Opioid dependence, misuse, and overdoses are serious public health problems faced by many countries. Particularly in the United States (US) and Canada, the use of opioids has surged since the late 1990s. This trend is observed for both illicit opioids, such as heroin, and prescription opioids. Today, both countries are in the midst of a devastating opioid epidemic, which is likely to become even worse during the COVID-19 pandemic. 1 Some observers are worried that this epidemic could soon swap over to other countries. 2 In Europe, overdose deaths have recently begun to increase again too. Especially the emergence of potent synthetic opioids, such as fentanyl, is alarming (EMCDDA, 2017). To address this crisis and understand its persistence, it is crucial to identify important predictors of opioid dependence.Opioid dependence not only has a negative impact on users themselves but harms entire families. Children are particularly vulnerable. The incidence of neonatal abstinence syndrome, a condition that occurs if babies are exposed to opioids in utero, has increased almost fourfold between 2004(Tolia et al., 2015. Affected babies experience severe withdrawal symptoms up to 6 months after birth (McQueen & Murphy-Oikonen, 2016) and are more likely to have adverse outcomes in later life (Maguire et al., 2016). Children exposed to parental opioid dependence postnatally face obstacles as well. They are more likely to grow up in an unstable environment with economic and emotional challenges, such as secrecy, loss, conflict, violence, and fear (Nunes et al., 2000). Such childhood experiences are associated with severe limitations in economic and social functioning later in life, which may increase the likelihood of children's own substance abuse. Thus, the family is potentially an important factor in explaining opioid addiction.