The Intriguing Relationship of &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection and Acid Secretion in Peptic Ulcer Disease and Gastric Cancer

Malfertheiner, Peter

doi:10.1159/000332213

Cited by 80 publications

(54 citation statements)

References 68 publications

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“…Este fenó-meno pudiese vincularse con lo reportado por Tsukui et al 24 , quienes sugirieron que, en pacientes con dispepsia, la presencia de úlcera duodenal disminuye el riesgo de desarrollar gastritis atrófica y metaplasia intestinal en el cuerpo gás-trico. La presencia de úlcera duodenal se asocia a pocos cambios atróficos, gastritis predominantemente antral y bajo riesgo de desarrollar cáncer gástrico 25 .…”

Section: Discussionunclassified

“…Se ha reportado que las poblaciones localizadas a nivel del mar consumen mayores cantidades de pescado, vegetales y frutas frescas, y presentan mayores tasas de parasitosis intestinal por helmintos 6,36 . Esta última circunstancia genera una respuesta inmunitaria predominantemente tipo Th2, que se vincula con la evasión de la gastritis atrófica y menor efecto antisecretor de algunas citocinas proinflamatorias 6,25,36 .…”

Section: Discussionunclassified

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Estimación de riesgo de cáncer gástrico en pacientes con gastritis crónica asociada a la infección por Helicobacter pylori en un escenario clínico

Arismendi-Morillo¹,

Hernández²,

Mengual³

et al. 2013

Revista de Gastroenterología de México

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Section: Discussionunclassified

Estimación de riesgo de cáncer gástrico en pacientes con gastritis crónica asociada a la infección por Helicobacter pylori en un escenario clínico

Arismendi-Morillo¹,

Hernández²,

Mengual³

et al. 2013

Revista de Gastroenterología de México

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“…21,22 Firstly, the infection of the stomach by H. pylori induces inflammation of the gastric mucosa (gastritis) and is estimated that occur in the most patients infected by H. pylori. 23 H. pylori infection may be associated with decreased or increased gastric acid secretion, depending on the distribuition and severity of gastritis. 4 The interplay of gastritis and acid secretion are key determinants in disease outcomes such as peptic ulcer and/or gastric cancer.…”

Section: Helicobacter Pylori Infection: From Gastric Inflammation Tomentioning

confidence: 99%

“…4 The interplay of gastritis and acid secretion are key determinants in disease outcomes such as peptic ulcer and/or gastric cancer. 23 Ulceration corresponds to the loss of mucosal integrity as the result of disequilibrium between defensive mucosa-protective factors (mucus bicarbonate layer and phospholipid surfactant layer) and aggressive injurious factors (strong acid and high proteolytic activity in gastric secretions). When ulcers develop in the acid-peptic environment of the gastroduodenum, they are called peptic ulcer disease.…”

Section: Helicobacter Pylori Infection: From Gastric Inflammation Tomentioning

confidence: 99%

Genes de patogenicidade de Helicobacter pylori, polimorfismos de citocinas e fatores ambientais afetam o desenvolvimento de doenças gástricas: uma visão geral

Vianna¹,

Silva²,

Ramis³

2016

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. pylori possui um conjunto de fatores de patogenicidade, tais como cagA, vacA, iceA, babA, para colonizar a mucosa gástrica e estabelecer infecção crônica. Estes fatores bacterianos são agentes essenciais em modular a resposta imune envolvida na iniciação da carcinogênesegástrica. Os fatores genéticos do hospedeiro contribuem para regular a resposta inflamatória e para o agravamento da lesão da mucosa gástrica uma vez que a infecção gástrica por H. pylori induz a produção de várias citocinas pró e anti-inflamatórias no hospedeiro. O papel prejudicial dos fatores ambientais está relacionado com as precárias condições socioeconômicas, com o consumo de sal, com o tabagismo e com o consumo de álcool. Conclusão: Ao decifrar as regras deterministas -se houver -dessa interação entre fatores da bactéria, do hospedeiro e variáveis ambientais, será possível prever, tratar e, finalmente, prevenir graves doenças gastroduodenais. Background and Objectives:Helicobacter pylori is a Gram-negative bacterium that colonizes the stomach of approximately 50% of the world´s human population. This microorganismis the major causal agent of gastritis and is an important risk factor for the development of peptic ulcer disease and gastric carcinoma. The factors that determine these diverse clinical outcomes are subject to continuous investigations and is thought to be determined by interaction of bacterial factors, host immune system and environmental variables. The aim of this review is to provide an overview of these factors that influence susceptibility to severe outcomes of H. pylori

