The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition

Bailón, Elvira; Camuesco, Desirée; Nieto, Ana; Concha, Ángel; Arriba, Alberto Fernández de; Román, Juan; Ramis, Isabel; Zarzuelo, Antonio; Gálvez, Júlio; Comalada, Mònica

doi:10.1016/j.bcp.2007.07.026

Cited by 15 publications

(21 citation statements)

References 39 publications

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“…The intestinal anti-inflammatory effects of UR-1505 have been supported by our in vitro results demonstrating the specificity of UR-1505 towards T-cell activity, without affecting macrophage activation (2,4,5). However, in those previous studies, we only focused in the Th1- † Both authors contributed equally to the supervision of the study.…”

mentioning

confidence: 73%

“…UR-1505 was dissolved in a vehicle consisting of Tween 80 in distilled water (1%) and administered orally by an esophageal catheter. Once rats were killed, different longitudinal colonic segments were used for immunological determinations (4,5). The results reveal that the inflammatory process induced by DSS showed reduced IL-10 and IgA secretions in the colonic specimens, while an increase in IgG levels was observed (Fig.…”

mentioning

confidence: 91%

“…UR-1505 has demonstrated the in vivo antiinflammatory effect in both TNBS-and DSS-established colitis, as evidenced histologically by an improvement in the damaged colonic tissue and immunologically by the down-regulation of tumor necrosis factor alpha (TNFα) and interleukin (IL)-1β (4,5). The intestinal anti-inflammatory effects of UR-1505 have been supported by our in vitro results demonstrating the specificity of UR-1505 towards T-cell activity, without affecting macrophage activation (2,4,5).…”

mentioning

confidence: 99%

“…In the present study, we further evaluated whether the anti-inflammatory effect of UR-1505 could also be associated with an inhibition of Th2-cytokines, such as IL-5, IL-4, and IL-10, according to the previously described methodology (4,5). Stimulation of splenocytes with concanavalin A (Con A) (5 μg / ml) induced the production of these cytokines (Table 1).…”

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confidence: 99%

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The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

Bailón¹,

Román²,

Ramis³

et al. 2009

J Pharmacol Sci

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confidence: 73%

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confidence: 91%

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confidence: 99%

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confidence: 99%

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The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

Bailón¹,

Román²,

Ramis³

et al. 2009

J Pharmacol Sci

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“…Experimental animal models are commonly used to simplify and study complex human pathologies such as allergy or colitis [23,24,25,26,27,28,29,30,31,32,33], and they allow the discovery of interactions and common elements of particular signaling events and molecular pathways. With this aim, we examined the exacerbating or inhibitory potential of active intestinal colitis on the allergic response to an internalized food antigen, using the dinitrofluorobenzene/dinitrosulfonic acid (DNFB/DNS) model of colitis [27] and a well-established model of allergy based on ovalbumin (OVA) intraperitoneal (IP) sensitization and challenge.…”

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confidence: 99%

Active Colitis Exacerbates Immune Response to Internalized Food Antigens in Mice

Cueto-Sola

Bailón²,

Utrilla³

et al. 2013

Int Arch Allergy Immunol

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Background: Previous studies have indicated that colitis increases intestinal permeability to food antigens. This condition also generates an immunoreactive milieu in the gut, which may exacerbate or counteract allergy reactions. This, along with the fact that both colitis and allergy are being codiagnosed more frequently, means the scientific interest on the immune relation between these pathologies is increasing. We evaluated the immune response to an internalized food antigen that was initiated during a concomitant active intestinal inflammatory response. Methods: An ovalbumin (OVA)-induced immune response was analyzed in healthy mice and in mice suffering from colitis induced by the administration of dinitrofluorobenzene/dinitrosulfonic acid (DNFB/DNS) at the moment of OVA challenge. The OVA-induced clinical score and allergy response both in plasma and in splenocyte cultures from these animals were compared. Results: Although no differences were observed in the allergy clinical score, the concomitant active colitis led to an increase in the immune response to OVA antigen, as shown by increased spleen size and OVA-induced splenocyte proliferation, exacerbated expression of total and OVA-specific IgG1 levels, increased colonic IL-4 expression and OVA-induced IL-4 and IL-5 cytokine expression in spleen cells. Conclusions: Our results indicate that animals with active colitis undergo an exacerbated immune response to an internalized antigen. This finding could be relevant for the allergy management of patients presenting simultaneously with chronic colitis.

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UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis

Bailón

Comalada

Román³

et al. 2008

Inflammatory Bowel Diseases

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These results suggest that this compound is a good candidate for inducing remission or maintaining therapies in human inflammatory bowel disease (IBD). Moreover, the different results obtained by UR-1505 in these 2 protocols of colitis induction (acute initial colitis versus established colitis) confirm the importance of selection and optimization of the experimental model to evaluate the drugs to be used in IBD therapy.

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The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition

Cited by 15 publications

References 39 publications

The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

Active Colitis Exacerbates Immune Response to Internalized Food Antigens in Mice

UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis

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