The interaction of sodium trimetaphosphate with collagen I induces conformational change and mineralization that prevents collagenase proteolytic attack

Carvalho, Rafael Guzella de; Alvarez, Marcela Maciel Palacio; Oliveira, Thales de Sá; Polassi, Mackeler Ramos; Vilhena, Fabiano Vieira; Alves, Flávio Lopes; Nakaie, Clóvis R.; Nascimento, Fábio D.; D’Alpino, Paulo Henrique Perlatti; Tersariol, Ivarne L.S.

doi:10.1016/j.dental.2020.03.023

Cited by 9 publications

(9 citation statements)

References 45 publications

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“…is could influence the binding mechanism of tannins to collagen fibrils and their potential stabilization mechanism [3]. In spite of these limitations, these results provided important new information regarding the application of these plant extracts previously to the adhesive bonding.…”

Section: Discussionmentioning

confidence: 96%

“…is helps explain their slower ability to diffuse in the collagen matrix, explaining the lesser influence on the elastic modulus and resistance to degradation when applied for 1 minute [23]. It has been also claimed that changes in the elastic modulus induced by the plant extracts should be associated with its ability to nucleate calcium and phosphate to form amorphous calcium phosphate crystals to remineralize the exposed uninfiltrated collagen [3]. us, it can be speculated that the true biomodifying action of the extracts after treatment of the dentin fragments should be evaluated after immersion in a saturated solution of calcium and phosphate (Ca/P ratio � 1.67) [3].…”

Section: Discussionmentioning

confidence: 99%

“…It has been also claimed that changes in the elastic modulus induced by the plant extracts should be associated with its ability to nucleate calcium and phosphate to form amorphous calcium phosphate crystals to remineralize the exposed uninfiltrated collagen [3]. us, it can be speculated that the true biomodifying action of the extracts after treatment of the dentin fragments should be evaluated after immersion in a saturated solution of calcium and phosphate (Ca/P ratio � 1.67) [3]. is fact can be corroborated by the "late" biomodifying action of galla chinensis, which induced an increased elastic modulus after immersion in calciumcontaining artificial saliva.…”

Section: Discussionmentioning

confidence: 99%

“…In a certain way, the dentin wettability after treatment with the plant extracts, which would improve the permeation of the adhesive system and the longevity of the adhesive interfaces, needs to be further confirmed to certify the action of these biomodifying agents. At a molecular level, the intermolecular spaces between the collagen fibrils are preserved by the water surrounding the triple helices of the collagen molecules [3]. Consequently, hydrogen bridges are formed preventing direct contact between chains, thus avoiding collagen collapse [41].…”

Section: Discussionmentioning

confidence: 99%

“…e main goal in the bonding of adhesive restorations to dentin is to obtain complete infiltration of the resin monomers into the previously demineralized dentin surface to avoid the degradation of this interfacial area [2]. In this manner, the extent to which the adhesive resin envelops collagen fibrils helps improve the durability of bonding to dentin [3]. Exposed unprotected collagen fibrils after the bonding procedure is regarded to be the main problem that impacts the restoration longevity due to the deterioration that occurs at the hybrid layer [4].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Dentin Priming with Tannin-Rich Plant Extracts on the Longevity of Bonded Composite Restorations

