The Interaction of Donor and Host Lymphoid Cells in the Pathogenesis of Renal Cortical Destruction Induced by a Local Graft Versus Host Reaction

Abstract

The graft versus host reaction (GVHR), which results from the injection of parental strain spleen cells beneath the kidney capsule of F1 hybrid rats, is transferable during its developmental phase into F1 hybrid hosts isogeneic with the primary host, but not into secondary hosts of the parental (donor) strain. Furthermore, the GVHR propagates but rarely in secondary hybrid hosts which are allogeneic with respect to the primary hosts, but which are also genetically tolerant of donor-type cells. These findings indicate that the donor cells not only initiate the GVHR but also maintain it by virtue of immunologically specific activity. Whole-body irradiation of (LBf)F1 and (LBN)F1 hosts 24 hours prior to the injection of parental (L) spleen cells results in inhibition of the subsequent GVHR to a degree commensurate with the radiation damage sustained by the lymphoid system of the host. Furthermore, propagation of transferred GVHRs did not occur if susceptible secondary hybrid hosts had been previously irradiated. These findings indicate that radiosensitive host cells play a continuing and essential role in the pathogenesis of the invasive-destructive lesion. It is concluded that the development of this lesion depends upon the continuous interaction of the specifically reactive donor-type cells with an immunologically non-specific population of host mononuclears.

A STUDY OF THE PASSIVE TRANSFER OF DELAYED HYPERSENSITIVITY TO DNP-POLY-L-LYSINE AND DNP-GL IN RESPONDER AND NONRESPONDER GUINEA PIGS

“…The importance of host mononuclear cells for the proper expression of passive transfer of delayed sensitivity has been recently emphasized by other authors (15,16). S~&RY A study of the passive transfer of delayed hypersensitivity to DNP-poly-Llysine and to DNP-GL was performed in Hartley guinea pigs.…”

Lymphokines in the rheumatoid joint

“…Cell-mediated immune reactions discharged by lymphocytes of the thymus-dependent variety are known to be required for antibody production to many antigens (12), for resistance to intracellular infection (13) and to the development of neoplasms (14), for the development of the inflammatory processes of delayed hypersensitivity (15), for allograft rejection, and for the graft-versus-host response (16,17). I n each of these functions it appears that T-lymphocytes must be triggered by specific antigen.…”

F₁ Hybrid Animals: Reactivity Against Recognition Structures of Parental Strain Lymphoid Cells

“…Numerous examples of graft-versus-host (GVII) reactivities confirm this [4], Although the ultimate mechanism of these immunological reactions is not well understood, it is certain that they are initiated by parental strain lymphoid cells reacting against antigens foreign to (hem [5]. Sub sequent events have been ascribed to the aggressiveness of these donor cells, although the importance of host factors contributing to lesions of GVH reactions is now appreciated [6][7][8][9][10][11]. This ex planation of events underlying GVH reactivity is, however, lacking one component: The immunological competent donor cell must have cellular structures absent from the F, host and hence foreign to it.…”