The interaction of working memory performance and episodic memory formation in patients with Korsakoff's amnesia

Geldorp, Bonnie van; Bergmann, Heiko; Robertson, Johanna; Wester, Arie J.; Kessels, Roy P. C.

doi:10.1016/j.brainres.2011.11.036

Cited by 20 publications

(24 citation statements)

References 31 publications

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“…Two additional middle-aged adults and three additional older adults were successfully tested, but performed below chance level on the working memory task (cf. Van Geldorp et al, 2012). All participants provided written informed consent.…”

Section: Participantsmentioning

confidence: 99%

“…For more detailed information on the group characteristics, see Table 1. The group of middle-aged adults also took part in the study described in Van Geldorp et al (2012). Two additional middle-aged adults and three additional older adults were successfully tested, but performed below chance level on the working memory task (cf.…”

Section: Participantsmentioning

confidence: 99%

“…Recently, we examined these explanations in a study in patients with diencephalic-hippocampal amnesia due to Korsakoff's syndrome, testing both working memory binding and subsequent episodic memory (Van Geldorp, Bergmann, Robertson, Wester, & Kessels, 2012). In this study, participants were required to maintain two house-face pairs over a delay period of either 3 or 6 seconds.…”

mentioning

confidence: 98%

“…We reported that these amnesia patients showed deficits in working memory binding, over both short and longer delays. Moreover, longer delays did not improve the subsequent memory performance (Van Geldorp et al, 2012).…”

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confidence: 99%

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Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

Geldorp

Heringa

Berg

et al. 2015

Journal of Clinical and Experimental Neuropsychology

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Section: Participantsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

mentioning

confidence: 98%

mentioning

confidence: 99%

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Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

Geldorp

Heringa

Berg

et al. 2015

Journal of Clinical and Experimental Neuropsychology

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“…This means that integrating multisensory information in working memory may come at a cost when the central executive has to compete for resources with other information processes. Later Baddeley [43,44] added a fourth component, the episodic buffer, which can be seen as the gateway to long term memory [45], amongst others to explain effects of chunking or binding. The multisensory nature of encoding and decoding information suggests that a multisensory presentation of landmarks may improve the short as well as long term memory processes underlying navigational performance.…”

Section: Multisensory Memory Of Landmarksmentioning

confidence: 99%

Navigating virtual mazes: The benefits of audiovisual landmarks

Werkhoven

Erp²,

Philippi

2014

Displays

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It has been shown that multisensory presentation can improve perception, attention, and object memory compared with unisensory presentation. Consequently, we expect that multisensory presentation of landmarks can improve spatial memory and navigation. In this study we tested the effect of visual, auditory and combined landmark presentations in virtual mazes on spatial memory and spatial navigation. Nineteen participants explored four different virtual mazes consisting of nodes with landmarks and corridors connecting them. Each maze was explored for 90 seconds. After each exploration, participants performed the following tasks in fixed order: 1) draw a map of the maze, 2) recall adjacent landmarks for three given landmarks, 3) place all landmarks on the map of the maze, and 4) find their way through the maze to locate five given landmarks in fixed order. Our study shows significant effects of multisensory versus unisensory landmarks for the maze drawing task, the adjacency task, and the wayfinding task. Our results suggest that audiovisual landmark presentations improve spatial memory and spatial navigation performance in virtual environments.

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Function and Dysfunction of Prefrontal Brain Circuitry in Alcoholic Korsakoff’s Syndrome

Oscar‐Berman

2012

Neuropsychol Rev

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The signature symptom of alcohol-induced persisting amnestic disorder, more commonly referred to as alcoholic Korsakoff’s syndrome (KS), is anterograde amnesia, or memory loss for recent events, and until the mid 20th Century, the putative brain damage was considered to be in diencephalic and medial temporal lobe structures. Overall intelligence, as measured by standardized IQ tests, usually remains intact. Preservation of IQ occurs because memories formed before the onset of prolonged heavy drinking — the types of information and abilities tapped by intelligence tests — remain relatively well preserved compared with memories recently acquired. However, clinical and experimental evidence has shown that neurobehavioral dysfunction in alcoholic patients with KS does include nonmnemonic abilities, and further brain damage involves extensive frontal and limbic circuitries. Among the abnormalities are confabulation, disruption of elements of executive functioning and cognitive control, and emotional impairments. Here, we discuss the relationship between neurobehavioral impairments in KS and alcoholism-related brain damage. More specifically, we examine the role of damage to prefrontal brain systems in the neuropsychological profile of alcoholic KS.

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The interaction of working memory performance and episodic memory formation in patients with Korsakoff's amnesia

Cited by 20 publications

References 31 publications

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

Navigating virtual mazes: The benefits of audiovisual landmarks

Function and Dysfunction of Prefrontal Brain Circuitry in Alcoholic Korsakoff’s Syndrome

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