The interaction of genotype and exogenous neonatal androgen: Agonistic behavior in female mice

Vale, Jack R.; Ray, Donald; Vale, Carol A.

doi:10.1016/s0091-6773(72)80104-4

Cited by 41 publications

(15 citation statements)

References 41 publications

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“…Subcutaneous injection of TP on PN2 to A strain and BALB/c mice, reduces the number of times adult ovary-intact females receive mounts with an intromission as compared to same strain controls [217]. Like rats, adult hormone replacement does not eliminate long-lasting effects of neonatal androgens.…”

Section: Female Sex Behavior: Receptivity and Lordosismentioning

confidence: 99%

Of mice and rats: Key species variations in the sexual differentiation of brain and behavior

Bonthuis

Cox

Searcy

et al. 2010

Frontiers in Neuroendocrinology

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Mice and rats are important mammalian models in biomedical research. In contrast to other biomedical fields, work on sexual differentiation of brain and behavior has traditionally utilized comparative animal models. As mice are gaining in popularity, it is essential to acknowledge the differences between these two rodents. Here we review neural and behavioral sexual dimorphisms in rats and mice, which highlight species differences and experimental gaps in the literature, that are needed for direct species comparisons. Moving forward, investigators must answer fundamental questions about their chosen organism, and attend to both species and strain differences as they select the optimal animal models for their research questions.

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Section: Female Sex Behavior: Receptivity and Lordosismentioning

confidence: 99%

Of mice and rats: Key species variations in the sexual differentiation of brain and behavior

Bonthuis

Cox

Searcy

et al. 2010

Frontiers in Neuroendocrinology

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“…From studies of mice, it appears that exposure to androgens during the developmental period is an additional essential factor in mammals, without which later physiological levels of androgens are ineffective (Edwards, 1968;Desjardins, 1968, 1970;Conner and Levine, 1969;Edwards and Herndon, 1970). Some important qualifications to these findings are that there is an interaction with the genotype (Vale et al, 1972) and that the critical period for exposure to early hormones is less restricted than was originally supposed (Edwards, 1970).…”

Section: Sex Hormonesmentioning

confidence: 99%

The Organization of Aggression and Fear In Vertebrates

Archer

1976

Perspectives in Ethology

107

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I. ABSTRACTThis chapter considers what factors influence the occurrence of attack and fear behavior (e.g., immobility, flight, distress signals). It is argued that, with the exception of conditioned attack and fear behavior, the same types of basic situations are capable of evoking either type of response.These situations are as follows: (l) Pain. (2) A moving object coming too close to an animal (individual distance intrusion). (3) A novel object or animal entering another's familiar area: this includes not only the typical territorial situation, but also a wide range of other situations. (4) Entrance into an unfamiliar area: most commonly, fear behavior occurs, but attack can occur if there is a suitable target. (5) A familiar object in an unfamiliar place. (6) Frustrative nonreward. (7) Thwarting (a physical object preventing completion of a learned response). (8) Low reinforcement schedules, which involve delayed reward. (9) Morphine withdrawal, which is similar to frustrative nonreward.It is suggested that all these situations can summate with one another, up to a certain limit, to increase the likelihood and intensity of attack, but that above this limit fear behavior occurs.It is then suggested that all the situations involve the common property of a discrepancy between observed and expected stimulation. Different types of "neuronal models" may represent the different types of expect a-

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“…Several studies have examined the role of androgens in the development of aggressive behavior, both organizationally (e.g., prenatal testosterone treatment) and activationally (e.g., postnatal testosterone treatment). Previous research has found that prenatal androgen exposure increases the behavioral expression of adult aggression (Vale et al 1972;Michard-Vanhee 1988). Although organizational and activational influences of androgen on aggression have been noted, some inconsistent results have been reported.…”

Section: Neurotransmitter Interactionsmentioning

confidence: 97%

Sex, Drugs, and Violence: Neuromodulation of Attachment and Conflict in Voles

Gobrogge

2013

Neuroscience of Aggression

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Prairie voles (Microtus ochrogaster) are a rodent species that display socially monogamous pair-bonds, a behavior illustrated by several types of social interactions such as mating-induced partner preference, selective aggression toward conspecific strangers, and bi-parental care. Therefore, this species has provided an excellent opportunity for the study of pair-bonding and its underlying neurochemical mechanisms. This chapter discusses the utility of this unique rodent in the study of attachment and conflict, and reviews recent findings illustrating the neuromodulatory mechanisms underlying mating-induced partner preference and aggression. Finally, implications of research using this animal model in human mental health are also discussed.

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The interaction of genotype and exogenous neonatal androgen: Agonistic behavior in female mice

Cited by 41 publications

References 41 publications

Of mice and rats: Key species variations in the sexual differentiation of brain and behavior

Of mice and rats: Key species variations in the sexual differentiation of brain and behavior

The Organization of Aggression and Fear In Vertebrates

Sex, Drugs, and Violence: Neuromodulation of Attachment and Conflict in Voles

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