Estimación de riesgo de cáncer gástrico en pacientes con gastritis crónica asociada a la infección por Helicobacter pylori en un escenario clínico

Arismendi-Morillo, Gabriel; Hernández, Israel Alejandro Quijano; Mengual, Edgardo; Abreu, Nuno; Molero, Nelly Petit de; Fuenmayor, A.; Romero, Gisela; Lizarzábal, Maribel

doi:10.1016/j.rgmx.2013.01.004

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…El H pylori desempeña un rol importante en la progresión de la enfermedad por su interacción con el huésped, asociado con el desarrollo de cambios inflamatorios crónicos, atrofia de la mucosa y disbiosis; también es catalogado como carcinógeno tipo 1 (3,19). Esta infección se adquiere usualmente durante la infancia y persiste de forma crónica, si la bacteria no es erradicada (20). Dentro de este marco, se ha observado una serie de eventos consecutivos partiendo desde un estómago normal hasta una gastritis atrófica, relacionados con la presencia del H pylori y la edad (envejecimiento) de los sujetos (21) Este estudio revela, además que los agentes exógenos como AINEs, alimentación inadecuada, consumo de alcohol y tabaquismo, se presentaron en el 63 % de los pacientes, coincidiendo con lo reportado por Duquense (12) donde los agentes exógenos estaban en más de un tercio de la población estudiada.…”

Section: Discussionunclassified

“…Así mismo, se ha señalado la existencia de una fuerte asociación entre la gastritis atrófica y metaplasia intestinal tipo 1, que prosigue hacia la displasia para culminar con el desarrollo del adenocarcinoma gástrico, situación que depende de la intensidad y persistencia de las mismas (25), tal es el caso que la lesión atrófica del tipo pangastritis y las de ubicación corporal aumentan aún más el riesgo de cáncer gástrico e intestinal (20).…”

Section: Lasunclassified

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Plan De Marketing Para La Difusión De La Marca Isaac Molina Coaching Comercial, en El Sector Norte De La Ciudad De Guayaquil

Guerra¹,

Hernández²,

Castellanos³

2021

prohominum

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Introducción: La gastritis es una enfermedad con una alta morbilidad a nivel mundial, el principal actor de riesgo es la infección por Helicobacter pylori. Objetivo: Describir las características clínicas, histopatológica y endoscópicas en una población con gastritis crónica. Material y métodos: Se realizó un estudio observacional de tipo descriptivo, retrospectivo, se incluyeron 49 pacientes que acudieron a la consulta externa del área de gastroenterología, de 18 a 65 años, a quienes se realizó el estudio histopatológico y endoscópico en el Servicio de Gastroenterología en el Hospital General Quevedo, de Los Ríos-Ecuador, durante septiembre 2017 – septiembre 2018. Resultados: Se observó predominio del género masculino (65%); en mayores de 40 años (55%), la epigastralgía y la sensación de acidez estomacal, 39% y 35% respectivamente, fueron los síntomas más frecuentes, La positividad para Helicobacter pylori, alcanzó el 86%, y la lesión no erosiva un 73%, existió mayor presencia de la forma no atrófica (84%) sobre la atrófica. Conclusiones: La gastritis crónica predominó en el grupo etario mayor a 40 años y de género masculino, siendo los factores de riesgo de mayor prevalencia la infección por Helicobacter pylori y los asociados al consumo de antiinflamatorios no esteroideos, mala alimentación, alcohol y tabaco, los síntomas como epigastralgía y la sensación de acidez estomacal fueron los más frecuentes. El hallazgo endoscópico fue mayor para las formas no erosivas, y de acuerdo a la histopatología la gastritis no atrófica antral moderada fue la más frecuente.

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Plan De Marketing Para La Difusión De La Marca Isaac Molina Coaching Comercial, en El Sector Norte De La Ciudad De Guayaquil

Guerra¹,

Hernández²,

Castellanos³

2021

prohominum

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“…It has been shown that HPI could induce gastric cancer through multiple pathogenic steps [12][13][14] . Chronic gastritis have been demonstrated to be the main cause of gastric MALT lymphoma in HPI patients, and MALT lymphoma induced tumor regression in 70 % to 80 % of patients [15][16][17] .…”

