The introduction of successful treatment of diabetes mellitus with                insulin

Stylianou, Charilaos; Kelnar, Christopher J. H.

doi:10.1258/jrsm.2009.09k035

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…A century ago, young people with diabetes could expect to live for a year or two following diagnosis. 37 The development of insulin at the University of Toronto in 1922 was a milestone, transforming DKA from a death sentence to a treatable illness. Today, despite this progress, far too many suffer from DKA.…”

Section: Discussionmentioning

confidence: 99%

The Incidence of Diabetic Ketoacidosis During “Emerging Adulthood” in the USA and Canada: a Population-Based Study

et al. 2019

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BACKGROUND: As children with diabetes transition to adulthood, they may be especially vulnerable to diabetic ketoacidosis (DKA). Cross-national comparisons may inform efforts to avoid this complication. OBJECTIVE: To compare DKA hospitalization rates in the USA and Manitoba, Canada, during the vulnerable years known as "emerging adulthood." DESIGN: Cross-sectional study using inpatient administrative databases in the USA (years 1998-2014) and Manitoba, Canada (years 2003-2013). PARTICIPANTS: Individuals aged 12-30 years hospitalized with DKA, identified using ICD-9 (USA) or ICD-10 codes (Manitoba). MAIN MEASURES: DKA hospitalization rates per 10,000 population by age (with a focus on those aged 15-17 vs. 19-21). Admissions were characterized by gender, socioeconomic status, year of hospitalization, and mortality during hospitalization. KEY RESULTS: The DKA rate was slightly higher in the USA among those aged 15-17: 4.8 hospitalizations/ 10,000 population vs. 3.7/10,000 in Manitoba. Among those aged 19-21, the DKA hospitalization rate rose 90% in the USA to 9.2/10,000, vs. 23% in Manitoba, to 4.5/ 10,000. In both the USA and Manitoba, rates were higher among those from poorer areas, and among adolescent girls compared with adolescent boys. DKA admissions rose gradually during the period under study in the USA, but not in Manitoba. CONCLUSIONS: In years of "emerging adulthood," the Canadian healthcare system appears to perform better than that of the USA in preventing hospitalizations for DKA. Although many factors likely contribute to this difference, universal and seamless coverage over the lifespan in Canada may contribute.

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Section: Discussionmentioning

confidence: 99%

The Incidence of Diabetic Ketoacidosis During “Emerging Adulthood” in the USA and Canada: a Population-Based Study

et al. 2019

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“…The first injection of a crude beef pancreatic extract was given to 14-year-old Leonard Thompson on January 11, 1922. The discovery of insulin was awarded the Nobel Prize in Medicine in 1923 (5).…”

Section: Diabetes Mellitus -Epidemiologymentioning

confidence: 99%

Continuous glucose monitoring: review of promising technologies

Klimek

Tulwin

2019

MATEC Web Conf.

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Despite the progress we have made in the management of diabetes it is still incurable and aggravating disease affecting all domains of quality of life. Uncontrolled diabetes associated with hyperglycemia leads to serious microvascular and macrovascular long-term complications. The proper longterm glycemic control is a key strategy for preventing the development or slowing the progression of diabetes complications, thus there is a crucial role of new technologies in the diabetes care. New technologies in diabetology are developing dynamically in recent years and therefore this is a topical issue. In this paper we describe current and developing continuous glucose monitoring technologies and their usefulness in promoting optimal glycemic control, influence on personalized diabetes managements and the functioning of patients. Moreover we review knowledge about flash glucose monitoring and close-loop system. This review examines studies published before 31st August 2018.

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“…The boy died at the age of 27, but the cause of his death was not diabetes and its complications, but pneumonia. Researchers continued testing the extract and in February 1922 qualified six people for treatment, but in these cases, the treatment was successful [13][14][15][16][17][18][19]. For the first time, the researchers announced the results of their work in May 1922 during the meeting of the Association of American Physicians.…”

Section: The Islets Of Langerhans or How Did It Begin?mentioning

confidence: 99%

From islets of Langerhans to insulin analogs. It’s been almost 100 years since the discovery of insulin

Cieluch

Magowska

Zozulińska‐Ziółkiewicz

2019

Clinical Diabetology

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Until the discovery of insulin, diabetes was a fatal disease. The diet was the only form of treatment for this disease. Since the discovery of the Langerhans Islands, huge progress has been made in the treatment of diabetes. In 1921 due to Banting's research and collaborators, there has been a revolution in the treatment of diabetes. A disease that was once incurable could be controlled by insulin injections. Today insulin is not only a life-saving medicine. After the breakthrough discovery of scientists, research was conducted to improve insulin. Ultimately, these actions led to the creation of insulin analogs to make diabetes therapy even more perfect, by reducing the incidence of hypoglycemia.

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The introduction of successful treatment of diabetes mellitus with insulin

Cited by 13 publications

References 16 publications

The Incidence of Diabetic Ketoacidosis During “Emerging Adulthood” in the USA and Canada: a Population-Based Study

The Incidence of Diabetic Ketoacidosis During “Emerging Adulthood” in the USA and Canada: a Population-Based Study

Continuous glucose monitoring: review of promising technologies

From islets of Langerhans to insulin analogs. It’s been almost 100 years since the discovery of insulin

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