki²,

Iizuka

et al. 2013

Journal of Lipid Research

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“…The TBLASTN program was used to search for all genes homologous to Cameo1 and Cameo2 in the silkworm genome sequence (22) and EST data base (23) with a cutoff E value of 5 ϫ 10 Ϫ3 and the results did not include any others besides these 13 genes. One of these homologous genes, SNMP1, has been cloned (24), and recently 10 of them were reported and named by independent data base searches (25,26). We use in this paper the same names for the total 11 genes and term the other two genes, BGIBMGA13436 and BGIBMGA13438 in the China gene model ("BGIBMGA" is a prefix for gene name), SCRB14 and SCRB15, respectively.…”

Section: Methodsmentioning

confidence: 99%

A CD36-related Transmembrane Protein Is Coordinated with an Intracellular Lipid-binding Protein in Selective Carotenoid Transport for Cocoon Coloration

Sakudoh

Iizuka

Narukawa

et al. 2010

Journal of Biological Chemistry

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The transport pathway of specific dietary carotenoids from the midgut lumen to the silk gland in the silkworm, Bombyx mori, is a model system for selective carotenoid transport because several genetic mutants with defects in parts of this pathway have been identified that manifest altered cocoon pigmentation. In the wild-type silkworm, which has both genes, Yellow blood (Y) and Yellow cocoon (C), lutein is transferred selectively from the hemolymph lipoprotein to the silk gland cells where it is accumulated into the cocoon. The Y gene encodes an intracellular carotenoid-binding protein (CBP) containing a lipid-binding domain known as the steroidogenic acute regulatory protein-related lipid transfer domain. Positional cloning and transgenic rescue experiments revealed that the C gene encodes Cameo2, a transmembrane protein gene belonging to the CD36 family genes, some of which, such as the mammalian SR-BI and the fruit fly ninaD, are reported as lipoprotein receptors or implicated in carotenoid transport for visual system. In C mutant larvae, Cameo2 expression was strongly repressed in the silk gland in a specific manner, resulting in colorless silk glands and white cocoons. The developmental profile of Cameo2 expression, CBP expression, and lutein pigmentation in the silk gland of the yellow cocoon strain were correlated. We hypothesize that selective delivery of lutein to specific tissue requires the combination of two components: 1) CBP as a carotenoid transporter in cytosol and 2) Cameo2 as a transmembrane receptor on the surface of the cells.All organisms exposed to light contain carotenoids, which are yellow to red C 40 hydrophobic isoprenoid pigments. Carotenoids play pivotal roles in living organisms as precursors of vitamin A, antioxidants, and colorants (1). Their potential roles in medicine have recently been investigated. For example, macular accumulation of the carotenoids lutein and zeaxanthin is associated with a decreased risk of age-related macular degeneration (2), the leading cause of blindness in the developed world. Although plants, certain fungi, and bacteria synthesize carotenoids, animals appear to be incapable of synthesizing these molecules de novo. Therefore, animals must acquire carotenoids from dietary sources, and subsequently transport them to cells of target tissues.The delivery of lipids, including carotenoids, to cells can be divided into three categories: 1) enzyme-mediated processes, such as the action of lipoprotein lipase on very low density lipoproteins, which converts a lipoprotein-bound lipid, triacylglycerol, into a water-soluble product, fatty acid, which diffuses into cells and leaves behind in the blood a lipoprotein product depleted in triacylglycerol (3); 2) receptor-mediated endocytosis, such as the uptake of low density lipoproteins by low density lipoprotein receptor, in which the entire lipoprotein particle is taken into the cell and metabolized (4); and 3) the delivery of specific lipids to specific tissues devoid of lipoprotein degradation, called selective lip...

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“…S3), showing that SNMP2 transcripts were enriched in legs. By contrast, transcripts of SNMP1 paralogs (SNMP1a, SNMP1b, and SNMP1c) (18,25) were all highly enriched in antennae, although the precise role(s) of SNMPs in mosquito olfaction is (are) yet to be elucidated.…”

Section: Odorant-binding Proteins Highly Expressed In Antennae and Legsmentioning

confidence: 99%

Differential expression of olfactory genes in the southern house mosquito and insights into unique odorant receptor gene isoforms

Leal

Choo

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

102

100

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The southern house mosquito, Culex quinquefasciatus, has one of the most acute and eclectic olfactory systems of all mosquito species hitherto studied. Here, we used Illumina sequencing to identify olfactory genes expressed predominantly in antenna, mosquito's main olfactory organ. Less than 50% of the trimmed reads generated by high-quality libraries aligned to a transcript, but approximately 70% of them aligned to the genome. Differential expression analysis, which was validated by quantitative realtime PCR on a subset of genes, showed that approximately half of the 48 odorant-binding protein genes were enriched in antennae, with the other half being predominantly expressed in legs. Similar patterns were observed with chemosensory proteins, "plus-C" odorant-binding proteins, and sensory neuron membrane proteins. Transcripts for as many as 43 ionotropic receptors were enriched in female antennae, thus making the ionotropic receptor family the largest of antennae-rich olfactory genes, second only to odorant receptor (OR) genes. As many as 177 OR genes have been identified, including 36 unique transcripts. The unique OR genes differed from previously annotated ORs in internal sequences, splice variants, and extended N or C terminus. One of the previously unknown transcripts was validated by cloning and functional expression. When challenged with a large panel of physiologically relevant compounds, CquiOR95b responded in a dose-dependent manner to ethyl 2-phenylacteate, which was demonstrated to repel Culex mosquitoes, and secondarily to citronellal, a known insect repellent. This transcriptome study led to identification of key molecular components and a repellent for the southern house mosquito.RNA-Seq | citronellal polymorphism isoforms

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The insect SNMP gene family

Cited by 240 publications

References 41 publications

CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori

CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori

A CD36-related Transmembrane Protein Is Coordinated with an Intracellular Lipid-binding Protein in Selective Carotenoid Transport for Cocoon Coloration

Differential expression of olfactory genes in the southern house mosquito and insights into unique odorant receptor gene isoforms

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