The interaction of carbaryl with the metabolism of isolated hepatocytes: I. Effect on respiration and glycolysis

Parafita, Manuel A.; Fernandez-Otero, P.; Aldegunde, M.

doi:10.1016/0306-3623(84)90009-0

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Carbaryl causes a reversible block in metaphase, spindle microtubule depolymerization, displacement of chromosomes to the periphery of the cell and, concomitant to this, a remarkable progression of the cytoplasmic changes typical of anaphase and telophase (13,15,33). Though carbaryl is relatively safe to mammals, 10 M and 1mM carbaryl causes damage to hepatocytes (34). Apparently less harmful carbaryl has some serious effects on human, as evidenced by morphologic abnormalities and genotoxic defects of spermatozoa, DNA breakage and chromosomal aberrations (35).…”

Section: Mode Of Actionmentioning

confidence: 99%

Carbaryl and Human Health: A Review

Sahana¹,

Agarwal

2018

JoS

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Carbaryl (1-naphthalenylmethylcarbamate) is one of the most frequently used carbamate insecticides. Carbaryl has elicited some serious carcinogenic activity in the chronic rodent studies and has also been found to cause tumors in the liver. Though carbaryl is relatively safe to mammals, but carbaryl causes damage to hepatocytes. It has other biochemical effects, as it reacts with reduced glutathione and probably directly with other accessible protein hydroxyl and sulphydryl groups or indirectly through reactions involving the glutathione conjugate. In mammals, carbaryl inhibits acetylcholinesterase causing several neural problems. Some recent reports suggest it can bind human melatonin receptors exerting serious implications on human health. Here in this review an attempt has been made to summarise carbaryl’s mode of action and its ill effects on human health.

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Section: Mode Of Actionmentioning

confidence: 99%