Section: Digestive Diseasesmentioning

confidence: 99%

Helicobacter Pylori Infection Associated Diseases – A Systematic Review

2017

Med One

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Helicobacter pylori (H. pylori) infection (HPI) is one of the most widespread diseases. More than half of world population is affected by HPI, especially children in developing countries. The associations between many gastrointestinal diseases and HPI have been found in clinical. Also, there are some diseases whose HPI associations are controversial and unclear. Due to its unclear disease association, H. pylori test is not included in the clinical screening. However, some pre-clinical studies showed possible associations between HPI and these diseases, involving pathological changes of different functional systems of the human body (e.g., Immune system, cerebrovascular system). Therefore, for HPI patients, more attention should be paid to the possible risks of these diseases. In this study, a systematic literature review was conducted to identify and classify H. pylori related diseases. This review identified 175 HPI related diseases belonging to 9 categories, and summarized the corresponding supporting literature reports. In addition, the functional mechanisms underlying the linkages between HPI and 28 well studied diseases were discussed, revealing possible pathogenesis for these diseases. We conclude that HPI is related to many serious diseases affecting multiple important human systems, and clinical HPI treatment and HPI test might help the detection and treatment of these diseases. Our results guarantee further study using more data to testify the possible relations between HPI and these diseases.

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“…But these drugs safety was proved in patients with intact SM [7,14]. At the same time at CG a number of inflammatory and degenerative processes in the gastric epithelium develops [19], which, possibly may cause the increased risk of erosive gastropathy at NSAID-therapy.…”

Section: Introductionmentioning

confidence: 99%

Chronic Gastritis Clinical Features and Stomach Functional State During Nonsteroidal Anti-Inflammatory Drugs Administration in Patients With Osteoarthritis

Zaк

Pasiyeshvili

2016

EUREKA: Health Sciences

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Aim. Determination of chronic gastritis clinical features and stomach functional state during nonsteroidal anti-inflammatory drugs (NSAID) administration in patients with osteoarthritis (OA). Materials and methods. 122 patients with OA and verified chronic gastritis (CG) (50 males and 72 females) aged 42 to 64 years (mean age – 49.65±3.51) were observed. Depending on gastritis morphological form, patients were divided into 2 groups: 54 patients with OA in combination with non-atrophic gastritis (NAG) were included into the group I, 68 patients with OA in combination with atrophic gastritis (AG) – into group II. 40 patients with OA without concomitant gastroduodenal pathology in anamnesis were included into the group III. All patients obtained selective NSAID for OA treatment: Meloxicam 15 mg daily or Nimesulide 200 mg daily. The control group was formed by 20 persons, which were found to be healthy after a complex examination. Stomach acid-forming function was investigated using esophageal pH monitoring. In the gastric contents, which obtained by aspiration, concentration of sialic acids glycoproteins, fucose, and hexosamines was determined. Results. Clinical picture of NSAID gastropathy at NAG characterized by abdominal pain of varying intensity and not associated with eating, but in patients with AG severity and discomfort symptoms dominated over weakly expressed pain syndrome. As a result of NSAID, in the group I dyspepsia developed in 31 (57.4 %), and erosive gastropathy developed in 9 (16.7 %) patients. In the group II, erosive gastropathy and dyspepsia were observed in 15 (22.1%) and in 35 (51.5 %) patients, respectively. In the group III, erosive gastropathy was observed 3.3 times (c2=84.33; р=0.009) and 4.4 times (c2=36.78; р=0.002) less than in groups I and II, respectively. In 25% patients of the group I after NSAID therapy intragastric pH increased from normacid to hyperacid status. In the group II, NSAID administration led to stomach mucosal (SM) protective factors depletion, which was observed in 73.3 % and in 28.6 % of patients with erosive gastropathy and NSAID-associated dyspepsia, respectively. At AG with erosive gastropathy, unlike NAG, several protective factors simultaneous reduction was observed. Coonclusion. In anamnesis, CG factor at selective NSAID administration (Meloxicam and Nimesulide) in relation to OA significantly increases the risk of erosive gastropathy, compared with patients without CG in anamnesis. At OA NSAID administration in patients with NAG led to gastric contents acidification and in patients with AG – to SM protective factors depletion (glycoprotein, fucose, and hexosamine).

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Estimación de riesgo de cáncer gástrico en pacientes con gastritis crónica asociada a la infección por Helicobacter pylori en un escenario clínico

Abstract: The estimated gastric cancer risk in patients with CGAHpI in the clinical setting studied was relatively low and 5% of the patients had a histopathologic phenotype associated with an elevated risk for developing gastric cancer.

Cited by 6 publications

References 27 publications

Plan De Marketing Para La Difusión De La Marca Isaac Molina Coaching Comercial, en El Sector Norte De La Ciudad De Guayaquil

Plan De Marketing Para La Difusión De La Marca Isaac Molina Coaching Comercial, en El Sector Norte De La Ciudad De Guayaquil

Helicobacter Pylori Infection Associated Diseases – A Systematic Review

Chronic Gastritis Clinical Features and Stomach Functional State During Nonsteroidal Anti-Inflammatory Drugs Administration in Patients With Osteoarthritis

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