The Interleukin-33/ST2 Axis Enhances Lung-Resident CD14+ Monocyte Function in Patients with Non-Small Cell Lung Cancer

Lv, Wang; Mei, Xingke; Liu, Xiaogang; Guo, Lan-Ping; Yang, Bo; Chen, Renan

doi:10.1080/08820139.2022.2130075

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…sST2 , a soluble form of ST2 , has been shown to involve in the inflammatory tumor microenvironment and the progression of non-small cell lung cancer ( Hong et al, 2019 ; Chang et al, 2020 ). A prvious study found that the IL-33 / ST2 axis enhances lung-resident CD14 + monocyte function in patients with non-small cell lung cancer ( Wang et al, 2023 ). In this study, the expression level of IL1RL1 was found to be significantly different between normal and LUAD and LUSC tissues based on TCGA database, and IL1RL1 was mainly involved in IL-1 family signaling pathways, cytokine signaling in immune system, and innate lymphoid cells differentiation.…”

Section: Discussionmentioning

confidence: 99%

IL1RL1 polymorphisms rs12479210 and rs1420101 are associated with increased lung cancer risk in the Chinese Han population

Li,

Zhang,

Cheng

et al. 2023

Front. Genet.

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Background: Lung cancer is one of the most common human malignant diseases. In this study, we aimed to explore the association between IL1RL1 genetic polymorphisms and lung cancer risk in the Chinese Han population.Methods: We selected and genotyped six SNPs in the IL1RL1 gene using the Agena MassARRAY system in 507 lung cancer patients and 507 healthy controls. The association between IL1RL1 variants and lung cancer risk was assessed using logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Multi-factor dimensionality reduction (MDR) was used to analyze the impact of SNP-SNP interactions on the risk of lung cancer.Results: The results of overall analysis indicated that rs12479210 (T vs. C: OR = 1.42, FDR-p = 0.002; TC vs. CC: OR = 1.70, FDR-p < 0.0001; TT vs. CC: OR = 1.77, FDR-p = 0.032; TT-TC vs. CC: OR = 1.71, FDR-p = 0.001; additive: OR = 1.44, FDR-p = 0.001) and rs1420101 (T vs. C: OR = 1.31, FDR-p = 0.036; TT-TC vs. CC: OR = 1.42, FDR-p = 0.031; additive: OR = 1.30, FDR-p = 0.030) were associated with an increased the risk of lung cancer among the Chinese Han population. Stratified analysis also found the association between these two SNPs and lung cancer risk. However, there were no significant association observed between the other four SNPs (rs3771180, rs3771175, rs10208293, and rs10197862) in IL1RL1 and lung cancer risk. Furthermore, MDR analysis showed that rs12479210 was the best single model with the highest testing accuracy (0.566) and perfect CVC (10/10) for predicting lung cancer risk. The expression level of the IL1RL1 gene is lower in lung cancer tissue than normal tissue, and there are significant differences in the expression levels of IL1RL1 between rs12479210 and rs1420101 genetypes in lung cancer tissue (p < 0.05).Conclusion: Our findings suggest that IL1RL1 genetic variants (rs12479210 and rs1420101) are associated with an increased lung cancer risk in the Chinese Han population. These risk variants may serve as biomarkers for the prevention and treatment of lung cancer.

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Section: Discussionmentioning

confidence: 99%

IL1RL1 polymorphisms rs12479210 and rs1420101 are associated with increased lung cancer risk in the Chinese Han population

Li,

Zhang,

Cheng

et al. 2023

Front. Genet.

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“…Through the recruitment of CD8 + T cells, NK, eosinophils (EOS), and dendritic cells (DC), and the induction of IFN‐γ, IL‐33 may impede tumor progression (Dominguez et al 2017). IL‐33 enhances target cell death induced by CD14 + monocytes in non‐small cell lung cancer patients (Wang et al 2023a). Exogenous IL‐33 facilitates the secretion of IL‐5 by ILC2s, which further leads to the recruitment of EOS.…”

Section: Cytokine Il‐3(sil‐33)mentioning

confidence: 99%

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction

Wang,

Tang

2023

J. Cell Commun. Signal.

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Small ubiquitin-related modifier USP21 Ubiquitin-specific peptidase 21 SMAD3 Smad family member 3 TSLP Thymic Stromal Lymphopoietin hBD2 Human beta-defensin 2 GATA3 GATA-binding protein 3 HDACs Histone deacetylases PARP1 (ADP-ribose) polymerase 1 ATM Ataxia-telangiectasia mutated BER Base excision repair DSB DNA double-strand break DDR DNA damage response DDIT3 DNA damage-inducible transcript 3 TNF-α Tumor necrosis factor-α,SASP,senescenceassociated secretory phenotype PROTACs Proteolysis-targeting chimeras DUBTACs Deubiquitinase targeting chimeras TPS Targeted protein stabilization SENP2 SUMO specific protease 2 Nanhong Tang

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Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases

He,

Wu,

Zheng

et al. 2024

Cytokine & Growth Factor Reviews

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The Interleukin-33/ST2 Axis Enhances Lung-Resident CD14+ Monocyte Function in Patients with Non-Small Cell Lung Cancer

Cited by 4 publications

References 36 publications

IL1RL1 polymorphisms rs12479210 and rs1420101 are associated with increased lung cancer risk in the Chinese Han population

IL1RL1 polymorphisms rs12479210 and rs1420101 are associated with increased lung cancer risk in the Chinese Han population

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction

Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases

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