The interactions between hemostasis and resistance training: a review

Nascimento, Dahan da Cunha; Neto, Frederico Ribeiro; Santana, Frederico Santos de; Silva, Renato André Sousa da; Santos-Neto, Leopoldo Luiz dos; Bálsamo, Sandor

doi:10.2147/ijgm.s29197

Cited by 10 publications

(15 citation statements)

References 25 publications

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“…The use of TEG has been an important tool for the evaluation of the coagulation index in rats [ 18 , 19 ] and in this study TEG was used to assess individual hemodynamic changes in response to LPS and exercise. Moreover, our findings are consistent with previous publications that report a beneficial effect of exercise on coagulation parameters and an overall enhanced fibrinolytic state [ 47 , 49 ].…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, we previously demonstrated that inflammation-induced maternal hemostatic alterations, detected systemically using TEG, are comparable to hemostatic alterations detected locally at the utero-placental interface in a model of inflammation-induced fetal demise [ 18 ]. Though some studies have described a pro-thrombotic effect of high intensity exercise (>75% of VO 2max ) [ 45 , 46 ], there is evidence that exercise prevents thrombosis during hospitalization and prolonged bedtime periods in non-pregnant individuals, and that exercise improves the hemostatic profile [ 47 , 48 ]. In the present study, exercise normalized LPS-induced alterations in TEG parameters such that the values were not different from those of sedentary, saline-treated, control rats.…”

Section: Discussionmentioning

confidence: 99%

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Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats

et al. 2016

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Fetal growth restriction (FGR) and coagulopathies are often associated with aberrant maternal inflammation. Moderate-intensity exercise during pregnancy has been shown to increase utero-placental blood flow and to enhance fetal nutrition as well as fetal and placental growth. Furthermore, exercise is known to reduce inflammation. To evaluate the effect of moderate-intensity exercise on inflammation associated with the development of maternal coagulopathies and FGR, Wistar rats were subjected to an exercise regime before and during pregnancy. To model inflammation-induced FGR, pregnant rats were administered daily intraperitoneal injections of E. coli lipopolysaccharide (LPS) on gestational days (GD) 13.5–16.5 and sacrificed at GD 17.5. Control rats were injected with saline. Maternal hemostasis was assessed by thromboelastography. Moderate-intensity exercise prevented LPS-mediated increases in white blood cell counts measured on GD 17.5 and improved maternal hemostasis profiles. Importantly, our data reveal that exercise prevented LPS-induced FGR. Moderate-intensity exercise initiated before and maintained during pregnancy may decrease the severity of maternal and perinatal complications associated with abnormal maternal inflammation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats

et al. 2016

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“…Blood hemostasis represents the interaction between systems controlling coagulation and fibrinolysis. It has been shown that regular exercise may positively impact the hemostatic system by balancing fibrinolytic and coagulation blood profiles in healthy individuals and patients with known diseases 1,2. Acute bouts of resistance training (RT) without blood flow restriction (BFR) in middle-aged men with coronary artery disease increased tissue plasminogen activator (tPA) and decreased plasminogen activator inhibitor-1 (PAI-1) 3.…”

Section: Introductionmentioning

confidence: 99%

<p>Effects of blood flow restriction exercise on hemostasis: a systematic review of randomized and non-randomized trials</p>

