The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation

He, Ruiqiao; Li, Pan; Wang, Jinfeng; Cui, Bota; Zhang, Faming; Zhao, Fangqing

doi:10.1080/19490976.2022.2100197

Cited by 35 publications

(27 citation statements)

References 69 publications

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“…Then, they defined the ratio of colonizers to residents after FMT as C2R and found that C2R was significantly elevated in the FMT response group compared to the failure group, suggesting the successful colonization of more bacteria from the donor in the gut of the recipients. These results imply the importance of diversity changes before and after FMT and bacterial colonization in IBD patients, which was also find in CDI patients who are also characterized by gut dysbiosis (85).…”

Section: Fecal Microbiota Transplantationsupporting

confidence: 65%

“…This suggests that FMT may be a potential rescue therapy for the treatment of acute exacerbations of IBD, or even as an initial standard treatment regimen. He et al (85) investigated the microbiome changes before and after FMT in IBD patients. In their study, 3-5 Units of fresh fecal bacteria (1 U = 1 × 10 13 cells) in suspension (1 U 10.3389/fmed.2022.1023896 with 20 ml saline) was delivered to patient's gut.…”

Section: Fecal Microbiota Transplantationmentioning

confidence: 99%

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Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates

et al. 2022

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Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease that occurs in the intestinal tract. It is mainly divided into two subtypes, i.e., the Crohn’s disease (CD) and ulcerative colitis (UC). At present, its pathogenesis has not been fully elucidated, but it has been generally believed that the environment, immune disorders, genetic susceptibility, and intestinal microbes are the main factors for the disease pathogenesis. With the development of the sequencing technology, microbial factors have received more and more attention. The gut microbiota is in a state of precise balance with the host, in which the host immune system is tolerant to immunogenic antigens produced by gut commensal microbes. In IBD patients, changes in the balance between pathogenic microorganisms and commensal microbes lead to changes in the composition and diversity of gut microbes, and the balance between microorganisms and the host would be disrupted. This new state is defined as dysbiosis. It has been confirmed, in both clinical and experimental settings, that dysbiosis plays an important role in the occurrence and development of IBD, but the causal relationship between dysbiosis and inflammation has not been elucidated. On the other hand, as a classic research method for pathogen identification, the Koch’s postulates sets the standard for verifying the role of pathogens in disease. With the further acknowledgment of the disease pathogenesis, it is realized that the traditional Koch’s postulates is not applicable to the etiology research (determination) of infectious diseases. Thus, many researchers have carried out more comprehensive and complex elaboration of Koch’s postulates to help people better understand and explain disease pathogenesis through the improved Koch’s postulates. Therefore, focusing on the new perspective of the improved Koch’s postulates is of great significance for deeply understanding the relationship between dysbiosis and IBD. This article has reviewed the studies on dysbiosis in IBD, the use of microbial agents in the treatment of IBD, and their relationship to the modified Koch’s postulates.

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Section: Fecal Microbiota Transplantationsupporting

confidence: 65%

Section: Fecal Microbiota Transplantationmentioning

confidence: 99%

Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates

et al. 2022

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“…The concept of “super-donors” has been emerged as patients received their fecal materials exhibited higher remission rate, which might attribute to their diversified gut microbiota ( 32 ). Since it is difficult to find the super-donors, donor-recipient matching for FMT based on machine learning methods will be helpful for rational donor selection and the performance of precise FMT in the coming future ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Research trends on clinical fecal microbiota transplantation: A biliometric analysis from 2001 to 2021

Liu

Ouyang

2022

Front. Immunol.

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BackgroundNumerous studies on fecal microbiota transplantation (FMT) have been conducted in the past two decades. We aimed to assess the research trends and hotspots in the field of FMT through a quantitative method.Materials and MethodsThe clinical studies of FMT published from 2001 to 2021 were extracted from the Web of Science database. We analyzed the countries, institutions, authors, and keywords of these articles and visually illustrated using VOSviewer and CiteSpace software. The current application of FMT in clinical practice, including indications, efficacy, adverse events, as well as its methodology, such as donor, delivery route, were also evaluated.ResultsA total of 227 records were finally identified. The number and rate of annual publications increased gradually. The USA ranked highest in the number of publications. Harvard University was the most influential institution, and Digestive Diseases and Sciences was the most productive journal. Kassam Zain published the most papers, and the high-frequency keywords were mainly related to diseases and techniques. Healthy donors were the most widely used donors, and frozen stool had the highest frequency of use. The predominant delivery route was endoscopy followed by oral capsules and enema. FMT was most frequently performed for the treatment of recurrent Clostridium Difficile Infection. The overall efficacy of FMT was 76.88%, and the incidence of minor and severe adverse events were 11.63% and 1.59%, respectively.ConclusionsThis study delineated a comprehensive landscape of the advancement in FMT field. Although in its infancy, FMT is a burgeoning option for the treatment of a variety of diseases associated with gut dysbiosis. To improve the efficacy and reduce adverse events, future studies are warranted to optimize the methodology of FMT.

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“…In addition to probiotic interventions, other diet-based interventions and microbiome-based therapies, such as faecal microbiota transplantation (FMT), have also demonstrated successful results for the restoration of the normal microbiome (figure 2B). [113][114][115][116] Nonetheless, a recent study implemented FMT in one pregnant woman and reported the detection of donor-derived bacterial strains in the later-born infant, indicating vertical transmission during the perinatal period. 117 No further disorders have been observed in the offspring.…”

Section: Deviation Of the Maternal Gut Microbiome And Interventionsmentioning

confidence: 99%

Microbial transmission, colonisation and succession: from pregnancy to infancy

Xiao

Zhao

2023

Gut

Self Cite

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The microbiome has been proven to be associated with many diseases and has been used as a biomarker and target in disease prevention and intervention. Currently, the vital role of the microbiome in pregnant women and newborns is increasingly emphasised. In this review, we discuss the interplay of the microbiome and the corresponding immune mechanism between mothers and their offspring during the perinatal period. We aim to present a comprehensive picture of microbial transmission and potential immune imprinting before and after delivery. In addition, we discuss the possibility of in utero microbial colonisation during pregnancy, which has been highly debated in recent studies, and highlight the importance of the microbiome in infant development during the first 3 years of life. This holistic view of the role of the microbial interplay between mothers and infants will refine our current understanding of pregnancy complications as well as diseases in early life and will greatly facilitate the microbiome-based prenatal diagnosis and treatment of mother-infant-related diseases.

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The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation

Cited by 35 publications

References 69 publications

Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates

Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates

Research trends on clinical fecal microbiota transplantation: A biliometric analysis from 2001 to 2021

Microbial transmission, colonisation and succession: from pregnancy to infancy

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