The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls

Schultsz, Constance; Berg, F. M. Van Den; Kate, F. W. Ten; Tytgat, G. N. J.; Dankert, J.

doi:10.1016/s0016-5085(99)70393-8

Cited by 279 publications

(220 citation statements)

References 24 publications

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“…This index allows the normalization of the 257 biopsy size by quantifying human cells and includes total bacteria as an additional 258 parameter, as it has been reported that it can vary between groups of patients (Kleessen 259 et al, 2002;Schultsz et al, 1999;Swidsinski et al, 2002). 260…”

mentioning

confidence: 99%

Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes

López-Siles

Martínez-Medina

Busquets

et al. 2014

International Journal of Medical Microbiology

116

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confidence: 99%

Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes

López-Siles

Martínez-Medina

Busquets

et al. 2014

International Journal of Medical Microbiology

116

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“…Muc2 shows differential glycosylation profiles in the small intestine (ileum) and in the large intestine (colon) being enriched in either sialylated or sulfated oligosaccharide species, respectively (9,12). The mucus production and composition modulations are commonly observed in the colonic mucinous carcinoma but also in the major inflammatory bowel diseases like Crohn's disease (13,14) and ulcerative colitis (15).…”

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confidence: 99%

Design of a Specific Colonic Mucus Marker Using a Human Commensal Bacterium Cell Surface Domain

Coïc

Baleux

Poyraz

et al. 2012

Journal of Biological Chemistry

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Background: Imaging colonic mucus on living cells, tissues, and organs is required for live microscopy. Results: We have identified, synthesized, and validated a new human colonic mucus bacterial marker (MUB 70 ). Conclusion: This non-toxic marker is used to image the secreted colonic mucus. Significance: Beyond imaging applications, Cy5-MUB 70 might be used for diagnostic and prognosis applications on colonic mucinous carcinoma.

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“…A lthough the precise etiology of Crohn disease (CD; Online Mendelian Inheritance in Man 266600) is unknown, biochemical and clinical observations (1) suggest a breakdown of tolerance to luminal bacteria (2)(3)(4)(5) in the digestive tract of susceptible individuals. CARD15, formerly called NOD2, has recently been identified as a CD-susceptibility gene (6,7).…”

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confidence: 99%

Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases

Chamaillard

Philpott

Girardin

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

285

218

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CARD15 is a major susceptibility gene for a frequent multifactorial chronic inflammatory bowel disorder, Crohn disease (CD). By using NF-B activation assays, the cytosolic CARD15 was shown to efficiently detect bacterial peptidoglycan (PGN), reminiscent of the PGN recognition protein surveillance mechanism in Drosophila. The 3 CD-associated variants and 13 additional variants carried by CD patients demonstrated impaired PGN-dependent response revealing null, hypomorphic, or dominant-negative properties. Quantitative parametrization of this response, computed from the patients' CARD15 genotypes, was predictive of several variable CD manifestations. In contrast, CARD15 alleles associated with Blau's syndrome promoted PGN-independent NF-B activation, an observation that accounts for the minimal microbial input in the etiology of this dominant, monogenic inflammatory disorder affecting solely aseptic sites.

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The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls

Cited by 279 publications

References 24 publications

Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes

Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes

Design of a Specific Colonic Mucus Marker Using a Human Commensal Bacterium Cell Surface Domain

Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases

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