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“…(39) This could be explained by the relation between the location of gastritis and the amount of acid secretion; corpus-predominant gastritis is accompanied by hypochlorhydria and results in the highest risk for GC, whereas antrum-predominant gastritis is associated with hyperchlorhydria and predisposes to DU disease. (40,41) As PSCA is not expressed in the duodenum, its function in the stomach might affect DU development, possibly through such effects as those related to acid secretion, location and extent of HP infection or gastritis. It was also reported that the T allele was especially associated with noncardia GC in Chinese and Caucasian patients but with cardia GC in Korean patients.…”

Section: à6mentioning

confidence: 99%

Genetic factors related to gastric cancer susceptibility identified using a genome‐wide association study

et al. 2012

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Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia, where Japan and Korea have the highest incidence in the world. Gastric cancer is classified into intestinal and diffuse types. While the former is almost absolutely caused by Helicobacter pylori infection as the initial insult, the latter seems to include cases in which the role of infection is limited, if any, and a contribution of genetic factors is anticipated. Previously, we performed a genome-wide association study (GWAS) on diffusetype GC by using single nucleotide polymorphisms (SNP) catalogued for Japanese population (JSNP), and identified a prostate stem cell antigen (PSCA) gene encoding a glycosylphosphatidylinositol-anchored cell surface antigen as a GC susceptibility gene. From the second candidate locus identified using the GWAS, 1q22, we found the Mucin 1 (MUC1) gene encoding a cell membranebound mucin protein as another gene related to diffuse-type GC. A two-allele analysis based on risk genotypes of the two genes revealed approximately 95% of Japanese population have at least one of the two risk genotypes, and approximately 56% of the population have both risk genotypes. The two-SNP genotype might offer ample room to further stratify a high GC risk subpopulation in Japan and Asia by adding another genetic and/or non-genetic factor. Recently, a GWAS on the Chinese population disclosed an additional three GC susceptibility loci: 3q13.31, 5p13.1 and 10q23. (Cancer Sci 2013; 104: 1-8) G astric cancer (GC) is one of the major malignant diseases and the second causal of cancer death worldwide.(1) It is usually classified into two types, intestinal and diffuse, a classification which was originally based on histological observation but is recently thought to reflect its pathogenesis.(2) The majority of intestinal-type GC (IGC) arises in the sequence of inflammatory change of the gastric epithelium resulting from bacterial infection; Helicobacter pylori (HP) infectionchronic inflammation -intestinal metaplasia -dysplasia -adenocarcinoma. In contrast, de novo diffuse-type GC (DGC) is thought to emerge in a histologically almost normal epithelium as a consequence of some genetic change that occurred in gastric stem cells and/or epithelial precursor cells, although some cases with DGC might represent dedifferentiated stages of IGC, and a contribution of HP is also suggested.(3) In other words, it is apparent that the pathogenesis of IGC is initiated by HP infection, a class I carcinogen acknowledged by WHO, and therefore IGC is essentially a preventable disease by eradicating HP infection. However, DGC might develop earlier in life than IGC, (4) and no definite DGC-specific environmental risk factor has been established. Therefore, so far we have neither solid strategy nor promising theory to envision a consistent diminution of the incidence of DGC.The incidence of GC has strong geographical and ethnical characteristics. For example, it is one of the rare cancers in North America and Europe, while its incidence is s...

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The Intriguing Relationship of <i>Helicobacter pylori</i> Infection and Acid Secretion in Peptic Ulcer Disease and Gastric Cancer

Cited by 80 publications

References 68 publications

Estimación de riesgo de cáncer gástrico en pacientes con gastritis crónica asociada a la infección por Helicobacter pylori en un escenario clínico

Estimación de riesgo de cáncer gástrico en pacientes con gastritis crónica asociada a la infección por Helicobacter pylori en un escenario clínico

Genes de patogenicidade de Helicobacter pylori, polimorfismos de citocinas e fatores ambientais afetam o desenvolvimento de doenças gástricas: uma visão geral

Genetic factors related to gastric cancer susceptibility identified using a genome‐wide association study

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