Nascimento¹,

Petriz²,

Oliveira³

et al. 2019

IJGM

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Background Blood flow restriction (BFR) exercise has shown to induce a positive influence on bone metabolism and attenuate muscle strength loss and atrophy in subjects suffering from musculoskeletal weakness. Despite the known benefits of BFR exercise, it remains unclear whether or not the pressurization of blood vessels damages the endothelial cells or increases risk for formation of thrombi. Thus, the effects of BFR exercise on coagulation, fibrinolysis, or hemostasis, remains speculative. Objective The aim of the present study was to perform a systematic review of the short and long- term effects of BFR exercise on blood hemostasis in healthy individuals and patients with known disease (ie, hypertension, diabetes, obesity, and ischemic heart disease). Data Sources A systematic review of English and non-English articles was conducted across PubMed, Science Direct, and Google Scholar databases, including reference lists of relevant papers. Study quality assessment was evaluated using the modified version of Downs and Black checklist. Search results were limited to exercise training studies investigating the effects of BFR exercise on blood hemostasis in healthy individuals and patients with disease. Level of evidence was determined according to the criteria described by Oxford Center for Evidence-Based Medicine. Study selection Only randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) that examined the effects of exercise with BFR exercise vs exercises without BFR on blood hemostasis in healthy individuals and patients were included. Data extraction Nine studies were eligible (RCT =4; NRCT =5). Results The average score on the Downs and Black checklist was 11.22. All studies were classified as having poor methodological quality wherein the level of evidence provided in all reviewed studies was level IIb only (ie, poor quality RCTs). Conclusion Considering the limitations in the available evidence, firm recommendations cannot be provided.

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“…This is especially important, as several studies have suggested that both resistance exercise as well as high-protein intake might affect the coagulation system. 4 – 6 For example, despite using different methodologies, studies investigating the effects of resistance exercise on the hemostatic system have consistently reported increases in t-PA levels in response to resistance training. 4 – 6 Data reporting the effects of high protein intake on the coagulation system are, however, contradictory at this point.…”

Section: Introductionmentioning

confidence: 99%

“… 4 – 6 For example, despite using different methodologies, studies investigating the effects of resistance exercise on the hemostatic system have consistently reported increases in t-PA levels in response to resistance training. 4 – 6 Data reporting the effects of high protein intake on the coagulation system are, however, contradictory at this point. On one hand it has been shown that high protein intake has prothrombotic effects, as it increases the fibrinogen levels 7 and decreases bleeding times.…”

Section: Introductionmentioning

confidence: 99%

Effects of Exercise and Nutrition on the Coagulation System During Bedrest Immobilization

Waha

Goswami²,

Schlagenhauf³

et al. 2015

Medicine

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Immobilization in hospitalized medical patients or during simulation of spaceflight induced deconditioning has been shown to be associated with loss of muscle mass and bone. Resistance vibrating exercise (RVE) and/or high protein diet are countermeasures, which are capable of mitigating the adverse effects of immobilization. We investigated the effect of these countermeasures on the coagulation system. Two groups of volunteers, each of whom performed such countermeasures, were enrolled in the study. Volunteers, who did nothing while bed rested, served as controls.The berest and the intervention protocols were carried out at Clinique d’ Investigation, MEDES, Toulouse, France.Eleven healthy men volunteered for this randomized crossover study. The subjects underwent 21 day of 6° head down bed rest (HDBR) followed by a washout period of 4 months. The first group followed an exercise schedule using resistance-vibrating exercise (RVE group). The second group also used the RVE but complemented it with high-protein supplement diet (NeX group). The third group only did bed rest.The highly sensitive methods calibrated automated thrombography (CAT) and thrombelastometry (TEM) were applied to monitor hemostatic changes.In all 3 groups, the hemostatic system shifted toward hypocoagulability during bed rest. For example, peak and thrombin formation velocity (VELINDEX) reduced in this period. Interestingly, a tendency toward hypercoagulation was observed during re-ambulation. In all 3 groups, ttPeak and StartTail were reduced, and Peak and VELINDEX (except in the RVE group) were significantly higher in relation to baseline values.Influence of bed rest on the coagulation system in the 2 groups performing countermeasures (RVE and NeX group) was the same as in the control bed-rested group. Clotting does not seem to be worsened by prolonged immobilization, or by countermeasures such as RVE/exercise or high-protein supplementation during immobilization. Therefore, only hospitalized medical patients at an elevated risk for thrombosis should be treated with anticoagulants. However, clinicians have to be aware that the re-ambulation period following immobilization might be associated with an elevated risk of thrombotic events.

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The interactions between hemostasis and resistance training: a review

Cited by 10 publications

References 25 publications

Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats

Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats

<p>Effects of blood flow restriction exercise on hemostasis: a systematic review of randomized and non-randomized trials</p>

Effects of Exercise and Nutrition on the Coagulation System During Bedrest Immobilization

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