The Interactome Hypothesis of Depression

Abstract

It has long been known that the most important function of platelets is to stop the flow of blood from wounds with the help of a set of enzymes, proteins, and lipids supporting complex metabolic clot-forming mechanisms. It is also known that there are close correlations, both enzymatic and metabolic, between platelets and nerve cells with respect to the metabolism of several neurotransmitters such as serotonin, dopamine, GABA, etc. Platelets, which serve an historic role as biological markers in psychiatry, can in fact be regarded as virtual "circulating neurons" or "brain ambassadors" that may offer a significant advantage in understanding the neurophysiology of psychiatric disorders including depression. Critical points of potential specific linkage between platelets and depression include serotonin and membrane platelet fatty acids in relation to the cytoskeletal quantum-nanowire network. This paper advances an "interactome" hypothesis of possible connections among enterochromaffin cells, serotonin, platelets and cytoskeletal proteins related to brain neurons with implications regarding the genesis of depressive psychopathology.

Major Depression and Bipolar Disorder: The Concept of Symmetry Breaking

“…It is not, in fact, understandable, how an index, that provides, albeit indirectly, the degree of viscosity of the membrane, can be elaborated by the SOM which distributes the patients on a map, without knowing the concept of membrane viscosity, and, of course, the significance and biological properties of fatty acids involved. These features, which were deeply examined through extensive clinical evaluations, led to a series of considerations about the role of the membrane viscosity with respect to the serotonin reuptake (Heron, 1980;Lee, 1985) and the phenomena that influence its connections with the Gsα protein and with the cytoskeleton (Donati, 2008;Cocchi, 2010b).…”

The Suicide Attempt in an Artificial Neural Network (Self Organizing Map)

“…The children's platelet fatty acids profile has a very high concentration of stearic acid, and as a result, the children's platelet membranes are highly saturated with increased viscosity corresponding to a higher uptake of serotonin with respect to the MD condition [23,25,26]. The concept of cell membrane viscosity, especially that of the neuron and platelet, also responsible of the central government of that bio-molecular intracellular complex called interactome and of its influence on quantum chemical scale of the ion channels, is often missed in its involvement in many psychiatric conditions [11]. Under this evidence and according to the classification of the children over the SOM we hypothesize that it is very difficult to have a classic condition of Major Depression in children.…”

The Strange History of a Nobel Prize Winner Who Predicted the Meaning of Research

“…The molecular pathway of depression and how it impacts consciousness ( Figure 5) was implemented as a result of discussions that took place between Kary Mullis, Mark Rasenick, and Stuart Hameroff. The results of these amazing conversations are revealed, showing clear experimental evidence between the element of conjunction with the amendments to the conscious state (Cocchi et al, 2010d). Figure 5 shows the mathematical passages to explain the main cell molecular pathway that is involved in major depression (MD) and consciousness.…”