The intracellular life of<i>Chlamydia psittaci</i>: how do the bacteria interact with the host cell?

Escalante-Ochoa, Cristina; Ducatelle, Richard; Haesebrouck, Freddy

doi:10.1111/j.1574-6976.1998.tb00361.x

Cited by 18 publications

(8 citation statements)

References 101 publications

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“…Moulder [15] has defined intracellular parasitism as the solution to a set of common problems: “(i) how to get inside the host cell; (ii) how, once inside, to avoid being killed; (iii) how to multiply intracellularly; (iv) how to maintain host functions essential for parasite multiplication; (v) how to get new generations of parasites out of the host cell in which they were made; and, (vi) how to get from old host cells to new ones”. Several previous reviews about intracellular parasites have discussed processes such as attachment, internalization, virulence, avoidance of degradation and transmission [5,6,14–16]. The purpose of this review is to discuss general strategies for growth in the intracellular habitat as inferred from a comparative analysis of the 1.1 and 1.0 Mb genomes of R. prowazekii and C. trachomatis .…”

Section: Introductionmentioning

confidence: 99%

Obligate intracellular parasites: Rickettsia prowazekii and Chlamydia trachomatis

Zomorodipour

Andersson

1999

FEBS Letters

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Transitions to obligate intracellular parasitism have occurred at numerous times in the evolutionary past. The genome sequences of two obligate intracellular parasites, Rickettsia prowazekii and Chlamydia trachomatis, were published last year. A comparative analysis of these two genomes has revealed examples of reductive convergent evolution, such as a massive loss of genes involved in biosynthetic functions. In addition, both genomes were found to encode transport systems for ATP and ADP, not otherwise found in bacteria. Here, we discuss adaptations to intracellular habitats by comparing the information obtained from the recently published genome sequences of R. prowazekii and C. trachomatis.z 1999 Federation of European Biochemical Societies.

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Section: Introductionmentioning

confidence: 99%

Obligate intracellular parasites: Rickettsia prowazekii and Chlamydia trachomatis

Zomorodipour

Andersson

1999

FEBS Letters

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“…A psitacose é uma zoonose causada sobretudo pela bactéria Chlamydia psittaci, um microrganismo gramnegativo, intracelular obrigatório (11), que infecta principalmente aves, mas que pode ser transmitida ao ser humano através da inalação de aerossóis e poeiras, contaminados com origem na urina, fezes ou outras secreções dos animais (12).…”

Section: Conteúdo Etiologia E Fisiopatologiaunclassified

“…Uma vez internalizados, o corpo elementar converte-se no corpo reticular. Estes originam projeções na membrana da bactéria que facilitam a obtenção de nutrientes (11).…”

Section: Conteúdo Etiologia E Fisiopatologiaunclassified

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Psitacose e Saúde Ocupacional

Pereira¹,

Vieira²,

Pintó³

et al. 2022

RPSO

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Introduction/framework/objectives Psittacosis is a rare entity caused by Chlamydophila psittaci. This bacterium is transmitted through contact with contaminated birds, namely psittaciformes, which include parrots, macaws and parakeets, as pigeons and chickens. The objective of this work is to highlight the pathology and the role of Occupational Health in it. Methodology A bibliographic search was carried out on original articles published in Portuguese and English, in June 2022, in the PubMed and Cochrane Library databases, using the keywords “Psittacosis”, “Occupational exposure” and “Occupational health”. Three articles were also included, not covered by the research, relevant to the work, for reporting the Portuguese reality. Contents Outbreaks can occur in workers with occupations that involve contact with live birds or carcasses, such as veterinarians, breeders, or pet store workers. However, it is difficult to establish the precise incidence and prevalence of psittacosis, probably due to the lack of routine screening. Transmission occurs mainly by aerosols, inhalation of urine, feces or other contaminated particles; transmission between humans, although possible, is rare. The incubation period ranges from five to 14 days, but may extend to weeks in cases of subacute or latent infection. It has a clinical presentation like a flu-like syndrome and can cause disseminated and even potentially fatal disease. The most frequent findings on chest radiography are segmental or lobar consolidation, especially in the lower lobes. It can occasionally cause marked leukocytosis, c-reactive protein (CRP) is often elevated, and liver enzymes change in approximately half of hospitalized patients, with elevation of aspartate aminotransferase (AST) and low serum albumin levels. Tetracyclines are the drug of choice for treatment. Discussion and Conclusions Although the number of cases is apparently small, the impact of the disease is most likely underestimated. Thus, it is necessary to increase the awareness of this pathology both for Occupational Health professionals and for employers and workers themselves. On the other hand, an approach is needed that encompasses collaboration between human and animal health agencies, laboratories and medical and veterinary professionals, for timely surveillance, reporting and treatment. Thus, anamnesis and early recognition of the epidemiological context are extremely important, with a view to diagnosing and instituting appropriate therapy. In addition, occupational risk factors and exposure control among workers should be considered to prevent transmission in the workplace. KEYWORDS: psittacosis, occupational exposure, occupational health.

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“…Chlamydia psittaci is an intracellular pathogen (1). It is a zoonotic pathogen that infects a wide range of birds as hosts and may cause severe disease when is transmitted to humans (2).…”

Section: Introductionmentioning

confidence: 99%

Difficulties in Diagnosis of Psittacosis or Ornithosis: A Case Report

Ebrahimi

Fadii

Mardani

et al. 2019

Arch Clin Infect Dis

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Introduction:Chlamydia psittaci is an intracellular and zoonotic pathogen that is transmitted through contact with birds. This pathogen causes various clinical manifestations, including subclinical cases and fatal cases. On the other hand, the variety and low specificity of many of the symptoms make diagnosis difficult while early detection of the disease causes a significant reduction in mortality. Case Presentation: The patient was a 47-year-old man with a history of headache, fever, chills, dyspnea, and productive cough with a primary diagnosis of sinusitis, which was treated with co-amoxiclav. Due to the lack of recovery, the patient was hospitalized with the diagnosis of pneumonia and was treated with meropenem and levofloxacin. After showing no improvement and finding out about the history of contact with a parrot, the treatment was changed to Doxycycline and Ceftriaxone, which led to the reduction of symptoms. Eventually, due to the patient's positive serological tests, the diagnosis of Chlamydia Pneumonia was established and the patient was discharged with oral doxycycline. Conclusions: As the fatality rate of psittacosis in absence of treatment is high, it is necessary to treat the patient immediately.

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The intracellular life ofChlamydia psittaci: how do the bacteria interact with the host cell?

Cited by 18 publications

References 101 publications

Obligate intracellular parasites: Rickettsia prowazekii and Chlamydia trachomatis

Obligate intracellular parasites: Rickettsia prowazekii and Chlamydia trachomatis

Psitacose e Saúde Ocupacional

Difficulties in Diagnosis of Psittacosis or Ornithosis: A Case Report

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