The interpretation of single source and mixed DNA profiles

Taylor, Duncan; Bright, Jo‐Anne; Buckleton, John

doi:10.1016/j.fsigen.2013.05.011

Cited by 248 publications

(196 citation statements)

References 23 publications

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“…Interpretation methods that utilise peak height or area information, rather than the binary information of whether a peak height or area exceeds a threshold or not, have garnered much attention, and a variety of fully-continuous interpretation platforms have been developed [9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Probabilistic characterisation of baseline noise in STR profiles

Monich

Duffy

Médard

et al. 2015

Forensic Science International: Genetics

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Section: Introductionmentioning

confidence: 99%

“…Sometimes, noise is modelled implicitly as small peaks with mean zero [10,12]. In [13], a continuous modelling of the peak height is used if the peak exceeds a user defined analytical threshold. A quantitative computer evaluation of DNA mixtures is proposed in [15,16].…”

Section: Introductionmentioning

confidence: 99%

Probabilistic characterisation of baseline noise in STR profiles

Monich

Duffy

Médard

et al. 2015

Forensic Science International: Genetics

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“…genotyping using what has been termed 'semicontinuous' (where only allele information is used) or 'fully continuous' (where alleles and peak height information are used) [57][58][59][60][61][62][63].…”

Section: (C) Stronger Conclusion With Challenging Samplesmentioning

confidence: 99%

The future of forensic DNA analysis

Butler

2015

Phil. Trans. R. Soc. B

177

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One contribution of 15 to a discussion meeting issue 'The paradigm shift for UK forensic science'. The author's thoughts and opinions on where the field of forensic DNA testing is headed for the next decade are provided in the context of where the field has come over the past 30 years. Similar to the Olympic motto of 'faster, higher, stronger', forensic DNA protocols can be expected to become more rapid and sensitive and provide stronger investigative potential. New short tandem repeat (STR) loci have expanded the core set of genetic markers used for human identification in Europe and the USA. Rapid DNA testing is on the verge of enabling new applications. Next-generation sequencing has the potential to provide greater depth of coverage for information on STR alleles. Familial DNA searching has expanded capabilities of DNA databases in parts of the world where it is allowed. Challenges and opportunities that will impact the future of forensic DNA are explored including the need for education and training to improve interpretation of complex DNA profiles.

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“…In our model (1), the linear relationship in (2) and (3) is expressed by a multiplication with the stutter matrix S. Although this model is simple, it is widely used to describe the effects of stutter [10], [13], [16]. It has been observed that the stutter proportion is not constant within a locus.…”

Section: Stuttermentioning

confidence: 99%

“…Applying thresholds during analysis has the drawback that information is lost. For that reason, continuous methods, where fewer or no thresholds are used, have been developed [11], [13], [14]. In these methods the full variability in the peak heights is taken into consideration, which leads to a soft decision instead of a hard limiting.…”

Section: Introductionmentioning

confidence: 99%

A signal model for forensic DNA mixtures

Monich

Grgicak

Cadambe

et al. 2014

2014 48th Asilomar Conference on Signals, Systems and Computers

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Abstract-For forensic purposes, short tandem repeat allele signals are used as DNA fingerprints. The interpretation of signals measured from samples has traditionally been conducted by applying thresholding. More quantitative approaches have recently been developed, but not for the purposes of identifying an appropriate signal model. By analyzing data from 643 single person samples, we develop such a signal model. Three standard classes of two-parameter distributions, one symmetric (normal) and two right-skewed (gamma and log-normal), were investigated for their ability to adequately describe the data. Our analysis suggests that additive noise is well modeled via the log-normal distribution class and that variability in peak heights is well described by the gamma distribution class. This is a crucial step towards the development of principled techniques for mixed sample signal deconvolution.

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The interpretation of single source and mixed DNA profiles

Cited by 248 publications

References 23 publications

Probabilistic characterisation of baseline noise in STR profiles

Probabilistic characterisation of baseline noise in STR profiles

The future of forensic DNA analysis

A signal model for forensic DNA mixtures

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