The Interrelationships of Serum Cholesterol, Cholesterol Esters and Phospholipids in Health and in Coronary Artery Disease

Abstract

Serum cholesterol (free, esters and total) and serum phospholipids were determined in 97 men who had experienced coronary heart disease prior to the age of 40, 146

The Influence of Intravenously Administered Surface-Active Agents on the Development of Experimental Atherosclerosis in Rabbits

“…This possibility is further strengthened by the observation that cholesterol-fed rabbits with atherosclerosis were found consistently to have relatively low blood phospholipid levels as compared to their cholesterol levels. A similar disparity between blood phospholipid and cholesterol has been reported in chickens in which atherosclerosis had been produced by cholesterol feeding (20), and more recently, in human beings with clinical evidence of atherosclerosis (21), the findings suggesting that the decrease in blood phospholipid with respect to cholesterol, by altering the colloidal stability of the lipid emulsion, may be involved in the pathogenesis of experimental and naturally occurring atherosclerosis. It would thus seem desirable to study directly the role of phospholipids in the pathogenesis of atherosclerosis by selectively raising the blood phospholipid level in cholesterol-fed animals.…”

Studies of Male Survivors of Myocardial Infarction

“…[1][2][3][4] This is illustrated in figure 1 by the serum cholesterol concentrations of the subjects of the present study.4 Figure 1 also shows that there is a significant decrease in serum cholesterol from decade to decade in the coronary group (regression coefficient, -15.4 ± 3.9 S.E.). This together with the data of others3 suggests that the higher the serum cholesterol level the younger is the age of onset of clinical coronary heart disease.…”

Effect of Dietary Maitake (Grifola frondosa) Mushrooms on Plasma Cholesterol and Hepatic Gene Expression in Cholesterol-Fed Mice

“…TG/PL in the HC G group was significantly lower than those in the N group. It has been reported that the serum TC/PL is significantly increased in the coronary heart disease group in contrast to the normal group 16 . Our data suggest that ingestion of G. frondosa reduced this ratio.…”