Polassi

Oliveira

Carvalho

et al. 2021

The Scientific World Journal

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Objective. This in vitro study evaluated the influence of bioactive plant extracts as dentin biomodifying agents to improve the longevity of bonded restorations. For that, plant extracts were applied to the dentin surface prior to the adhesive system. Materials and Methods. Bovine incisors were ground flat to obtain 2 mm thick slices in which conical preparations were made (N = 10). Tannin-containing plant extracts were applied to dentin before the application of the restorative system, as follows: control group (untreated, CTL), chlorhexidine 0.12% (CHX), mastruz (Dysphania ambrosioides, MTZ), cat’s claw (Uncaria tomentosa, CTC), guarana (Paullinia cupana, GUA), galla chinensis (Rhus chinensis, GCH), and tannic acid (extracted from Acacia decurrens, TNA). The push-out bond strength test was conducted (0.5 mm/min). Dentin biomodification was assessed by the modulus of elasticity and mass change in bovine tooth sections (0.5 × 1.7 × 7.0 mm). The dentin staining after extract treatments of dentin slices was compared. The dentin surface wettability was also evaluated by means of the contact angles of the adhesive system with the dentin surface and compared with the untreated control group. Data were subjected to ANOVA/Tukey’s test (α = 0.05). Results. The bond strength of the restoratives to dentin was not significantly improved by the plant extracts, irrespective of the evaluation time ( p > 0.05 ). Except for TNA, the elastic modulus of demineralized dentin significantly reduced after treatment with the plant extracts ( p < 0.05 ). The dentin staining correlated with the tannin content of the extracts. The contact angle was significantly reduced when treated with CTC, GCH, and TNA. Conclusions. The tannin-containing extracts had a questionable effect on the longevity of bonded restorations. The dentin modulus was negatively affected by the extract treatments. Although some of the extracts changed the contact angle, which seems to improve the adhesive monomer permeation, the tannin-rich plant extract application prior to adhesive application was proven to be clinically unfeasible due to dentin staining.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influence of Dentin Priming with Tannin-Rich Plant Extracts on the Longevity of Bonded Composite Restorations

Polassi

Oliveira

Carvalho

et al. 2021

The Scientific World Journal

Self Cite

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STMP and PVPA as Templating Analogs of Noncollagenous Proteins Induce Intrafibrillar Mineralization of Type I Collagen via PCCP Process

Wang,

Zhang,

Shen

et al. 2024

Adv Healthcare Materials

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The phosphorylated noncollagenous proteins (NCPs) play a vital role in manipulating biomineralization, while the mechanism of phosphorylation of NCPs in intrafibrillar mineralization of collagen fibril has not been completely deciphered. Poly(vinylphosphonic acid) (PVPA) and sodium trimetaphosphate (STMP) as templating analogues of NCPs induce hierarchical mineralization in cooperation with indispensable sequestration analogues such as polyacrylic acid (PAA) via polymer‐induced liquid‐like precursor (PILP) process. Herein, we propose STMP‐Ca and PVPA‐Ca complexes to achieve rapid intrafibrillar mineralization through polyelectrolyte‐Ca complexes pre‐precursor (PCCP) process. This strategy is further verified effectively for remineralization of demineralized dentin matrix both in vitro and vivo. Although STMP micromolecule fails to stabilize amorphous calcium phosphate (ACP) precursor, STMP‐Ca complexes facilely permeate into intrafibrillar interstices and trigger phase transition of ACP to hydroxyapatite within collagen. In contrast, PVPA‐stabilized ACP precursors lack liquid‐like characteristic and crystallize outside collagen due to rigid conformation of PVPA macromolecule, while PVPA‐Ca complexes infiltrate into partial intrafibrillar intervals under electrostatic attraction and osmotic pressure as evidenced by intuitionistic three‐dimensional stochastic optical reconstruction microscopy (3D‐STORM). The study not only extends the variety and size range of polyelectrolyte for PCCP process but also sheds light on the role of phosphorylation for NCPs in biomineralization.This article is protected by copyright. All rights reserved

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Assessing the impact of different Urushiol primer solvents on dentin remineralization and bond strength

Bai,

Chen,

Wei

et al. 2024

Clin Oral Invest

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The interaction of sodium trimetaphosphate with collagen I induces conformational change and mineralization that prevents collagenase proteolytic attack

Cited by 9 publications

References 45 publications

Influence of Dentin Priming with Tannin-Rich Plant Extracts on the Longevity of Bonded Composite Restorations

Influence of Dentin Priming with Tannin-Rich Plant Extracts on the Longevity of Bonded Composite Restorations

STMP and PVPA as Templating Analogs of Noncollagenous Proteins Induce Intrafibrillar Mineralization of Type I Collagen via PCCP Process

Assessing the impact of different Urushiol primer solvents on dentin remineralization and bond strength

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