The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases

Conway, Simon J.; Doetschman, Thomas; Azhar, Mohamad

doi:10.1100/tsw.2011.132

Cited by 57 publications

(41 citation statements)

References 128 publications

(195 reference statements)

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“…The increase in the expression of POSTN in CRS, with and without polyps, tissue is not surprising because POSTN plays multiple potential roles in epithelial structure and immune regulation. Several lines of evidence have suggested the importance of this matricellular protein in accelerating lung inflammation by enhancing chemokine production in fibroblasts, eosinophil recruitment, or TGF-beta activation in airway epithelial cells (Wen et al, 2010;Conway et al, 2011). What turned out to be more interesting in our analysis was that POSTN expression was greater in CRSwNP than CRSsNP, and especially that similar results were obtained by Zhang et al in previous studies (Zhang et al, 2012).…”

Section: Discussionsupporting

confidence: 86%

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Miłoński

Zielińska‐Bliźniewska

Majsterek

et al. 2015

DNA and Cell Biology

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most frequently encountered chronic nasal diseases with a significant impact on patient quality of life. The aim of our study was therefore to investigate the association between the POSTN, IL-4, and IL-13 gene expression and the nasal polyp development. The objective of this study was to determine differential expression of POSTN, IL-4, and IL-13 genes in the mucosa and polyps of 63 patients with CRSwNP and 23 chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) when compared with patients with nasal septum deviation (n=18) who were used as controls. The expression level was investigated using reverse transcription-polymerase chain reaction assays in the polyp tissue and the mucosa of paranasal sinus collected while undergoing functional endoscopic sinus surgery. Expression of the mRNAs of all three genes, IL-4, IL-13, and POSTN, was significantly greater in the paired tissues of CRS patients with NPs or without NPs than in control subjects, with highest levels of POSTN and IL-13 seen in CRSwNP. An increased level of POSTN, IL-4, and IL-13 gene expression may be related to the development of chronic rhinosinusitis with nasal polyps, but polyp formation seemed to be associated especially with POSTN and IL-13 expression.

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Section: Discussionsupporting

confidence: 86%

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Miłoński

Zielińska‐Bliźniewska

Majsterek

et al. 2015

DNA and Cell Biology

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“…Importantly, excess accumulation of collagen in both ascending and descending aortic tissues of Fbn1 +/C1039G mice, as seen by us and others, is speculated to be able to interfere with collagen fiber orientation and alignment. Other workers have shown that exogenously added TGFβ1 increases the levels of periostin, which is required for collagen assembly and organization (Snider et al 2008;Conway et al 2011). The exact role of TGFβ1 and other TGFβ ligands (i.e., TGFβ2, TGFβ3) in collagen organization in vivo in the aortic tissue of Fbn1 +/C1039G mice remains to be studied.…”

Section: Discussionmentioning

confidence: 97%

Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome

et al. 2011

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Aortic aneurysm is predominantly found in the ascending aorta in patients with Marfan syndrome (MFS). However, descending aortic disease has emerged as a problem since people are living longer because of improved medical and surgical management of the ascending aorta. Diagnostic procedures before disease onset and the mechanisms involved in the transition of normal aortic tissue to aneurysm remain unclear. We determined signs of descending aortic disease before disease onset in mice with a mutation in the fibrillin 1 gene (Fbn1(+/C1039G)), a validated mouse model of disease susceptibility and progression of aortic aneurysm of MFS. We analyzed a tubular unfixed non-aneurysmal descending thoracic aorta from 8-month-old wild-type and Fbn1(+/C1039G) mice by a tubular biaxial tester that works in conjunction with a two-photon nonlinear microscope. Fbn1(+/C1039G) mouse aorta was more compliant in the circumferential direction. Two-photon imaging showed defective organization of adventitial collagen fibers in the pressurized aortas of Fbn1(+/C1039G) mice. Moreover, disruption in the elastic lamina was noted in the absence of aneurysms in pressurized aortas but not unpressurized aortas of Fbn1(+/C1039G) mice. At the molecular level, this altered tissue behavior in non-aneurysmal descending aortas of Fbn1(+/C1039G) mice was accompanied by an increasing trend of canonical but not noncanonical, transforming growth factor-β (TGFβ) signaling. Finally, assays of in vitro collagen lattice formation in mouse wild-type and TGFβ1-deficient embryonic fibroblasts indicate that TGFβ1 can regulate collagen organization. The ability to reveal the presence of altered biomechanics and microstructure coupled with subtle changes in TGFβ signaling provides a novel surrogate measure of tissue susceptibility to aneurysm before disease onset.

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“…Similarly to TGF-β, BMPs have been investigated during development and emerged as key factors in heart valve formation and morphogenesis [30,31]. BMP4 is important for the local proliferation and migration of cardiac neural crest cells and so for outflow tract valve development [32,33].…”

Section: Bone Morphogenetic Proteinsmentioning

confidence: 99%

Emerging pathogenic mechanisms in human myxomatous mitral valve: lessons from past and novel data

Hulin

Deroanne

Lambert

et al. 2013

Cardiovascular Pathology

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The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases

Cited by 57 publications

References 128 publications

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome

Emerging pathogenic mechanisms in human myxomatous mitral valve: lessons from past and novel data

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