The International Haemovigilance Network Database for the Surveillance of Adverse Reactions and Events in Donors and Recipients of Blood Components: technical issues and results

Politis, C.; Wiersum, Jo; Richardson, Clive; Robillard, Pierre; Jørgensen, Jens Otto Lunde; Renaudier, P.; Faber, Jean‐Claude; Wood, Erica M.

doi:10.1111/vox.12447

Cited by 79 publications

(73 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Transfusion of blood in trauma patients may increase risk of morbidity and mortality . It may also be associated with adverse events such as transfusion‐related acute lung injury, transfusion‐related circulatory overload, and infections . Prolonged red blood cell storage may potentiate these effects.…”

mentioning

confidence: 99%

“…1,2 It may also be associated with adverse events such as transfusion-related acute lung injury, transfusion-related circulatory overload, and infections. 3 Prolonged red blood cell storage may potentiate these effects. Indeed, prolonged storage of blood before transfusion can lead to biochemical and biomechanical changes collectively known as "storage lesion."…”

mentioning

confidence: 99%

See 1 more Smart Citation

Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial

Green¹,

Erdoğan

Lacroix

et al. 2018

Transfusion

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial

Green¹,

Erdoğan

Lacroix

et al. 2018

Transfusion

View full text Add to dashboard Cite

show abstract

“…Hence, a rudimentary imputability assessment was taking place since the system was filtering out cases where the imputability was unlikely or excluded. That same practice is suggested for EU reporting and is in place for data sharing in the IHN‐owned and sponsored International Database for Surveillance of Transfusion Adverse Reactions and Events (ISTARE) . Nevertheless, both those systems additionally request a formal imputability assessment, and this makes explicit the fact that adverse reactions and adverse events which have a temporal association with transfusion may not have been caused by the transfusion.…”

Section: Discussion: Some Definition‐related Issues From Practicementioning

confidence: 99%

Definitions in haemovigilance: guiding principles and current state of development of international reference definitions

Wiersum‐Osselton¹,

Wood

Schipperus³

2014

ISBT Science Series

View full text Add to dashboard Cite

Background Haemovigilance systems capture data on adverse reactions and infections in recipients of blood transfusions as well as on errors and incidents in the transfusion chain. The objective is to analyse them and make recommendations for improving transfusion safety. Many haemovigilance systems also collect data on complications in blood donors with a view to monitoring and improving blood donor safety. Standardized definitions are necessary for classifying and comparing data in all these domains and at all levels.Method Since 2004, at international meetings of blood transfusion professionals, members the International Haemovigilance Network (IHN) and the haemovigilance working party of the International Society for Blood Transfusion (ISBT) have collaborated in developing and validating definitions for non-infectious transfusion complications, errors and incidents in the transfusion chain as well as adverse reactions in blood donors. From 2012, contacts with other groups including the World Health Organisation (WHO) have been put in place to ensure wide consultation as well as awareness and use of the definitions. ResultsStandardized definitions have been published for recipient adverse reactions, for complications of blood donation and for a limited number of types of incident in the transfusion chain. The ISBT haemovigilance working party and IHN are committed to ensuring that the definitions remain up-to-date and that revisions and improvements are conducted with wide consultation of professionals in relevant organizations worldwide. The haemovigilance working party and working party on transfusion-transmitted infections are collaborating on the development of definitions and criteria for assessing suspected transfusion-transmitted infections.Conclusion Internationally agreed definitions are available for registration and surveillance of complications of blood donation and most types of adverse reaction in patients receiving blood transfusions. For errors and incidents in the transfusion chain, further work is necessary to improve comparability of data between haemovigilance systems.

show abstract

“…An ATR is an undesirable response or effect in a patient that is temporally associated with the administration of blood or blood components . There are many aetiologies of ATRs , including haemolytic transfusion reactions and non‐haemolytic transfusion reactions such as febrile non‐haemolytic transfusion reactions (FNHTR), allergic reactions, transfusion‐related acute lung injury (TRALI) and transfusion‐associated circulatory overload (TACO) . The severity of each ATR was graded from 1 to 4, as follows: grade 1 (non‐severe), grade 2 (severe), grade 3 (life‐threatening) and grade 4 (death).…”

Section: Methodsmentioning

confidence: 99%

Adverse transfusion reactions in patients with aplastic anaemia or myelodysplastic syndromes

et al. 2019

View full text Add to dashboard Cite

Background and Objectives Patients with aplastic anaemia or myelodysplastic syndromes frequently receive transfusions in an attempt to correct anaemia and/ or thrombocytopenia, putting them at risk of adverse transfusion reactions. The aim of this study is to evaluate the incidence and the types of adverse transfusion reactions in these patients. Materials and MethodsAdverse transfusion reaction reported in transfused patients with aplastic anaemia or myelodysplastic syndromes from all the hospitals in the Auvergne-Rhône-Alpes region of France were extracted from the national haemovigilance database system and analysed. The types of adverse transfusion reactions, their incidence, their severity, the blood component involved and its imputability were evaluated.Results From 1 January 2010 to 30 June 2016, 7174 adverse transfusion reactions were reported. Seventy adverse transfusion reactions (0Á9%) were reported in patients with aplastic anaemia and 193 (2Á7%) in patients with myelodysplastic syndromes. Febrile non-haemolytic transfusion reaction was the most common reaction both aplastic anaemia (23 cases, 33Á0%) and myelodysplastic syndrome (56 cases, 29Á0%). Post-transfusion red blood cell alloimmunization was also high in both these groups (17Á1% in patients with aplastic anaemia and 22Á3% in patients with myelodysplastic syndrome) frequently involving anti-JK1 (Jk a ) specificity.Conclusion Febrile non-haemolytic transfusion reaction was the most common adverse transfusion reaction in patients with aplastic anaemia or myelodysplastic syndromes who received transfusions. Post-transfusion red blood cell alloimmunization was also observed frequently, but the use of RH-KEL 1 (Rhesus-Kell)matched red blood cell concentrates reduces this risk.

show abstract

The International Haemovigilance Network Database for the Surveillance of Adverse Reactions and Events in Donors and Recipients of Blood Components: technical issues and results

Abstract: ISTARE is a well-established surveillance tool offering important contributions to international efforts to maximize transfusion safety.

Cited by 79 publications

References 7 publications

Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial

Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial

Definitions in haemovigilance: guiding principles and current state of development of international reference definitions

Adverse transfusion reactions in patients with aplastic anaemia or myelodysplastic syndromes

Contact Info

Product

Resources

About