The interaction effects of resistance training and sustanon abuse on liver antioxidant activities and serum enzymes in male rats

Abstract

BackgroundAnabolic–androgenic steroids (AAS) are synthetic drugs derived from testosterone, the uncontrolled usage of which may lead to serious side effects. Previous studies have shown that resistance training (RT) is the main exercise modality practiced by AAS abusers. Thus, this work was carried out to evaluate the hepatotoxic effects of sustanon (Su) as an example of AAS in trained male rats.MethodsRats were divided into sedentary/non-Su, sedentary/Su, RT/non-Su, and RT/Su. Su-administration groups received Su 10 mg/kg intramuscularly once a week for 8 weeks. In the 8-week RT, the rats climbed a vertical ladder 3 days/week.ResultsAfter Su administration, the mean values of serum parameters related to hepatic function were within normal ranges. Superoxide dismutase, glutathione peroxidase, and glutathione reductase activities were higher (P < 0.05) in the liver of Su-treated rats. Chronic exercise alone did not change any of the above parameters.ConclusionsThe present findings suggest that the 8-week injection of Su, either with or without concurrent RT upregulation of enzymatic antioxidant activities and RT, did not attenuate the increase of enzymatic activities due to the Su administration. Furthermore, Su abuse in this dose did not make any severe liver damage.

The Effect of Resistance Training with Tribulus terrestris on Liver Enzymes in Rats Exposed to Stanozolol

“…Considering these values during 8 weeks of resistance training and consumption of Sustanon, a significant decrease was observed in oxidative markers; however, no significant change was observed in liver enzymes. 23 The difference in the results of these two studies can be attributed to the differences in the type of steroid, so as mentioned before, liver enzymes exposed to stanozolol are in the front line of change and damage. 4 The results showed that TT consumption at doses of 50 and 100 mg/kg reduced AST, ALT, and ALP levels in rats exposed to stanozolol.…”

Neurosteroid, Natural and Anabolic Steroids: Physiological, Immunological and Histopathological Study on Diabetic Albino Rats

“…Also, Werumeus et al [51], reported a reduction in ALP activity in response to high dose of hydrocortisone. Testosterone treatment dropped the ALP activity in both genders of the treated rats, which could be explained as the base of alterations of bone turnover due to high dose of testosterone [16,52].…”

“…It releases testosterone continuously into the blood and maintains a stable testosterone level for a long time, lasting for three to four weeks. It has been supported by several of lines of evidence that testosterone therapy reduces insulin resistance [15,16].…”

Neurosteroid, Natural And Anabolic Steroids: Physiological, Immunological And Histopathological Study on Hyperlipidaemic Albino Rats

“…Sustanon releases testosterone continuously into the blood for a period of three to four weeks, maintaining a constant testosterone level. A number of lines of evidence have shown that testosterone therapy might improve glucose level (Arazi et al, 2017;Gianatti et al, 2014).…”