The Interleukin 6 -<i>572 G&gt;C</i> (rs1800796) Polymorphism Is Associated with the Risk of Developing Acute Coronary Syndrome

Fragoso, José Manuel; Delgadillo, Hilda; Juárez‐Cedillo, Teresa; Rodrı́guez-Pérez, José Manuel; Vallejo, Maité; Pérez-Méndez, Óscar; Álvarez-León, Edith; Peña‐Duque, Marco Antonio; Martínez-Ríos, Marco Antonio; Vargas‐Alarcón, Gilberto

doi:10.1089/gtmb.2010.0001

Cited by 20 publications

(8 citation statements)

References 36 publications

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“…Contrary to our conclusions; Fragoso and colleagues showed that IL-6 572 G / C polymorphism in their Mexican population may be related to the risk of developing acute coronary syndrome [26].…”

Section: Bp 101 Bp 62 Bp Mcontrasting

confidence: 99%

INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

Güler¹

2019

ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology

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The most important characteristic of coronary artery disease, which is one of the most prevalent and most important healthy problem today, is that it can lead to life-threatening myocardial infarction in advanced stages. It is more important to take protective preventions by knowing the risk factors that cause the disease rather than the treatment of this disease. This study included determining the frequency of interleukin-6 (IL-6) gene 572 G / C polymorphism in individuals with coronary artery disease (CAD) and determining the role of that polymorphism in the development of CAD. In the current study, DNAs were isolated from the blood of a total of 185 individuals (103 coronary patients and 82 controls) by the salt method. Genotypes of IL-6 572 G / C polymorphism were detected by using molecular techniques (PCR, RFLP and electrophoresis) from these isolated DNAs. The results obtained were evaluated statistically. According to these results, the frequencies of 572 G / C genotype were 83% for GC, 17% for GC, 0% for CC in control subjects for CAD; whereas in patients, GG 72%, GC 28% and CC 0% were detected in the patients. No statistically considerable difference was determined between control and patient groups in terms of frequency of 572 G / C alleles and the GG genotype was significantly higher in the patient group. Based on the results of the currently study, we can say that there is no correlation between coronary artery disease and IL-6 572 G / C polymorphism frequency.

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Section: Bp 101 Bp 62 Bp Mcontrasting

confidence: 99%

INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

Güler¹

2019

ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology

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“…The IL-6 (-572 G>C, rs1800796) polymorphism is associated with the risk of developing acute coronary syndrome in the Mexican population. 54 In similar studies in the Netherlands and Germany, no relationship was found between this SNP and cardiovascular disease (in patients without other diseases). In patients with diabetes mellitus type 2 (with the GG genotype), there is a susceptibility to develop peripheral vascular disease of the arteries, which is accompanied with higher fibrinogen and CRP serum levels.…”

Section: Associations With Human Diseasesmentioning

confidence: 90%

Cytokines of the Immune System

Dembić

2015

The Cytokines of the Immune System

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“…Sie et al (2006) argue that IL-6174 polymorphism is effective in transcribing the Interleukin-6 (IL-6) gene and, consequently, in the plasma level of IL-6 [21]. On the other hand, it is argued that there has been an association between the IL-6572 gene and the occurrence of atherosclerosis, coronary artery disease, and MI [22].…”

Section: Introductionmentioning

confidence: 99%

The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

et al. 2021

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Background Coronary Artery Disease (CAD) is caused by the blockage of the coronary arteries. it is argued that there has an association between the Interleukin-6 gene and the occurrence of atherosclerosis, coronary artery disease, Due to the short half-life and high variability of Interleukin-6 (IL-6), limited studies have been performed on the association of serum levels of interleukin-6 with coronary artery disease. The aim of this study is to investigate the relationship between IL-6 gene polymorphisms and coronary artery disease. Methods This study was conducted as a meta-analysis of selected articles with no lower time limit and upto March 2020. Articles related to the subject were obtained by searching several data sources,such as the SID, IranDoc, Scopus, Embase, Web of Science (ISI), PubMed, Science Direct, and Google Scholar databases. The heterogeneity of the studies was assessed using the I2 index in the Comprehensive Meta-Analysis software. Results The GG genotype of the IL-6174 G> C polymorphism with a 0.8 odds ratio tended to reduce the risk of CAD by 20%. The odds ratio of CAD in CG and GG genotypes were found to be 1.16 and 1.48 times respectively, indicating the increasing effect of these two genotypes. In the IL-6-572 C>G polymorphism, CG and GG genotypes increased the risk of CAD by 1.21 and 1.27 times respectively, and the CC genotype tended to reduce the risk of CAD by 15%, considering the odds ratio of 0.85. Conclusion This study showed a relationship between IL-6174G> C and Interleukin-6 (IL-6) 572 C>G genes and coronary artery disease. Moreover, the protective effects of GG genotype in IL-6 gene 174 G> C and CC genotype in IL-6 gene 572 C>G gene were reported. The study also confirmed that the CG and CC genotypes of the G>C IL-6174 gene have an increasing effect on coronary artery disease. Moreover, CG and GG genotypes in the IL-6 gene 572 C>G increased the risk of developing CAD. It should be noted that the increased risk of developing CAD was limited to meta-analytic studies in reported literatures.

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The Interleukin 6 -572 G>C (rs1800796) Polymorphism Is Associated with the Risk of Developing Acute Coronary Syndrome

Abstract: the results suggest that IL-6 -572 G>C (rs1800796) polymorphism could be involved in the risk of developing ACS in Mexican individuals.

Cited by 20 publications

References 36 publications

INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

Cytokines of the Immune System

The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

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